Abstract:
:We investigated the mRNA levels of neuronal, inducible, endothelial nitric oxide synthases (nNOS, iNOS, eNOS) and tumor necrosis factor-alpha (TNF-alpha) in a rat dorsal root ganglion (DRG) after tourniquet application to a hind limb to identify molecules that trigger secondary events after peripheral nerve injury. Significantly high nNOS, iNOS mRNA and protein levels were observed in the ipsilateral DRGs 4 h after tourniquet application but not in the contralateral or control DRGs. The levels of TNF-alpha, an inducer of iNOS, were significantly increased in the ipsilateral DRGs 1 h after tourniquet application. Large amounts of NO might result in damage to the host cells and induce apotosis to eliminate damaged cells during the early stage of nerve injury.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Abe S,Mizusawa I,Kanno K,Yabashi A,Suto M,Kuraya M,Honda T,Hiraiwa Kdoi
10.1097/00001756-200312020-00026subject
Has Abstractpub_date
2003-12-02 00:00:00pages
2267-70issue
17eissn
0959-4965issn
1473-558Xjournal_volume
14pub_type
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