Abstract:
:In acute experiments, the effects of i.p. 17beta-estradiol on the activity of arcuate neurons were studied in ovariectomized rats. 17Beta-estradiol (100 microg/100g, i.p.) increased the spontaneous activity of the observed arcuate neurons with a latency of 20-25 min. In some neurons spontaneous activity could be influenced by stimulation of the olfactory and somatosensory systems. Activation of the trigeminal system significantly increased the spontaneous activity of the studied units, while stimulation of the accessory olfactory bulb decreased it, both with and without 17beta-estradiol treatment. It is suggested that the 20-25 min latency of the 17beta-estradiol effect is based not so much on membrane as on genomic mechanisms. This suggestion is supported by immunocytochemical studies: 17beta-estradiol treatment significantly decreased the number of GABA-positive axo-somatic synapses in the arcuate nucleus.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Kis Z,Horváth S,Hoyk Z,Toldi J,Párducz Adoi
10.1097/00001756-199911260-00034subject
Has Abstractpub_date
1999-11-26 00:00:00pages
3649-52issue
17eissn
0959-4965issn
1473-558Xjournal_volume
10pub_type
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