Abstract:
:Sciatic nerve resection leaving a 15 mm gap could not be repaired by bridging the stumps with a silicone tube prefilled with a laminin gel. However, when purified olfactory ensheathing cells (EC) were added to the gel filling the tube, successful axonal regeneration was observed in 50% of rats. With 12 mm gaps, regeneration occurred in 79% of rats with transplanted EC compared with 60% of those receiving collagen gel alone. Therefore, ECs help repair severe peripheral nerve injuries, in addition to their ability to promote axonal regeneration within the central nervous system.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Verdú E,Navarro X,Gudiño-Cabrera G,Rodríguez FJ,Ceballos D,Valero A,Nieto-Sampedro Mdoi
10.1097/00001756-199904060-00035subject
Has Abstractpub_date
1999-04-06 00:00:00pages
1097-101issue
5eissn
0959-4965issn
1473-558Xjournal_volume
10pub_type
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