Abstract:
:To test the possible role of ATP in transducing or modulating touch sensation, an isolated skin-nerve preparation from the toad, Bufo marinus, perfused on the inner side, was used to examine the effects of ATP on slowly adapting (SA) and rapidly adapting (RA) mechanoreceptors, identified by ramp and hold indentation of the skin. ATP (1-50 mM) did not generate impulse activity in either SA or RA mechanoreceptors nor increase their responses to mechanical stimulation. Instead, ATP (> or =5 mM) reversibly and selectively suppressed impulse discharge from SA mechanoreceptors. Our results indicate that while ATP may modulate the responses of specific touch receptors, it is not involved in transducing touch into nerve impulses.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Fallon JB,Maroto R,Hamill OP,Proske Udoi
10.1097/00001756-200208070-00019subject
Has Abstractpub_date
2002-08-07 00:00:00pages
1443-6issue
11eissn
0959-4965issn
1473-558Xjournal_volume
13pub_type
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