Abstract:
:Texas Red-labelled dextran with a mol. wt of 3000 g mol-1, a marker for the extracellular space, was injected unilaterally into the neostriatum of adult rats (0.3-30 micrograms microliter-1) and its distribution evaluated 1 min to 5 h later. Diffusion in the neuropil was observed with clearance starting after 30 min. After 10-15 min strong labelling along the myelinated fibre bundles was observed in the entire neostriatum. After about 20 min the labelling along the fibres reached into the corpus callosum and the overlaying deep layers of the cerebral cortex. A marked cellular uptake and accumulation of labelled dextran was found in putative perivascular pericytes. Thus, in the living brain preferential extracellular fluid pathways for diffusion exist, especially along fibre bundles, which allow the exchange of chemical signals between two distant regions. These may represent extracellular fluid pathways for volume transmission.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Bjelke B,England R,Nicholson C,Rice ME,Lindberg J,Zoli M,Agnati LF,Fuxe Kdoi
10.1097/00001756-199505090-00014subject
Has Abstractpub_date
1995-05-09 00:00:00pages
1005-9issue
7eissn
0959-4965issn
1473-558Xjournal_volume
6pub_type
杂志文章相关文献
NEUROREPORT文献大全abstract::Prior research with rodent models, performed predominantly in males, has demonstrated a significant association between focal neocortical malformations (e.g. ectopias and microgyria) and rate-specific auditory processing deficits. In the current study and consistent with prior findings, we report that ectopic male BXS...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200212030-00021
更新日期:2002-12-03 00:00:00
abstract::Approximately 30% of patients with fatal head injuries have deposits of amyloid beta-protein (A beta); these are predominantly individuals carrying the epsilon 4 allele of apolipoprotein E (apoE). A beta deposition occurs in Alzheimer's disease (AD), for which approximately 50% of the genetic risk is attributed to apo...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199612200-00010
更新日期:1996-12-20 00:00:00
abstract::Echo-Planar functional magnetic resonance imaging (EP-fMRI) was used to study the activity of the amygdala while three normal female subjects viewed alternating blocks of affectively neutral and affectively negative still pictures. Bilateral activation in the amygdala that was significantly correlated with the changin...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199607290-00014
更新日期:1996-07-29 00:00:00
abstract::As treatment of ischemic stroke remains a challenge with respect to the failure of numerous neuroprotective attempts, there is an ongoing need for better understanding of pathophysiological mechanisms causing tissue damage. Although ischemic outcomes have been studied extensively at the cellular and molecular level us...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000395
更新日期:2015-07-08 00:00:00
abstract::Unilateral neglect has been recently shown to be improved following a short period of adaptation to wedge prisms. The present study investigates whether visuo-motor adaptation can generate a bias in normals on line bisection tasks classically used to assess unilateral neglect. Our results show that adaptation to left-...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200006260-00019
更新日期:2000-06-26 00:00:00
abstract::Electrophysiological studies have shown that somatostatin (SOM; 10(-8) and 10(-7) M) causes a hyperpolarization of the majority of astrocytes in explant cultures of rat spinal cord and cortex. When SOM and the cholinergic agonists muscarine and nicotine (10(-6) M) were tested on the same cell, all three compounds prod...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199407000-00015
更新日期:1994-07-21 00:00:00
abstract::The whole-cell patch-clamp technique was employed to investigate the development of voltage-gated currents in cultured newt retinal pigment epithelial (RPE) cells. Freshly dissociated RPE cells were inexcitable and mainly exhibited a voltage-gated outward K+ current. Within a few days in culture RPE cells began to fla...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199404000-00020
更新日期:1994-04-14 00:00:00
abstract::The tetrodotoxin-resistant voltage-gated sodium channel Nav 1.8 is expressed only in nociceptive sensory neurons. This channel has been proposed to contribute significantly to the sensitization of primary sensory neurons after injury. We have studied the nociceptive behaviours of mice carrying a null mutation in the N...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200110080-00019
更新日期:2001-10-08 00:00:00
abstract::Cortical auditory categorization was assessed in 2-month-old infants at genetic risk for dyslexia and controls. Manipulated /bAk/ and /dAk/ speech stimuli were used as frequently presented standards. The neuroelectric brain responses of the control infants were highly sensitive to the phoneme boundary that separated t...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3280c1e2bf
更新日期:2007-06-11 00:00:00
abstract::Some of the most extensively used fluorophores for multicolour fluorescence labelling of tissue, such as Lucifer yellow, fluorescein, Cyanine-3.18 and rhodamine, all have the disadvantage of being difficult to separate spectrally due to their broad and overlapping emission spectra. With the intensity-modulated multipl...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199505300-00024
更新日期:1995-05-30 00:00:00
abstract::We investigated the mRNA levels of neuronal, inducible, endothelial nitric oxide synthases (nNOS, iNOS, eNOS) and tumor necrosis factor-alpha (TNF-alpha) in a rat dorsal root ganglion (DRG) after tourniquet application to a hind limb to identify molecules that trigger secondary events after peripheral nerve injury. Si...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200312020-00026
更新日期:2003-12-02 00:00:00
abstract::Psychotic-like episodes in divers exposed to high pressure have been attributed to either the high-pressure neurological syndrome, confinement in pressure chamber, the subject's personality, or the addition of nitrogen or hydrogen to the basic helium-oxygen breathing mixture used for deep diving. Alternatively, it is ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199503000-00027
更新日期:1995-03-07 00:00:00
abstract::We have investigated the hypothesis that the acute ischemic swelling of the radial dendrites connected to the inner hair cells (IHCs) is mediated by glutamatergic receptors. In control cochleas, after 20 min ischemia all the dendrites were dramatically swollen. Conversely, after a perfusion of 50 microM 6-7-dinitroqui...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199204000-00002
更新日期:1992-04-01 00:00:00
abstract::Immunohistochemistry was used to demonstrate urotensin I (UI), urotensin II (UII), and angiotensinogen (Ao)-like immunoreactivities (ir) in the CNS of Aplysia californica. The fish UI is a 41 amino acid peptide that has 50% identity with mammalian corticotropin-releasing factor (CRF). Identity also exists between UI a...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199502000-00033
更新日期:1995-02-15 00:00:00
abstract::AMPA-preferring glutamate receptor genes gluR1-4 undergo alternative splicing into flip and flop mRNA isoforms. In the rodent hippocampus, gluR1 and gluR2 isoforms are differentially expressed. We have studied their distribution in human hippocampus. As in the rat, flop isoforms predominate over flip in dentate gyrus,...
journal_title:Neuroreport
pub_type: 杂志文章
doi:
更新日期:1994-06-27 00:00:00
abstract::Microglial activation is thought to contribute to the progression of selective motor neuron death during amyotrophic lateral sclerosis (ALS). As minocycline has been shown to inhibit microglial activation, the therapeutic efficacy of this tetracycline derivative in the G93A mice model for familial ALS was tested. This...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200206120-00018
更新日期:2002-06-12 00:00:00
abstract::Bilabial, alveolar and velar sounds are produced at different locations around the oral cavity. fMRI was used to localize cortical representation of articulation in seven healthy subjects during repetitive lip and vertical tongue movements as well as repetitive articulation of /pa/ (bilabial), /ta/ (alveolar), /ka/ (v...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200009110-00032
更新日期:2000-09-11 00:00:00
abstract::Effects of glutamate on synaptic transmission in the submucosal plexus of guinea-pig small intestine were studied with intracellular electrophysiological recording methods. Glutamate suppressed stimulus-evoked slow excitatory postsynaptic potentials (EPSPs) and increased the amplitude of slow inhibitory postsynaptic p...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199909290-00031
更新日期:1999-09-29 00:00:00
abstract::Epilepsy is a neurological disorder with recurrent unprovoked seizures as the main symptom. Of the coumarin derivatives in Angelica gigas, decursin, a major coumarin component, was reported to exhibit significant protective activity against glutamate-induced neurotoxicity when added to primary cultures of rat cortical...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000208
更新日期:2014-11-12 00:00:00
abstract::The autoradiographic distribution of Ca(2+)-sensitive high- and low-affinity binding sites for the N-type calcium channel ligand, [125I]omega-conotoxin GVIA, has been examined in rat brain. Both classes of sites were rather evenly distributed, exhibiting their highest density in cell body rich layers, such as the pyra...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199405000-00025
更新日期:1994-05-09 00:00:00
abstract::Changes in nitric oxide (NO) concentration and cerebral blood flow (CBF) in the parietal cortex during hypercapnoea were investigated in anaesthetized rats, using a NO-selective electrode and laser Doppler flowmetry. When hypercapnoea was induced by inhalation of 5% CO2 for 10 min, both the NO concentration and CBF in...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199703030-00036
更新日期:1997-03-03 00:00:00
abstract::The primate pulvinar connects with the entire array of known visual areas and is postulated to play a role in selective visual attention. Recently, five separate neurochemical subdivisions of a region termed the inferior pulvinar (PI) complex were identified in monkeys. In the present study, similar histochemical proc...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199912160-00002
更新日期:1999-12-16 00:00:00
abstract::Target detection is the process of bringing a salient stimulus into conscious awareness. Target detection evokes a prominent event-related potential (ERP) component (P3) in the electroencephalogram (EEG). We combined the high spatial resolution of functional magnetic resonance imaging (fMRI) with the high temporal res...
journal_title:Neuroreport
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00001756-199709290-00007
更新日期:1997-09-29 00:00:00
abstract::Deficits in processing of auditory stimuli are known to play an important role in the aetiology of dyslexia. To specify the auditory deficit in children at risk for dyslexia, 19 children with a phonological deficit and 15 controls were tested using the mismatch negativity event-related potential, which reflects preatt...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32810f2e25
更新日期:2007-06-11 00:00:00
abstract::This study investigated whether mild birth complications (C-section birth, C-section + 15 min global anoxia) interact with stress at adulthood to modulate levels of [3H]WIN 35428 binding to dopamine transporters (DAT) in rat brain. Without stress, adult C-sectioned rats showed increased DAT binding in the dorsal stria...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200202110-00006
更新日期:2002-02-11 00:00:00
abstract::We investigated the detection of rare task-irrelevant changes in the lexical status of speech stimuli. Participants performed a nonlinguistic task on word and pseudoword stimuli that occurred, in separate conditions, rarely or frequently. Task performance for pseudowords was deteriorated relative to words, suggesting ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3282f0ea16
更新日期:2007-10-29 00:00:00
abstract::Whereas in the mature retina the glutamate agonist 2-amino-4-phosphonobutyric acid (APB) selectively activates currents in rod bipolar and ON-cone bipolar cells, recent molecular studies have suggested the possibility of a transient appearance of the APB-sensitive receptor in developing retinal ganglion cells. In the ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199611250-00013
更新日期:1996-11-25 00:00:00
abstract::24S-hydroxycholesterol, the primary oxidation product of cholesterol in the brain, plays a key role in cholesterol elimination and homeostasis. While the concentration of this neurotoxic oxysterol decreases with age, 24S-hydroxycholesterol is elevated in Alzheimer's disease. In this study, we examined the effects of 2...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200506210-00007
更新日期:2005-06-21 00:00:00
abstract::When we perform a visually guided reaching action, the brain coordinates our hand and eye movements. Eye-hand coordination has been examined widely, but it remains unclear whether the hand and eye motor systems are coordinated during on-line visuomotor adjustments induced by a target jump during a reaching movement. A...
journal_title:Neuroreport
pub_type: 杂志文章,随机对照试验
doi:10.1097/WNR.0000000000000111
更新日期:2014-05-07 00:00:00
abstract::Although citral, which is abundantly present in lemongrass, has various actions including antinociception, how citral affects synaptic transmission has not been examined as yet. Citral activates in heterologous cells transient receptor potential vanilloid-1, ankyrin-1, and melastatin-8 (TRPV1, TRPA1, and TRPM8, respec...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000518
更新日期:2016-02-10 00:00:00