Abstract:
:We have isolated a cDNA encoding an inwardly rectifying K+ channel (HH-IRK1) from human heart. The cDNA codes for a 427-amino acid protein, with two putative transmembrane domains and an H5 region. The primary structure of HH-IRK1 is homologous to that of the IRK1 channel cloned from a mouse macrophage-like cell line. Functional expression in Xenopus oocytes showed that HH-IRK1 is a K+ channel with strong inward rectification, blocked by extracellular Ba2+ and Cs+, and with a single-channel conductance of 30 pS. Northern analysis showed HH-IRK1 transcripts in human heart, brain, skeletal muscle, placenta, lung and kidney. HH-IRK1 was mapped to human chromosome 17.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Raab-Graham KF,Radeke CM,Vandenberg CAdoi
10.1097/00001756-199412000-00024subject
Has Abstractpub_date
1994-12-20 00:00:00pages
2501-5issue
18eissn
0959-4965issn
1473-558Xjournal_volume
5pub_type
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