Estrogen effects on arcuate neurons in rat. An in situ electrophysiological study.

Abstract:

:In acute experiments, the effects of i.p. 17beta-estradiol on the activity of arcuate neurons were studied in ovariectomized rats. 17Beta-estradiol (100 microg/100g, i.p.) increased the spontaneous activity of the observed arcuate neurons with a latency of 20-25 min. In some neurons spontaneous activity could be influenced by stimulation of the olfactory and somatosensory systems. Activation of the trigeminal system significantly increased the spontaneous activity of the studied units, while stimulation of the accessory olfactory bulb decreased it, both with and without 17beta-estradiol treatment. It is suggested that the 20-25 min latency of the 17beta-estradiol effect is based not so much on membrane as on genomic mechanisms. This suggestion is supported by immunocytochemical studies: 17beta-estradiol treatment significantly decreased the number of GABA-positive axo-somatic synapses in the arcuate nucleus.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Kis Z,Horváth S,Hoyk Z,Toldi J,Párducz A

doi

10.1097/00001756-199911260-00034

subject

Has Abstract

pub_date

1999-11-26 00:00:00

pages

3649-52

issue

17

eissn

0959-4965

issn

1473-558X

journal_volume

10

pub_type

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