Expression of Nogo receptor 1 in the regeneration process of the mouse olfactory epithelium.

Abstract:

:Nogo receptor 1 (NgR1) is the most important Nogo-A receptor. By its interaction with myelin-associated inhibitory proteins, NgR1 inhibits the regeneration of axons and is extensively expressed in the central nervous system. However, the expression of NgR1 in regenerable neurons, such as olfactory neurons, and its expression in the regeneration progress of olfactory neurons have not been reported. In this study, we demonstrated that NgR1 was expressed in the cell bodies of certain mature olfactory receptor neurons (ORNs) but was not expressed in immature ORNs in the olfactory epithelium (OE) of normal adult mice. On day 21 after OE injury, NgR1 was expressed not only in the cell bodies of mature ORNs but also in the cell bodies of glial fibrillary acidic protein (GFAP)-positive cells in the top and submucosal layers of the OE. On day 48 after model establishment, NgR1 expression decreased in the cell bodies of the GFAP-positive cells. On day 56 after model establishment, no NgR1 expression was found in the cell bodies of the GFAP-positive cells, and NgR1 was again expressed only in the mature ORNs. Our results demonstrated that NgR1 expression is upregulated in the OE after injury, which suggests that NgR1 might be involved in the regeneration of the OE.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Chen HX,Zeng XP,Sun YQ,Fu QL

doi

10.1097/WNR.0000000000000580

subject

Has Abstract

pub_date

2016-07-06 00:00:00

pages

717-23

issue

10

eissn

0959-4965

issn

1473-558X

journal_volume

27

pub_type

杂志文章
  • Paraventricular nucleus injections of naloxone methiodide inhibit NPY's effects on energy substrate utilization.

    abstract::Microinjection of neuropeptide Y (NPY) into the paraventricular nucleus (PVN) of the hypothalamus stimulates eating and increases respiratory quotient. In contrast, administration of opioid receptor antagonists reduces food intake and suppresses NPY-induced feeding. The present study examined whether naloxone methiodi...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200003200-00016

    authors: Currie PJ,Coscina DV,Moretti J,Avellino MD

    更新日期:2000-03-20 00:00:00

  • Colour recognition at large visual eccentricities in normal observers and patients with low vision.

    abstract::When we look at our spatial environment we have the feeling that the whole visual field is coloured, yet the density of cone photoreceptors decreases considerably as eccentricity increases. We investigated colour perception (coloured/noncoloured), colour naming and whether colour helps object recognition at eccentrici...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/01.wnr.0000236864.54575.98

    authors: Naïli F,Despretz P,Boucart M

    更新日期:2006-10-23 00:00:00

  • Age-dependent changes in distribution of P3a/P3b amplitude and thickness of the cerebral cortex.

    abstract::With increasing age, the electrophysiological event-related potentials P3a/P3b tend to get a more frontal maximum. The cognitive significance of this so-called frontal shift is not known, but hypotheses have focused on changes in the integrity of the frontal lobes. The aim of the present study was to test how the thic...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/01.wnr.0000177011.44602.17

    authors: Fjell AM,Walhovd KB,Reinvang I

    更新日期:2005-09-08 00:00:00

  • NMDA receptor subunit and CaMKII changes in rat hippocampus by congenital HCMV infection: a mechanism for learning and memory impairment.

    abstract::The aim of this study was to investigate the effects of congenital human cytomegalovirus infection on the expression levels of N-methyl-D-aspartate receptors (NRs) and Ca/calmodulin-dependent protein kinase II (CaMKII) in the hippocampal neurons of neonatal Sprague-Dawley (SD) rats. Pregnant SD rats were divided into ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000000750

    authors: Wu,Yang L,Bu X,Tang J,Fan X

    更新日期:2017-03-22 00:00:00

  • Prenatal ethanol exposure does not cause neurological alterations in adult CD1 mice.

    abstract::Genetic factors are involved in variation in fetal alcohol spectrum disorders (FASD), which is also observed among various inbred mouse strains. The CD1 mouse strain is often used in toxicological and genetic experiments. However, there is little literature using this strain to study long-term neurologic abnormalities...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e32835e3258

    authors: Wei S,Xu Z,Gao J,Ding J,Xiao M

    更新日期:2013-03-06 00:00:00

  • Distinctive neuronal organization of the olfactory bulb of the laboratory shrew.

    abstract::The organization of the main olfactory bulb of an insectivore, the laboratory shrew (Suncus murinus), was studied morphologically. We found particular small spherical regions, nidi, at the border between the glomerular and external plexiform layer (EPL), which were intensely GAD positive, 30-60 microm in diameter, and...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199902050-00012

    authors: Kosaka K,Kosaka T

    更新日期:1999-02-05 00:00:00

  • Combining findings from gaze and electroencephalography recordings to study timing in a visual tracking task.

    abstract::Electroencephalography (EEG) and gaze data have traditionally been separated in neurocognitive studies because of the artefacts that even small controlled eye movements produce. Study of gaze control in a visual tracking task provides information about an individual's prospective control. By including gaze events in t...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000000020

    authors: Holth M,van der Meer AL,van der Weel FR

    更新日期:2013-12-04 00:00:00

  • Cerebral hemodynamics during electrically induced seizures.

    abstract::Electroconvulsive therapy (ECT) is an appropriate clinical model to investigate blood flow during seizures. In this study cerebral blood flow velocity (CBFV) was measured during 40 ECTs in 10 patients by means of transcranial Doppler sonography. EEG was recorded continuously. Under general anesthesia, the pre-convulsi...

    journal_title:Neuroreport

    pub_type: 临床试验,杂志文章

    doi:10.1097/00001756-199802160-00009

    authors: Vollmer-Haase J,Folkerts HW,Haase CG,Deppe M,Ringelstein EB

    更新日期:1998-02-16 00:00:00

  • Curcumin mitigates axonal injury and neuronal cell apoptosis through the PERK/Nrf2 signaling pathway following diffuse axonal injury.

    abstract::Diffuse axonal injury (DAI) accounts for more than 50% of all traumatic brain injury. In response to the mechanical damage associated with DAI, the abnormal proteins produced in the neurons and axons, namely, β-APP and p-tau, induce endoplasmic reticulum (ER) stress. Curcumin, a major component extracted from the rhiz...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000001015

    authors: Huang T,Zhao J,Guo D,Pang H,Zhao Y,Song J

    更新日期:2018-05-23 00:00:00

  • Regulation of vasoactive intestinal polypeptide release in the suprachiasmatic nucleus circadian clock.

    abstract::Timing of the mammalian circadian clock of the suprachiasmatic nucleus (SCN) is regulated by photic input from the retina. Retinorecipient units entrain rhythmicity of SCN pacemaker cells in part through their release of vasoactive intestinal polypeptide (VIP). The underlying nature of this process is conjectural, how...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e32833fcba4

    authors: Francl JM,Kaur G,Glass JD

    更新日期:2010-11-17 00:00:00

  • pH transients due to monosynaptic activation of GABAA receptors in rat hippocampal slices.

    abstract::Extracellular pH transients were evoked in rat hippocampal brain slices by activation of a monosynaptic inhibitory pathway following pharmacological blockade of glutaminergic transmission. Repetitive stimulation in stratum radiatum near the recording site in stratum pyramidale evoked an immediate alkaline shift which ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199201000-00028

    authors: Kaila K,Paalasmaa P,Taira T,Voipio J

    更新日期:1992-01-01 00:00:00

  • GABAergic tonic inhibition of substantia gelatinosa neurons in mouse spinal cord.

    abstract::We used whole-cell recording to identify, for the first time, GABAergic tonic current in subpopulations of substantia gelatinosa neurons in mouse spinal cord slices. Application of the gamma-aminobutyric acid type A receptor antagonist bicuculline revealed tonic currents in 49 of 73 substantia gelatinosa neurons. Thes...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/01.wnr.0000230515.86090.bc

    authors: Takahashi A,Mashimo T,Uchida I

    更新日期:2006-08-21 00:00:00

  • Sex differences in functional activation patterns revealed by increased emotion processing demands.

    abstract::Two [O(15)] PET studies assessed sex differences regional brain activation in the recognition of emotional stimuli. Study I revealed that the recognition of emotion in visual faces resulted in bilateral frontal activation in women, and unilateral right-sided activation in men. In study II, the complexity of the emotio...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200402090-00001

    authors: Hall GB,Witelson SF,Szechtman H,Nahmias C

    更新日期:2004-02-09 00:00:00

  • Gender impact on transcranial magnetic stimulation-based cortical excitability and cognition relationship in healthy individuals.

    abstract:OBJECTIVE:We sought to determine whether cortical excitability, measured via transcranial magnetic stimulation (TMS), is associated with cognition in healthy individuals and whether gender and education have an impact on this relationship. METHODS:Fifty-four healthy individuals (31 males, mean age = 41.94, SD = 21.98;...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000001392

    authors: Akilan K,Kumar S,Zomorrodi R,Blumberger DM,Daskalakis ZJ,Rajji TK

    更新日期:2020-03-04 00:00:00

  • The avian inferior olive derives from the alar neuroepithelium of the rhombomeres 7 and 8: an analysis by using chick-quail chimeric embryos.

    abstract::Homotopic and isochronic transplantation of the alar plate of the rhombomeres 7 and 8 was performed between chick and quail embryos at the stage of 10-14 somites. Analysis of the graft derivatives in 12-day-old chimeric embryos by means of the quail nucleolar marker showed that the ipsilateral inferior olive is formed...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199605170-00013

    authors: Ambrosiani J,Armengol JA,Martinez S,Puelles L

    更新日期:1996-05-17 00:00:00

  • Intestinal STC-1 cells respond to five basic taste stimuli.

    abstract::STC-1 cells have been established as an enteroendocrine cell line from the small intestine. By monitoring the level of intracellular Ca using a calcium-imaging technique, cellular responses of intestinal STC-1 cells to compounds of five basic tastants were investigated. Although this cell line was known to respond to ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e3282f242d3

    authors: Saitoh O,Hirano A,Nishimura Y

    更新日期:2007-12-03 00:00:00

  • Changes in transient receptor potential channels in the rat geniculate ganglion after chorda tympani nerve injury.

    abstract::We reported differential expression of the transient receptor potential vanilloid 1 (TRPV1), the transient receptor potential ankyrin 1 (TRPA1), and the (TRPM8) in the geniculate ganglions (GGs) of naive rats. In medical practice, the chorda tympani nerve (CTN) is injured in some patients during middle-ear surgery, an...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000000436

    authors: Tatsumi E,Katsura H,Kobayashi K,Yamanaka H,Tsuzuki K,Noguchi K,Sakagami M

    更新日期:2015-09-30 00:00:00

  • Induction of NG108-15 cells differentiation by human bone marrow stromal cells.

    abstract::The survival and differentiation of neuronal cells is dependent on factors such as neurotrophins, cytokines and components of extracellular matrix. Bone marrow stromal cells have been shown to support the growth and differentiation of neuroblastoma cells. In an attempt to study the effects of bone marrow stromal cells...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199805110-00021

    authors: Ho SH,So LH,Lai KO,Ip NY,Leung MF

    更新日期:1998-05-11 00:00:00

  • Ketamine differentially restores diverse alterations of neuroligins in brain regions in a rat model of neuropathic pain-induced depression.

    abstract::Depression is present in a large proportion of patients suffering from chronic pain, and yet the underlying mechanisms remain to be elucidated. Neuroligins (NLs), as a family of cell-adhesion proteins, are involved in synaptic formation and have been linked to various neuropsychiatric disorders. Here, we studied the a...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000001045

    authors: Pan W,Zhang GF,Li HH,Ji MH,Zhou ZQ,Li KY,Yang JJ

    更新日期:2018-07-04 00:00:00

  • Quadrupedal locomotor movements in monkeys (M. Fuscata) on a treadmill: kinematic analyses.

    abstract::Three adult Japanese monkeys (M. fuscata: body weights 4.5-8.5 kg) were trained to walk quadrupedally on a surface of a moving treadmill (walking length and width: 150 cm and 60 cm, treadmill speed: 0.4-1.7 m s-1. At any different constant treadmill velocity, the monkeys exhibited a diagonal pattern of locomotor movem...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199610020-00004

    authors: Mori S,Miyashita E,Nakajima K,Asanome M

    更新日期:1996-10-02 00:00:00

  • Corticotropin-releasing hormone 1 receptor antagonism attenuates chronic unpredictable mild stress-induced depressive-like behaviors in rats.

    abstract::Hyperactivity of the hypothalamic-pituitary-adrenal axis and impairment of the central corticotropin-releasing factor system are factors in the pathogenesis of depression. Though several antagonists of the corticotropin-releasing factor 1 receptor were effective in the recognized behavioral tests for antidepressant ac...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000001331

    authors: Wang XB,Zhang YQ,Xue RR,Yang ZZ,Zhang XF

    更新日期:2020-01-08 00:00:00

  • Prolonged changes in amyloid-β metabolism after a severe traumatic brain injury.

    abstract::Traumatic brain injury (TBI) is a major risk factor for Alzheimer's disease. Recent studies suggest that amyloid-beta (Aβ) deposit can be detected several years after TBI. However, it is unknown whether post-TBI Aβ deposits arise from short-term changes in Aβ metabolism or reflect a long-term sequela. To answer this q...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000000748

    authors: Bagnato S,Andriolo M,Boccagni C,Galardi G

    更新日期:2017-03-22 00:00:00

  • Melatonin inhibits oxytocin and vasopressin release from the neurointermediate lobe of the hamster pituitary.

    abstract::The aim of this investigation was to study whether melatonin affects the release of oxytocin and vasopressin by the pituitary neurointermediate lobe of the Syrian hamster in vitro. The effect of melatonin was studied on the unstimulated (pre- and post-K+ -stimulated) release of oxytocin and vasopressin and on the resp...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199512150-00004

    authors: Juszczak M,Debeljuk L,Bartke A,Stempniak B

    更新日期:1995-12-15 00:00:00

  • Neuroserpin is expressed in early stage of neurogenesis in adult rat hippocampus.

    abstract::In the adult rat hippocampal formation, neurogenesis occurs in the dentate gyrus subgranular zone (SGZ). We used laser capture microdissection and an antidepressant-related genes microarray to analyze gene expression profiles of cells from the SGZ and from the outermost granule cell layer. Of the differentially expres...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e3283350b24

    authors: Yamada M,Takahashi K,Ukai W,Hashimoto E,Saito T,Yamada M

    更新日期:2010-01-27 00:00:00

  • Is there a link between sleep changes and memory in Alzheimer's disease?

    abstract::Aging and Alzheimer's disease (AD) are both characterized by memory impairments and sleep changes. We investigated the potential link between these disturbances, focusing on sleep spindles, involved in memory consolidation. Two episodic memory tasks were given to young and old healthy participants, as well as to AD pa...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e32830867c4

    authors: Rauchs G,Schabus M,Parapatics S,Bertran F,Clochon P,Hot P,Denise P,Desgranges B,Eustache F,Gruber G,Anderer P

    更新日期:2008-07-16 00:00:00

  • N400 responses of children with primary language disorder: intervention effects.

    abstract::Event-related brain potentials were examined in 6 to 8-year-old children with primary language disorder before and after a 5-week narrative-based language intervention. Participants listened to sentences ending with semantically congruous or incongruous words. By comparison with typical controls, the children with pri...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e32832e9c97

    authors: Popescu M,Fey ME,Lewine JD,Finestack LH,Popescu EA

    更新日期:2009-08-05 00:00:00

  • Schwann cells induce neuronal differentiation of bone marrow stromal cells.

    abstract::Bone marrow stromal cells are multipotent stem cells that have the potential to differentiate into bone, cartilage, fat and muscle. Recently, bone marrow stromal cells have been shown to have the capacity to differentiate into neurons under specific experimental conditions, using chemical factors. We now describe how ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200504040-00017

    authors: Zurita M,Vaquero J,Oya S,Miguel M

    更新日期:2005-04-04 00:00:00

  • Long distance pathways of diffusion for dextran along fibre bundles in brain. Relevance for volume transmission.

    abstract::Texas Red-labelled dextran with a mol. wt of 3000 g mol-1, a marker for the extracellular space, was injected unilaterally into the neostriatum of adult rats (0.3-30 micrograms microliter-1) and its distribution evaluated 1 min to 5 h later. Diffusion in the neuropil was observed with clearance starting after 30 min. ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199505090-00014

    authors: Bjelke B,England R,Nicholson C,Rice ME,Lindberg J,Zoli M,Agnati LF,Fuxe K

    更新日期:1995-05-09 00:00:00

  • Ulcerogenic cinchophen induces c-Fos expression in CRH-secreting cells in the PVH of rat brain.

    abstract::This study aimed at obtaining evidence that cinchophen, an ulcerogenic drug, stimulates the corticotropin-releasing hormone (CRH)-secreting cells in the paraventricular nucleus of the hypothalamus (PVH) to induce c-Fos expression. Without colchicine pretreatment, cinchophen was injected i.p. 60 min before the time of ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199611040-00048

    authors: Jingu H,Miura M

    更新日期:1996-11-04 00:00:00

  • Self-face recognition in attended and unattended conditions: an event-related brain potential study.

    abstract::This study investigated whether neural mechanisms of self-face recognition are modulated by attention by recording event-related brain potentials associated with self-face recognition. Participants identified head orientations of self-faces and familiar or unfamiliar other faces presented briefly at the center of the ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/01.wnr.0000203357.65190.61

    authors: Sui J,Zhu Y,Han S

    更新日期:2006-03-20 00:00:00