Lipid peroxidation inhibition in spinal cord injury: cyclosporin-A vs methylprednisolone.

Abstract:

:To compare the effectiveness of cyclosporin-A (CsA) with methylprednisolone (MP) or a combination of both upon inhibition of lipid peroxidation (LP) after spinal cord (SC) injury, rats were treated with either CsA, MP, CSA+MP or vehicle starting 1 h after SC contusion at T9 level. LP was assessed 24h after injury by the lipid fluorescent product formation method. The survival rate was also evaluated in other series of rats by the Kaplan-Meier curves. Lipid peroxidation was similarly inhibited in rats treated with CsA, MP, or CSA+MP (p>0.05). Animals receiving MP (alone or combined with CsA) showed the poorest surviving rate. LP was inhibited by CsA to the same extent as by MP but without the lethal effect of the latter.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Diaz-Ruiz A,Rios C,Duarte I,Correa D,Guizar-Sahagun G,Grijalva I,Madrazo I,Ibarra A

doi

10.1097/00001756-200006050-00033

subject

Has Abstract

pub_date

2000-06-05 00:00:00

pages

1765-7

issue

8

eissn

0959-4965

issn

1473-558X

journal_volume

11

pub_type

杂志文章
  • Reading skill and structural brain development.

    abstract::Reading is a learned skill that is likely influenced by both brain maturation and experience. Functional imaging studies have identified brain regions important for skilled reading, but the structural brain changes that co-occur with reading acquisition remain largely unknown. We investigated maturational volume chang...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000000121

    authors: Houston SM,Lebel C,Katzir T,Manis FR,Kan E,Rodriguez GG,Sowell ER

    更新日期:2014-03-26 00:00:00

  • Dissociable modulating effect of repetitive transcranial magnetic stimulation on sensory and pain perception.

    abstract::The effects of high frequency repetitive transcranial magnetic stimulation on sensory perception and the pain tolerance thresholds were investigated applying both motor cortex stimulation and medial frontal cortex stimulation in normal study participants. Both the sensory perception and pain tolerance thresholds were ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/01.wnr.0000198438.37012.d6

    authors: Yoo WK,Kim YH,Doh WS,Lee JH,Jung KI,Park DS,Park ES

    更新日期:2006-02-06 00:00:00

  • Huperzine A, a novel promising acetylcholinesterase inhibitor.

    abstract::The effects of huperzine A on memory impairments induced by scopolamine were evaluated using a radial maze task and inhibition of cholinesterase in vitro compared with the effects of E2020 and tacrine. Scopolamine (0.2 mg kg-1) significantly impaired spatial memory in rats. Huperzine A (0.1-0.4 mg kg-1, p.o.), E2020 (...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199612200-00020

    authors: Cheng DH,Ren H,Tang XC

    更新日期:1996-12-20 00:00:00

  • Modelling transfer characteristics of vestibular neurons in the fastigial nucleus of the behaving monkey on the basis of canal-otolith interaction.

    abstract::The interaction of vestibular inputs with different dynamic and spatial behavior, i.e., canal-otolith interaction, leads to spatio-temporal convergence. Vestibular neurons in the fastigial nucleus often exhibit spatio-temporal convergence. The present report demonstrates that the discharge rates of most vestibular neu...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200205070-00013

    authors: Wilden A,Glasauer S,Kleine JF,Büttner U

    更新日期:2002-05-07 00:00:00

  • Processing social participation: an event-related brain potential study.

    abstract::We examined the electrophysiological correlates of the processing of social exclusion and inclusion by using a modified version of the Cyberball paradigm. Exclusion was found to be associated with a significant increase in the P3 complex. The frontal-central P3a was primarily related to the affective processing of rej...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e3283476b67

    authors: Gutz L,Küpper C,Renneberg B,Niedeggen M

    更新日期:2011-06-22 00:00:00

  • Time of transforming growth factor beta 1 inoculation alters the incubation of BSE in mice.

    abstract::Groups of 20 C57BL/6J mice (10 males and 10 females) were given BSE strain 301C i.p. and subsequently given 2 microg recombinant human TGFbeta1 s.c. at single or multiple times. There was a significant positive correlation between the day of TGFbeta1 administration and incubation time; the later TGFbeta1 was administe...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200410050-00018

    authors: Kempster S,Collins ME,Edington N

    更新日期:2004-10-05 00:00:00

  • Innervation of stem cell-derived neurons into auditory epithelia of mice.

    abstract::This study examined the potential of embryonic stem cell-derived neurons as transplants for cell therapy for the primary loss of spiral ganglion neurons. To assess the ability of embryonic stem cell-derived neurons for innervation into auditory epithelia, they were cocultured with auditory epithelium explants of mice ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200505310-00001

    authors: Matsumoto M,Nakagawa T,Higashi T,Kim TS,Kojima K,Kita T,Sakamoto T,Ito J

    更新日期:2005-05-31 00:00:00

  • Improvement in γ-hydroxybutyrate-induced contextual fear memory deficit by systemic administration of NCS-382.

    abstract::Low, nonsedative doses of γ-hydroxybutyric acid (GHB) produce short-term anterograde amnesia in humans and memory impairments in experimental animals. We have previously shown that acute systemic treatment of GHB in adolescent female rats impairs the acquisition, but not the expression, of contextual fear memory while...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000000586

    authors: Ishiwari K,Sircar R

    更新日期:2016-06-15 00:00:00

  • Involvement of vision in tool use in crow.

    abstract::Birds are capable of dexterous sensory-motor activities such as tool use. Reaching is a crucial component of tool use and is a vision-guided behavior in primates, in which arm movement is monitored online in a stable visual frame. However, vision-guided reaching in primates is enabled by anatomical separation of the h...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000000229

    authors: Kanai M,Matsui H,Watanabe S,Izawa E

    更新日期:2014-09-10 00:00:00

  • MK-801 does not enhance dopaminergic cell survival in embryonic nigral grafts.

    abstract::Two groups of hemiparkinsonian rats received grafts of embryonic ventral mesencephalon with or without the addition of the NMDA receptor antagonist (+)dizocilpine hydrogen maleate (MK-801). When added to the cell suspension, a 10 microM concentration of MK-801 did not enhance the survival of tyrosine hydroxylase posit...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199805110-00011

    authors: Schierle GS,Karlsson J,Brundin P

    更新日期:1998-05-11 00:00:00

  • Olfactory neurons in vitro show phenotypic orientation in epithelial spheres.

    abstract::Production and differentiation of olfactory neurons occur in spherical, multi-neuronal aggregates that form in cultures where dissociated newborn rat nasal cells are plated on to CNS glial cells. We show here that neuronal cell bodies were primarily located in the peripheral layers of the spheres, and almost every neu...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199401000-00003

    authors: Pixley SK,Bage M,Miller D,Miller ML,Shi M,Hastings L

    更新日期:1994-01-31 00:00:00

  • 192 IgG-saporin abolishes p75 neurotrophin receptor immunoreactivity in rat SCN.

    abstract::The rat suprachiasmatic (SCN) contains a dense plexus of low-affinity p75 neurotrophin receptor (p75NTR)-immunoreactivity. In some SCN neurons, p75NTR is co-localized with vasoactive intestinal peptide (VIP). The present study examines the effect of third ventricle administration of 192 IgG-saporin immunotoxin on p75N...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199810050-00012

    authors: Moga MM

    更新日期:1998-10-05 00:00:00

  • Acute adaptive changes in food intake pattern following olfactory ablation in rats.

    abstract::We determined whether acute compensatory feeding pattern changes after bulbectomy persist on a chronic basis, or whether physiological adaptation occurs to normalize acute changes. Rats were randomized to olfactory bulbectomy or sham operation; all had jugular vein catheterization. Food intake, meal number and size we...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199704140-00023

    authors: Meguid MM,Koseki M,Yang ZJ,Gleason JR,Laviano A

    更新日期:1997-04-14 00:00:00

  • Functional asymmetry of superior parietal lobule for working memory in the elderly.

    abstract::The relation between neuronal activity in the superior parietal lobule with working memory capacity in an elderly population was investigated. Using functional magnetic resonance imaging we examined effects associated with the performance of a reading span test and individual differences in executive function and shor...

    journal_title:Neuroreport

    pub_type: 临床试验,杂志文章

    doi:10.1097/WNR.0b013e32830e000f

    authors: Otsuka Y,Osaka N,Osaka M

    更新日期:2008-09-17 00:00:00

  • Participation of low-threshold Ca2+ spike in the Purkinje cells complex spike.

    abstract::In Purkinje cells from cerebellar slice cultures, low-threshold Ca spike (LTS) gives rise to complex bursts in the soma that resemble the complex spike induced by climbing fibers stimulation. We show that LTS is reduced by T-type and R-type Ca channel blockers (SNX-482, nickel, or mibefradil). We propose that LTS is g...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e3282f4cb96

    authors: Cavelier P,Lohof AM,Lonchamp E,Beekenkamp H,Mariani J,Bossu JL

    更新日期:2008-02-12 00:00:00

  • An implantable device for neuropsychiatric rehabilitation by chronic deep brain stimulation in freely moving rats.

    abstract::Successful practice of clinical deep brain stimulation (DBS) calls for basic research on the mechanisms and explorations of new indications in animals. In the article, a new implantable, single-channel, low-power miniature device is proposed, which may transmit pulses chronically into the brain nucleus of freely movin...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000000727

    authors: Liu H,Wang C,Zhang F,Jia H

    更新日期:2017-02-08 00:00:00

  • fMRI of human somatosensory and cingulate cortex during painful electrical nerve stimulation.

    abstract::Functional MRI (fMRI) can detect changes from resting levels of blood flow and oxygenation during task performance (i.e. activation). We used a simple electrical nerve stimulation technique together with fMRI to study pain process in the human cortex. Images of the primary somatosensory (SI) and cingulate cortex (Cg) ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:

    authors: Davis KD,Wood ML,Crawley AP,Mikulis DJ

    更新日期:1995-12-29 00:00:00

  • Event-related potentials in an emotional go/no-go task and remission of geriatric depression.

    abstract::Anterior cingulate integrity may be required for antidepressant response. To assess anterior cingulate processes related to treatment response, we studied error-related negativity and error positivity produced during an emotional go/no-go challenge, a task activating the rostral anterior cingulate. Twelve elderly pati...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e328013ceda

    authors: Alexopoulos GS,Murphy CF,Gunning-Dixon FM,Kalayam B,Katz R,Kanellopoulos D,Etwaroo GR,Klimstra S,Foxe JJ

    更新日期:2007-02-12 00:00:00

  • Cellular localization of hydroxyindole-O-methyltransferase mRNA in the chicken pineal gland.

    abstract::Hydroxyindole-O-methyltransferase (HIOMT), is the last enzyme of the melatonin biosynthesis pathway. We have applied immunocytochemistry and in situ hybridization to localize HIOMT producing cells, in the chicken epithalamus including the pineal gland. The selectivity of the hybridization signal over melatoninergic ce...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199306000-00052

    authors: Grève P,Bernard M,Voisin P,Cogné M,Collin JP,Guerlotte J

    更新日期:1993-06-01 00:00:00

  • Noradrenergic inputs enhance the response of neurosecretory cells to osmotic stimulation.

    abstract::Extracellular recordings from neurosecretory cells in the hypothalamic paraventricular nucleus (PVN) displayed either an excitation or no response following electrical stimulation (5 Hz) of the A1 noradrenergic region of the ventrolateral medulla, and exhibited either an increase or no effect in neuronal activity in r...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199203000-00010

    authors: Tanaka J,Nomura M,Saito H

    更新日期:1992-03-01 00:00:00

  • Rotation-induced conditioned rejection in the taste reactivity test.

    abstract::The taste reactivity test was used to evaluate the ability of motion sickness to produce conditioned rejection reactions, a putative measure of nausea in rats. Following three conditioning trials, rats displayed conditioned rejection reactions during an intraoral infusion of a rotation-paired saccharin solution. This ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199905140-00030

    authors: Cordick N,Parker LA,Ossenkopp KP

    更新日期:1999-05-14 00:00:00

  • Functional brain mapping of the relaxation response and meditation.

    abstract::Meditation is a conscious mental process that induces a set of integrated physiologic changes termed the relaxation response. Functional magnetic resonance imaging (fMRI) was used to identify and characterize the brain regions that are active during a simple form of meditation. Significant (p<10(-7)) signal increases ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:

    authors: Lazar SW,Bush G,Gollub RL,Fricchione GL,Khalsa G,Benson H

    更新日期:2000-05-15 00:00:00

  • Luminance adaptation increased the contrast sensitivity of retinal ganglion cells.

    abstract::In the present study, the activity changes of chicken retinal ganglion cells in response to light stimuli with defined contrast were investigated, in the presence of various levels of sustained background illumination. Following a step increase of light illumination, the firing rate of most retinal ganglion cells incr...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200503150-00013

    authors: Chen AH,Zhou Y,Gong HQ,Liang PJ

    更新日期:2005-03-15 00:00:00

  • Corpus callosum: musician and gender effects.

    abstract::Previously we found that musicians have significantly larger anterior corpus callosum (CC). In the current study, we intended to replicate and extend our previous results using a new and larger sample of gender-matched subjects (56 right-handed professional musicians and 56 age- and handedness-matched controls). We fo...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200302100-00009

    authors: Lee DJ,Chen Y,Schlaug G

    更新日期:2003-02-10 00:00:00

  • Neuroinflammation in the pathogenesis of amyotrophic lateral sclerosis.

    abstract::Amyotrophic lateral sclerosis is a devastating motor neuron disorder. Traditionally regarded as a 'neuron only' disease, recent evidence suggested that other cells contribute critically to the pathogenesis. This review provides a short synopsis of the role neuroinflammation and microglial cells play in the disease and...

    journal_title:Neuroreport

    pub_type: 杂志文章,评审

    doi:10.1097/00001756-200504250-00001

    authors: Weydt P,Möller T

    更新日期:2005-04-25 00:00:00

  • c-Fos expression in the cholinergic basal forebrain after enforced wakefulness and recovery sleep.

    abstract::The present study used c-Fos expression to examine cellular activity in cholinergic regions in the basal forebrain (BF) following enforced waking and recovery sleep. Cholinergic cells within the vertical and horizontal limbs of the diagonal band of Broca (VDB and HDB, respectively) showed significantly higher c-Fos im...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200002280-00002

    authors: Greco MA,Lu J,Wagner D,Shiromani PJ

    更新日期:2000-02-28 00:00:00

  • Brainstem microstimulation activates sympathetic fibers in pudendal nerve motor branch.

    abstract::A bilateral spino-bulbo-spinal circuit conveys information from/to the male urogenital tract and perineal muscles. This is the first electrophysiological report of another descending pathway, one which conveys output from the medullary reticular formation (MRF) to activate postganglionic sympathetic fibers contained w...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200002070-00031

    authors: Johnson RD,Hubscher CH

    更新日期:2000-02-07 00:00:00

  • Long-term disuse of the hand affects motor imagery ability in patients with complete brachial plexus palsy.

    abstract::The purpose of this study was to examine motor imagery ability in patients with peripheral nerve disorder using the hand mental rotation task. Five patients with left total avulsion brachial plexus palsy (BPP) and 16 healthy age-matched adults participated in this study. The mean±SD time from the injury was 103.6±49.7...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000001229

    authors: Date S,Kurumadani H,Yoshimura M,Fukae A,Onishi K,Hayashi J,Shinomiya R,Sunagawa T

    更新日期:2019-04-10 00:00:00

  • Photochemical stroke and brain-derived neurotrophic factor (BDNF) mRNA expression.

    abstract::In situ hybridization and Northern blotting were used to study the expression of brain-derived neurotrophic factor (BDNF) mRNA in the rat brain following photochemical stroke. A focal thrombotic lesion of the sensorimotor cortex was produced by intravenously injecting the light-sensitive dye rose bengal and exposing t...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199206000-00004

    authors: Comelli MC,Seren MS,Guidolin D,Manev RM,Favaron M,Rimland JM,Canella R,Negro A,Manev H

    更新日期:1992-06-01 00:00:00

  • Can color changes alter the neural correlates of recognition memory? Manipulation of processing affects an electrophysiological indicator of conceptual implicit memory.

    abstract::It has been widely shown that recognition memory includes two distinct retrieval processes: familiarity and recollection. Many studies have shown that recognition memory can be facilitated when there is a perceptual match between the studied and the tested items. Most event-related potential studies have explored the ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000000652

    authors: Cui X,Gao C,Zhou J,Guo C

    更新日期:2016-09-28 00:00:00