Time of transforming growth factor beta 1 inoculation alters the incubation of BSE in mice.

Abstract:

:Groups of 20 C57BL/6J mice (10 males and 10 females) were given BSE strain 301C i.p. and subsequently given 2 microg recombinant human TGFbeta1 s.c. at single or multiple times. There was a significant positive correlation between the day of TGFbeta1 administration and incubation time; the later TGFbeta1 was administered after BSE inoculation the longer the incubation time became. The administration of TGFbeta1 at any time point did not significantly alter the distribution or severity of pathology. The effects of TGFbeta1 on BSE pathogenesis appears to be dependent upon its time of administration; early administration shortens the incubation time and late administration lengthens the incubation time.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Kempster S,Collins ME,Edington N

doi

10.1097/00001756-200410050-00018

subject

Has Abstract

pub_date

2004-10-05 00:00:00

pages

2233-6

issue

14

eissn

0959-4965

issn

1473-558X

pii

00001756-200410050-00018

journal_volume

15

pub_type

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