Gene expression in the geniculate induced by a nonphotic circadian phase shifting stimulus.

Abstract:

:We examined the effect of a nonphotic stimulus (running in a novel wheel) on the induction of Fos-related proteins in the two well-established neural components of the circadian clock: the suprachiasmatic nucleus (SCN) and the intergeniculate leaflet (IGL) of the lateral geniculate complex. There was no induction of Fos immunoreactivity (IR) in the SCN, but the IGL showed distinct Fos IR in animals whose running levels were associated with maximal rhythm shifts. Induction of Fos immunoreactivity was greatest at circadian phases when wheel running induces phase shifts. This temporal and spatial specificity of Fos induction is evidence that the intergeniculate leaflet mediates nonphotic signals to the circadian clock.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Janik D,Mrosovsky N

doi

10.1097/00001756-199207000-00007

subject

Has Abstract

pub_date

1992-07-01 00:00:00

pages

575-8

issue

7

eissn

0959-4965

issn

1473-558X

journal_volume

3

pub_type

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