Abstract:
:We have previously suggested that progranulin mediates the stimulatory effects of estrogen on adult neurogenesis in the hippocampus. Neurogenesis in mature animals is enhanced by growth factors, environmental enrichment, and voluntary exercise. In this study, we investigated the role of progranulin in voluntary running-induced hippocampal neurogenesis. In the hippocampus of wild-type mice, the pyramidal neurons in the CA1 and CA3 regions and interneurons in the hilus were mainly immunoreactive for progranulin, and wheel running increased progranulin expression in these neurons. Wheel running also increased the number of proliferating cells in the hippocampus in wild-type mice, but not in progranulin-deficient mice. These results suggest that progranulin plays an indispensable role in enhancing the hippocampal neurogenesis induced by voluntary exercise.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Asakura R,Matsuwaki T,Shim JH,Yamanouchi K,Nishihara Mdoi
10.1097/WNR.0b013e32834bf4casubject
Has Abstractpub_date
2011-12-07 00:00:00pages
881-6issue
17eissn
0959-4965issn
1473-558Xjournal_volume
22pub_type
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