Abstract:
:The relationship between cerebral ischemia and Alzheimer's disease has been evaluated extensively. However, the association between cerebral ischemia and the deposition of beta-amyloid (Abeta) remains to be clarified. Here, we used mice bilateral common carotid artery ligation model to investigate the alterations in mRNA expression of Abeta precursor protein cleavage enzyme 1(BACE1), cathepsin B, and glutaminyl cyclase after transient global cerebral ischemia. The reverse-transcriptase PCR assay showed that the expressions of these three Abeta-metabolism-related genes were upregulated in brain with different manner. It indicates that all these three Abeta-metabolism-related genes may participate in the acute and chronic Abeta generation after transient cerebral ischemia, and will be helpful to understand the mechanisms underlying the linkage of brain ischemia and Alzheimer's disease.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Ye JT,Pi RB,Mao XX,Chen XH,Qin J,Xu SW,Liu PQdoi
10.1097/WNR.0b013e328332024asubject
Has Abstractpub_date
2009-10-28 00:00:00pages
1456-60issue
16eissn
0959-4965issn
1473-558Xjournal_volume
20pub_type
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