Abstract:
:Frontolimbic structures involved in fear conditioning have also been associated with hypothalamic-pituitary-adrenal (HPA)-axis modulation, including amygdaloid, hippocampal, and ventromedial prefrontal cortex regions. Although HPA-axis function and endocrine changes have been investigated in the context of stress provocation, much research has not been conducted using functional neuroimaging in the study of the HPA axis and frontolimbic function in response to emotional stimuli. Using functional magnetic resonance imaging, the association of blood-oxygen-level dependent signal with salivary cortisol in response to an emotional visual scene paradigm was investigated, with prescan and postscan salivary cortisol analyzed as a covariate of interest during specific conditions. Cortisol reactivity to the paradigm was positively associated with amygdalar and hippocampal activity and negatively associated with ventromedial prefrontal cortex activity in conditions involving emotional imagery.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Root JC,Tuescher O,Cunningham-Bussel A,Pan H,Epstein J,Altemus M,Cloitre M,Goldstein M,Silverman M,Furman D,Ledoux J,McEwen B,Stern E,Silbersweig Ddoi
10.1097/WNR.0b013e328326a031subject
Has Abstractpub_date
2009-03-04 00:00:00pages
429-34issue
4eissn
0959-4965issn
1473-558Xjournal_volume
20pub_type
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