Abstract:
:Groups of 20 C57BL/6J mice (10 males and 10 females) were given BSE strain 301C i.p. and subsequently given 2 microg recombinant human TGFbeta1 s.c. at single or multiple times. There was a significant positive correlation between the day of TGFbeta1 administration and incubation time; the later TGFbeta1 was administered after BSE inoculation the longer the incubation time became. The administration of TGFbeta1 at any time point did not significantly alter the distribution or severity of pathology. The effects of TGFbeta1 on BSE pathogenesis appears to be dependent upon its time of administration; early administration shortens the incubation time and late administration lengthens the incubation time.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Kempster S,Collins ME,Edington Ndoi
10.1097/00001756-200410050-00018subject
Has Abstractpub_date
2004-10-05 00:00:00pages
2233-6issue
14eissn
0959-4965issn
1473-558Xpii
00001756-200410050-00018journal_volume
15pub_type
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