Membrane fatty acid composition shows delta-6-desaturase abnormalities in Alzheimer's disease.

abstract：:Recently, it has been shown that visual perception can be radically altered by signals of other modalities. For example, when a single flash is accompanied by multiple auditory beeps, it is often perceived as multiple flashes. This effect is known as the sound-induced flash illusion. In order to investigate the princi...

journal_title：Neuroreport

authors： Shams L,Ma WJ,Beierholm U

更新日期：2005-11-28 00:00:00

abstract：:During the development of central nervous system, radial glial cells support target-specific neuronal migration. We recently reported that after implantation of chitosan channels with complete spinal cord transection, the tissue bridging the spinal cord stumps contained axons and radial glial cells. The purpose of thi...

journal_title：Neuroreport

authors： Nomura H,Kim H,Mothe A,Zahir T,Kulbatski I,Morshead CM,Shoichet MS,Tator CH

更新日期：2010-09-15 00:00:00

abstract：:α-Gustducin (Gα-gust) is the α subunit of the heterotrimeric G-protein complex specific for taste receptor cells of the tongue. However, it has been shown to be present in ectopic regions, such as airways and digestive tract. Recently, Gα-gust was found within neurons in various regions of the mouse brain. In this stu...

journal_title：Neuroreport

authors： Son MJ,Hu YJ,Kim SA,Chun MH,Kim IB,Kim MS

更新日期：2011-02-16 00:00:00

abstract：:This study was carried out based on the assumption that brain-derived neurotrophic factor (BDNF) may counterbalance the action of morphine in the brain. Morphine analgesic tolerance after daily administrations for six days was blocked by intracerebroventricular injection of anti-BDNF IgG on day 5, but not by administr...

journal_title：Neuroreport

authors： Matsushita Y,Ueda H

更新日期：2009-01-07 00:00:00

abstract：:Electrophysiological studies have shown that somatostatin (SOM; 10(-8) and 10(-7) M) causes a hyperpolarization of the majority of astrocytes in explant cultures of rat spinal cord and cortex. When SOM and the cholinergic agonists muscarine and nicotine (10(-6) M) were tested on the same cell, all three compounds prod...

journal_title：Neuroreport

authors： Hösli L,Hösli E,Winter T,Stauffer S

更新日期：1994-07-21 00:00:00

abstract：:We constructed two replication-deficient recombinant adenovirus vectors coding human basic fibroblast growth factor (bFGF), one with and one without the interleukin-2 (IL-2) secretory signal sequence and examined their neurotrophic effects on primary neuronal cells in vitro. The primary neuronal cells were successfull...

journal_title：Neuroreport

authors： Matsuoka N,Miyatake S,Yukawa H,Takahashi JC,Saiki M,Mori H,Ishii K,Akimoto M,Hamada H,Hashimoto N

更新日期：2000-06-26 00:00:00

abstract：:Frontolimbic structures involved in fear conditioning have also been associated with hypothalamic-pituitary-adrenal (HPA)-axis modulation, including amygdaloid, hippocampal, and ventromedial prefrontal cortex regions. Although HPA-axis function and endocrine changes have been investigated in the context of stress prov...

journal_title：Neuroreport

authors： Root JC,Tuescher O,Cunningham-Bussel A,Pan H,Epstein J,Altemus M,Cloitre M,Goldstein M,Silverman M,Furman D,Ledoux J,McEwen B,Stern E,Silbersweig D

更新日期：2009-03-04 00:00:00

abstract：:In previous studies, we demonstrated functional neuronal and dopaminergic differentiation of fetal mesencephalic neural precursor cells. The major factors for orienting their progeny towards a dopaminergic phenotype are forskolin and interleukin-1beta. Here, we investigated the effects of dexamethasone (10 microM) on ...

journal_title：Neuroreport

authors： Sabolek M,Herborg A,Schwarz J,Storch A

更新日期：2006-11-06 00:00:00

abstract：:In order to clarify whether neurophysiological profiles affect the performance of brain machine interfaces (BMI), we examined the relationships between amplitudes of movement-related cortical fields (MRCFs) and decoding performances during movement. Neuromagnetic activities were recorded in nine healthy participants d...

journal_title：Neuroreport

authors： Sugata H,Goto T,Hirata M,Yanagisawa T,Shayne M,Matsushita K,Yoshimine T,Yorifuji S

更新日期：2012-01-04 00:00:00

abstract：:To detect stress responses of the brain to subarachnoid hemorrhage (SAH), we investigated the expression of immediate early genes (IEGs) and hsp70 mRNA by in situ hybridization. Experimental SAH was produced in 49 rats by endovascular penetration. We also monitored the intracranial pressure (ICP) changes. The genes c-...

journal_title：Neuroreport

authors： Harada S,Kamiya K,Masago A,Iwata A,Yamada K

更新日期：1997-10-20 00:00:00

abstract：:We investigated the roles of the auditory cortex in discrimination learning of vowel-like sounds consisting of multiple formants. Rats were trained to discriminate between synthetic sounds with four formants. Bilateral electrolytic lesions including the primary auditory cortex and the dorsal auditory association corte...

journal_title：Neuroreport

authors： Kudoh M,Nakayama Y,Hishida R,Shibuki K

更新日期：2006-11-27 00:00:00

abstract：:With the purpose of mapping representations of the finger and proximal arm in the human primary motor cortex (MI), we measured regional cerebral blood flow (rCBF) in eight right-handed normal volunteers during self-paced finger and proximal arm movements. Each movement activated two different fields in MI, one located...

journal_title：Neuroreport

authors： Kawashima R,Itoh H,Ono S,Satoh K,Furumoto S,Gotoh R,Koyama M,Yoshioka S,Takahashi T,Yanagisawa T

更新日期：1995-01-26 00:00:00

abstract：:It has been reported that intracerebroventricular (i.c.v.) injection of nociception/orphanin FQ (OFQ) can antagonize morphine analgesia, whereas i.c.v. OFQ antibody can reverse morphine tolerance. Nocistatin (NST) is a recently characterized neuropeptide possessing an antagonizing effect on OFQ. Here we examine whethe...

journal_title：Neuroreport

authors： Sun RQ,Zhao CS,Wang HJ,Jing Z,Wang W,Yang K,Wang Y,Chang JK,Han JS

更新日期：2001-06-13 00:00:00

abstract：:Increased oxidative stress in the brain due to chronic ethanol consumption is known to result in a number of neurodegenerative changes. This study was designed to test whether dietary supplementation of grape polyphenols (GP) can offer protection to the neurodegenerative changes resulting from chronic ethanol consumpt...

journal_title：Neuroreport

authors： Sun GY,Xia J,Draczynska-Lusiak B,Simonyi A,Sun AY

更新日期：1999-01-18 00:00:00

abstract：:Changes in the regulation, formation, and gating of connexin-based gap junction channels occur in various disorders. It has been shown that H and Ca are involved in the regulation of gap junctional communication. Ischemia-induced intracellular acidification and Ca overload lead to closure of gap junctions and inhibit ...

journal_title：Neuroreport

authors： Kucheryavykh LY,Benedikt J,Cubano LA,Skatchkov SN,Bukauskas FF,Kucheryavykh YV

更新日期：2017-03-01 00:00:00

abstract：:Factors controlling proliferation and differentiation are crucial in advancement of neural cell-based experimental neurodegenerative therapies. In this regard, nicotinamide has been shown to determine the fate of neural cells, enhance neuralization, and influence DNA repair and apoptosis. This study investigated wheth...

journal_title：Neuroreport

authors： Griffin SM,Pickard MR,Orme RP,Hawkins CP,Fricker RA

更新日期：2013-12-18 00:00:00

abstract：:We investigated the mode of action of argiotoxin636 on isolated N-methyl-D-aspartate (NMDA) receptor channels in cultured cerebellar granule cells. We found that the toxin blocks NMDA channels by decreasing their opening probability and by inducing a flickering activity, in a voltage-dependent manner. Our results indi...

journal_title：Neuroreport

authors： Fagni L,Bockaert J

更新日期：1995-05-09 00:00:00

abstract：:Hair cells in the frog semicircular canal, studied by the whole-cell patch-clamp technique, display three distinct Ca2+ currents: two non-inactivating components (L type and R type, the latter termed R2 in the following) and a second R type current (termed R1), which runs down first and inactivates in a Ca2+-dependent...

journal_title：Neuroreport

authors： Rispoli G,Martini M,Rossi ML,Rubbini G,Fesce R

更新日期：2000-08-21 00:00:00

abstract：:Correcting for eddy currents, movement-induced distortion and gradient inhomogeneities is imperative when processing diffusion MRI (dMRI) data, but is highly computing resource-intensive. Recently, Compute Unified Device Architecture (CUDA) was implemented for the widely-used eddy-correction software, 'eddy', which re...

journal_title：Neuroreport

authors： Maller JJ,Grieve SM,Vogrin SJ,Welton T

更新日期：2020-07-10 00:00:00

abstract：:In this study, an algorithm is introduced for the automatic detection and simultaneous topographic classification of interictal regional spike activity in pediatric surface EEG records. The algorithm is based on the classification of the topographic distribution of instantaneous power by means of a 'group' trained cla...

journal_title：Neuroreport

authors： Feucht M,Hoffmann K,Steinberger K,Witte H,Benninger F,Arnold M,Doering A

更新日期：1997-07-07 00:00:00

abstract：:The gene expression of cholecystokinin (CCK), a neuropeptide with anti-opioid properties, has been reported to be upregulated in some primary sensory neurons after a peripheral nerve lesion. We have recently demonstrated that the upregulation of CCK mRNA is not accompanied by an increased potassium-evoked release CCK-...

journal_title：Neuroreport

authors： Afrah AW,Gustafsson H,Olgart L,Brodin E,Stiller CO

更新日期：2001-01-22 00:00:00

abstract：:Papaverine is a non-specific vasodilatory drug, which was found to unexpectedly cause opening of the blood-brain barrier (BBB). We studied the expression of two endothelial cell related markers, endothelial barrier antigen (EBA) as a marker of BBB intactness, and matrix metalloproteinase-9 (MMP-9), an extracellular ma...

journal_title：Neuroreport

authors： Bhattacharjee AK,Kondoh T,Ikeda M,Kohmura E

更新日期：2002-12-03 00:00:00

abstract：:The whole cell configuration of the patch clamp technique was used to study the biophysical and pharmacological properties of voltage activated Ca2+ channel currents on hippocampal neurones cultured in the presence or absence of foetal calf serum. In the presence of serum cells were intensively immunostained with neur...

journal_title：Neuroreport

authors： Bertollini L,Cattaneo A,Cherubini E

更新日期：1995-04-19 00:00:00

abstract：:The aim of this study was to identify age-related changes of P300 peak amplitude and P300 latency between closely separated nonsenile age groups (late young-aged adults and early middle-aged adults) and to investigate whether or not P300 has the potential to be used as a measure of cognitive aging even among nonsenile...

journal_title：Neuroreport

authors： Bourisly AK

更新日期：2016-09-28 00:00:00

abstract：:Brief tetanic stimulation of parallel fibres can evoke a slow excitatory postsynaptic potential (EPSP) in cerebellar Purkinje cells that is mediated by metabotropic glutamate receptors (mGluRs). It is likely that the receptor subtype involved is mGluR1, which couples to the production of diacylglycerol and inositol-1,...

journal_title：Neuroreport

authors： Batchelor AM,Vranesic I,Del Principe F,Garthwaite J,Knöpfel T

更新日期：1996-08-12 00:00:00

abstract：:Multiple sclerosis is associated with reduced white matter integrity and deficits in key cognitive processes important for arithmetic. This study examined the relationship between white matter microstructure and academic ability in 31 youths with multiple sclerosis (aged 11-19 years) and 34 demographically matched con...

journal_title：Neuroreport

authors： Till C,Deotto A,Tipu V,Sled JG,Bethune A,Narayanan S,Arnold DL,Banwell BL

更新日期：2011-12-21 00:00:00

abstract：:The effects of a pharmacological blockade of the periaqueductal grey of the midbrain (PAG) on the elicitability of vocal fold movements from the facial motor cortex on the one hand and the anterior cingulate cortex and dorsomedial hypothalamus on the other were studied in the squirrel monkey. PAG blockade abolished vo...

journal_title：Neuroreport

authors： Jürgens U,Zwirner P

更新日期：1996-11-25 00:00:00

abstract：:Fragile X syndrome is a neurodevelopmental disorder caused by a trinucleotide (CGG) hyperexpansion in the FMR1 gene, functionally silencing transcription of the fragile X mental retardation protein (FMRP). This disorder is characterized by impaired cognition, communication, and social behavior. The aim of this study w...

journal_title：Neuroreport

authors： Reynolds CD,Nolan SO,Jefferson T,Lugo JN

更新日期：2016-12-14 00:00:00

abstract：:Altered glutamate signaling is associated with Parkinson's disease. To study the involvement of the cystine/glutamate antiporter in the pathogenesis of Parkinson's disease, we developed new polyclonal antibodies recognizing xCT, the specific subunit of this antiporter. The striatal xCT protein expression level was inv...

journal_title：Neuroreport

authors： Massie A,Schallier A,Mertens B,Vermoesen K,Bannai S,Sato H,Smolders I,Michotte Y

更新日期：2008-10-29 00:00:00

abstract：:The discovery of mis-sense mutations linking the presenilin-1 (PS-1) gene on chromosome 14 to Alzheimer's disease (AD) has lead to a thorough investigation of this locus. The PS-1 gene contains a polymorphism creating two alleles. The most common allele, allele 1, has been linked with late-onset AD. Given the clinical...

journal_title：Neuroreport

authors： Singleton AB,Lamb H,Leake A,McKeith IG,Ince PG,Perry RH,Morris CM

更新日期：1997-11-10 00:00:00