Abstract:
:We studied the neural substrate of anticipation and learning of smooth pursuit eye movements in humans using fMRI. Both predictable and non-predictable eye movements, compared to baseline, activated a common network previously associated with oculomotor function. The temporal dynamics of activity in a subset of these areas suggested a strong correlation with type of condition. Specifically, differential decreases in activity were seen in dorsolateral prefrontal cortex and the intraparietal sulcus during the predictable condition. During the non-predictable condition the same areas exhibited evidence of high levels of activity that further increased throughout the condition. In contrast, differential increases associated with the predictable condition were seen in anterior cingulate and preSMA cortex regions. These changes in activity mirror the time course of the short-term learning of eye movements seen behaviourally, and are congruent with learning-related changes that have been reported for other motor paradigms.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Schmid A,Rees G,Frith C,Barnes Gdoi
10.1097/00001756-200105250-00023subject
Has Abstractpub_date
2001-05-25 00:00:00pages
1409-14issue
7eissn
0959-4965issn
1473-558Xjournal_volume
12pub_type
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