Olfactory bulb ensheathing cells enhance peripheral nerve regeneration.

Abstract:

:Sciatic nerve resection leaving a 15 mm gap could not be repaired by bridging the stumps with a silicone tube prefilled with a laminin gel. However, when purified olfactory ensheathing cells (EC) were added to the gel filling the tube, successful axonal regeneration was observed in 50% of rats. With 12 mm gaps, regeneration occurred in 79% of rats with transplanted EC compared with 60% of those receiving collagen gel alone. Therefore, ECs help repair severe peripheral nerve injuries, in addition to their ability to promote axonal regeneration within the central nervous system.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Verdú E,Navarro X,Gudiño-Cabrera G,Rodríguez FJ,Ceballos D,Valero A,Nieto-Sampedro M

doi

10.1097/00001756-199904060-00035

subject

Has Abstract

pub_date

1999-04-06 00:00:00

pages

1097-101

issue

5

eissn

0959-4965

issn

1473-558X

journal_volume

10

pub_type

杂志文章
  • Sound perception affected by nonlinear variation of accuracy in memory trace.

    abstract::The mismatch negativity (MMN) reflects the neural representation of the acoustic environment stored in sensory memory. The short phase of sensory memory corresponds to the temporal window of integration (TWI) which integrates the neighboring sounds into a unitary event. We measured the magnetic MMN (MMNm) and the disc...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:

    authors: Yabe H,Asai R,Hiruma T,Sutoh T,Koyama S,Kakigi R,Tervaniemi M,Kaneko S

    更新日期:2004-12-22 00:00:00

  • Purkinje cell loss accompanies motor impairment in rats developing at altered gravity.

    abstract::We have previously reported that the developmental exposure of rats to altered gravity (1.65 g) from gestational day 8 to postnatal day 21 impacts motor functions and cerebellar structure. The present study examined whether the decrease in cerebellar mass accompanied by impaired performance on a rotorod in hypergravit...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200512190-00014

    authors: Sajdel-Sulkowska EM,Nguon K,Sulkowski ZL,Rosen GD,Baxter MG

    更新日期:2005-12-19 00:00:00

  • Muscarinic cholinoceptive reticular mechanisms and parabrachial neuron discharge: a novel experimental approach.

    abstract::This study examined the hypothesis that cholinergic receptor mechanisms within the gigantocellular tegmental field (FTG) of the medial pontine reticular formation can cause state-dependent changes in the firing rates of parabrachial nuclear complex (PBNC) neurons. Using intact, unanesthetized cats, long-term recording...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199303000-00011

    authors: Gilbert KA,Lydic R

    更新日期:1993-03-01 00:00:00

  • SIRT2 mediates oxidative stress-induced apoptosis of differentiated PC12 cells.

    abstract::Sirtuin 2 (SIRT2) is a member of the sirtuin family. Previous studies have suggested that SIRT2 mediates the cell death in models of Parkinson's disease and Huntington's disease. However, the role of SIRT2 in oxidative stress-induced cell death has remained unclear. In this study, we investigated the roles of SIRT2 in...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000000192

    authors: Nie H,Hong Y,Lu X,Zhang J,Chen H,Li Y,Ma Y,Ying W

    更新日期:2014-08-06 00:00:00

  • Bax and Bak proteins require caspase activity to trigger apoptosis in sympathetic neurons.

    abstract::We show that the pro-apoptotic proteins Bax and Bak trigger apoptosis when over-expressed in sympathetic neurons cultured in the presence of NGF. This effect can be blocked with z-VAD-fmk, a peptide inhibitor of caspases, but not with anti-apoptotic chemical compounds such as antioxidants or proteasome inhibitors. The...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199801050-00004

    authors: Martinou I,Missotten M,Fernandez PA,Sadoul R,Martinou JC

    更新日期:1998-01-05 00:00:00

  • ADP-ribosylation of myelin basic proteins isolated from normal and mutant mouse brains.

    abstract::Myelin basic proteins (MBPs) have been shown to be ADP-ribosylated in-vitro by cholera toxin in the presence of NAD. Since acid-soluble extracts of brain contain other proteins in the 14-32 kD range (such as histones) in addition to MBP's, the identification of the ADP-ribosylated proteins was uncertain. To determine ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199011000-00012

    authors: Boulias C,Moscarello MA

    更新日期:1990-11-01 00:00:00

  • Blockade of joint inflammation and secondary hyperalgesia by L-NAME, a nitric oxide synthase inhibitor.

    abstract::Acute arthritis is associated with pain-related behavior, joint swelling and increased joint temperature. Arthritic animals exhibit a significant decrease in paw withdrawal latency 4, 5, 6, 7 and 8 h after induction of inflammation, when compared with baseline values, indicative of secondary hyperalgesia. Intra-articu...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199703030-00016

    authors: Lawand NB,Willis WD,Westlund KN

    更新日期:1997-03-03 00:00:00

  • Metabotropic glutamate receptor agonists reduce epileptiform activity in the rat cortex.

    abstract::Slices of rat cingulate cortex, when incubated in magnesium-free medium, produce spontaneous epileptiform spikes. Here it is demonstrated that the metabotropic glutamate receptor (mGluR) agonists +/- trans-1-amino-cyclopentane-1,3-dicarboxylic acid (+/- Trans-ACPD), IS3R-ACPD and quisqualic acid (quis) can reduce the ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199210000-00024

    authors: Sheardown MJ

    更新日期:1992-10-01 00:00:00

  • Delayed epileptogenesis in nociceptin/orphanin FQ-deficient mice.

    abstract::The neuropeptide nociceptin/orphanin FQ (N/OFQ) is implicated in many biological functions, including nociception, locomotor activity, stress and anxiety, drinking and food-intake. N/OFQ has also been reported to play a facilitatory role in acute kainate-induced seizures. The aim of the present study was to investigat...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200305060-00009

    authors: Binaschi A,Zucchini S,Bregola G,Rodi D,Mazzuferi M,Reinscheid RK,Simonato M

    更新日期:2003-05-06 00:00:00

  • Oleic acid enhances ACh receptor currents by activation of Ca2+/calmodulin-dependent protein kinase II.

    abstract::Oleic acid, a cis-unsaturated free fatty acid, is proposed to be involved in the protein kinase C (PKC) activation pathway. Its biological actions, however, have not been well-characterized. We examined the effects of oleic acid on acetylcholine (ACh)-gated channel currents using Torpedo nicotinic ACh receptors expres...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199702100-00004

    authors: Nishizaki T,Ikeuchi Y,Matsuoka T,Sumikawa K

    更新日期:1997-02-10 00:00:00

  • Dose-response of rt-PA and its combination with aspirin in a rat embolic stroke model.

    abstract::The efficacy and safety of thrombolysis with different dose regimens of recombinant tissue plasminogen activator (rt-PA) and its combination with aspirin was tested in an embolic stroke model. In rats the carotid territory was embolized with a single clot formed in a polyethylene tube and washed with saline. Fifteen m...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199210000-00027

    authors: Overgaard K,Sereghy T,Pedersen H,Boysen G

    更新日期:1992-10-01 00:00:00

  • Induced brain magnetic activities related to salient birdsong under noisy conditions.

    abstract:OBJECTIVE:Birdsong sounds are often used to inform visually-challenged people about the presence of basic infrastructures, and therefore need to be salient in noisy urban environments. How salient sounds are processed in the brain could inform us about the optimal birdsong in such environments. However, brain activity ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000001563

    authors: Yano H,Soeta Y

    更新日期:2021-01-13 00:00:00

  • Evidence for a modulatory role of Ih on the firing of a subgroup of midbrain dopamine neurons.

    abstract::A previous investigation has suggested that the hyperpolarization-activated cation current Ih does not contribute to the spontaneous firing of midbrain dopaminergic neurons. This conclusion was reached using Cs(-1). We have re-examined this question with extracellular recordings in slices using the more specific block...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200102120-00015

    authors: Seutin V,Massotte L,Renette MF,Dresse A

    更新日期:2001-02-12 00:00:00

  • Expression of Nogo receptor 1 in the regeneration process of the mouse olfactory epithelium.

    abstract::Nogo receptor 1 (NgR1) is the most important Nogo-A receptor. By its interaction with myelin-associated inhibitory proteins, NgR1 inhibits the regeneration of axons and is extensively expressed in the central nervous system. However, the expression of NgR1 in regenerable neurons, such as olfactory neurons, and its exp...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000000580

    authors: Chen HX,Zeng XP,Sun YQ,Fu QL

    更新日期:2016-07-06 00:00:00

  • Attentional switching-related human EEG alpha oscillations.

    abstract::Alpha oscillations during cognitive performance have mostly been studied in memory and/or basic attention tasks. This study investigates task-related alpha power desynchronization during an attentional switching task requiring higher executive attentional control. Low 8-10 Hz and high 10-12 Hz alpha power responses ar...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200204160-00029

    authors: Verstraeten E,Cluydts R

    更新日期:2002-04-16 00:00:00

  • Novel splice variants of the voltage-sensitive sodium channel alpha subunit.

    abstract::In this study, we have identified novel splice variants of the Na+ channel alpha subunit mRNA from cultured rat astrocytes and neuroblastoma cells. These splice variants are characterized by premature truncation or deletion of a segment in the third domain of the Na+ channel alpha subunit. The expression of three spli...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199805110-00002

    authors: Oh Y,Waxman SG

    更新日期:1998-05-11 00:00:00

  • Dorsal, but not ventral, hippocampal lesions disrupt cocaine place conditioning.

    abstract::The environment in which cocaine is experienced becomes associated with the effects of the drug and can then elicit cocaine craving. This study examined whether the hippocampus is involved in such associations using the conditioned place preference model. Rats received bilateral lesions of the dorsal or ventral hippoc...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200311140-00023

    authors: Meyers RA,Zavala AR,Neisewander JL

    更新日期:2003-11-14 00:00:00

  • Changes in insular cortex metabolites in patients with obstructive sleep apnea syndrome.

    abstract::The aim of this study was to investigate the changes in insular cortex metabolites and the correlation with clinical manifestations in patients with obstructive sleep apnea syndrome (OSA). Lateral insular metabolite levels were measured and relevant ratios were calculated in OSA patients and healthy individuals, inclu...

    journal_title:Neuroreport

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/WNR.0000000000001065

    authors: Kang J,Tian Z,Li M

    更新日期:2018-08-15 00:00:00

  • Effect of hypothermia on microglial reaction in ischemic brain.

    abstract::Intra-ischemic hypothermia is known to protect neurons against ischemic injury. Microglial cells have been shown to become activated following ischemia and are speculated to play significant roles in the evolution of ischemic neuronal injury. In this study, we examined the effect of intra-ischemic hypothermia on the m...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199703030-00026

    authors: Kumar K,Evans AT

    更新日期:1997-03-03 00:00:00

  • Inhibition of microRNA-429 attenuates oxygen-glucose deprivation/reoxygenation-induced neuronal injury by promoting expression of GATA-binding protein 4.

    abstract::MicroRNAs (miRNAs) have been documented as critical regulators in ischemia/reperfusion-induced neuronal death. A better understanding of miRNA-mediated molecular mechanisms in ischemia/reperfusion-induced neuronal death may provide therapeutic targets for cerebral ischemia/reperfusion injury. A growing body of evidenc...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000001023

    authors: Xiao J,Kong R,Hu J

    更新日期:2018-06-13 00:00:00

  • Activation of inwardly rectifying K+ channels by GABA-B receptors expressed in Xenopus oocytes.

    abstract::In Xenopus oocytes coinjected with poly(A)+ RNA derived from the rat cerebellum and cRNAs for the cloned G protein-gated inwardly rectifying K+ channel (GIRK), GIRK1 and GIRK2, the GABA-B agonist baclofen elicited inwardly rectifying K+ currents. The inward K+ currents elicited by baclofen were inhibited by the select...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199803090-00004

    authors: Uezono Y,Akihara M,Kaibara M,Kawano C,Shibuya I,Ueda Y,Yanagihara N,Toyohira Y,Yamashita H,Taniyama K,Izumi F

    更新日期:1998-03-09 00:00:00

  • New aspects of motion perception: selective neural encoding of apparent human movements.

    abstract::Perception of apparent motion operates somewhat differently for objects and human figures. Depending on the interstimulus interval, the latter d may give rise to either perception of a direct path (i.e. biologically impossible) or indirect path (i.e. biologically possible). Here, PET was used to investigate whether a ...

    journal_title:Neuroreport

    pub_type: 临床试验,杂志文章

    doi:10.1097/00001756-200001170-00022

    authors: Stevens JA,Fonlupt P,Shiffrar M,Decety J

    更新日期:2000-01-17 00:00:00

  • Preferential expression of IGF-I in small DRG neurons and down-regulation following injury.

    abstract::In this study, we examined the expression of insulin-like growth factor I (IGF-I) and its receptor (IGF-IR) in dorsal root ganglia (DRG) neurons in two rodent models of nerve injury: sciatic nerve axotomy and streptozotocin-induced (STZ) painful diabetic neuropathy. We demonstrate that IGF-I and its receptor are prefe...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200209160-00016

    authors: Craner MJ,Klein JP,Black JA,Waxman SG

    更新日期:2002-09-16 00:00:00

  • Response amplification in sensory-specific cortices during crossmodal binding.

    abstract::Integrating information across the senses can enhance our ability to detect and classify stimuli in the environment. For example, auditory speech perception is substantially improved when the speaker's face is visible. In an fMRI study designed to investigate the neural mechanisms underlying these crossmodal behaviour...

    journal_title:Neuroreport

    pub_type: 临床试验,杂志文章

    doi:10.1097/00001756-199908200-00033

    authors: Calvert GA,Brammer MJ,Bullmore ET,Campbell R,Iversen SD,David AS

    更新日期:1999-08-20 00:00:00

  • GPR39 receptor expression in the mouse brain.

    abstract::GPR39, an orphan G protein-coupled receptor, has been recently identified as the receptor for the bioactive peptide obestatin. Obestatin is secreted from the stomach and acts as an anti-appetite hormone. This activity is induced whether obestatin is administered intraperitoneally or intracerebroventricularly. GPR39 is...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/01.wnr.0000215779.76602.93

    authors: Jackson VR,Nothacker HP,Civelli O

    更新日期:2006-05-29 00:00:00

  • Moving tactile stimuli of fingers are integrated in the intraparietal and inferior parietal cortices.

    abstract::When two cylinders are passively moved in-phase on the volar surface of the right second and third fingers, human subjects estimate the stimuli to originate from one object, whereas two separate objects are estimated for out-of-phase stimuli. While five blindfolded subjects performed this estimation task, brain activi...

    journal_title:Neuroreport

    pub_type: 临床试验,杂志文章

    doi:10.1097/00001756-200304150-00012

    authors: Kitada R,Kochiyama T,Hashimoto T,Naito E,Matsumura M

    更新日期:2003-04-15 00:00:00

  • A suprachiasmatic nucleus projecting retinal ganglion cell exhibits an unusually large dendritic field in the hamster.

    abstract::The majority of retinal ganglion cells innervating the suprachiasmatic nucleus are intrinsically light sensitive, while the rest are conventional ganglion cells that collect inputs through conventional photoreceptors. Here we report a rarely encountered ganglion cell that had a dendritic field covering approximately 1...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/01.wnr.0000234757.26610.e8

    authors: Pu M,Chen B,Li RS,Tay D,So KF

    更新日期:2006-10-02 00:00:00

  • YM-50001: a novel, potent and selective dopamine D4 receptor antagonist.

    abstract::We investigated some in vitro pharmacological properties of a novel human dopamine D2-like receptor antagonist, YM-50001 [(R)-5-chloro-4-cyclopropylacarbonylamino-2-methoxy-N-[1-(3-methox ybenzyl)- 3-pyrrolidinyl]benzamide monooxalate]. Receptor binding studies revealed that YM-50001 had a potent affinity for human D4...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:

    authors: Hidaka K,Tada S,Matsumoto M,Ohmori J,Maeno K,Yamaguchi T

    更新日期:1996-11-04 00:00:00

  • The influence of nodal constriction on conduction velocity in myelinated nerve fibers.

    abstract::Myelinated nerve fibers exhibit a complex anatomy in the nodal region which includes a marked nodal-paranodal constriction and an intricate paranodal structure where the myelin sheath is separated from the axon by a narrow periaxonal space. In this study, a recently developed computational model of the mammalian myeli...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199301000-00023

    authors: Halter JA,Clark JW Jr

    更新日期:1993-01-01 00:00:00

  • Baclofen decreases methamphetamine self-administration in rats.

    abstract::In the present study we tested the hypothesis that baclofen, a GABA-B receptor agonist, attenuates methamphetamine self-administration. Fifteen rats were trained to self-administer i.v. injections of methamphetamine (0, 0.0625, 0.125 and 0.25 mg/kg/injection) on a progressive ratio schedule of reinforcement, and then ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200207020-00007

    authors: Ranaldi R,Poeggel K

    更新日期:2002-07-02 00:00:00