Central effect of melatonin against stress-induced gastric ulcers in rats.

Abstract:

:We investigated the role of melatonin in the induction of gastric lesions induced by water immersion restraint stress or centrally administered thyrotropin-releasing hormone (TRH). Melatonin (0.1-1 ng) injected intracisternally (i.c) 30 min prior to stress dose-dependently inhibited the induction of gastric lesions by water immersion restraint stress, while 100 micrograms/kg, i.p. failed to protect the gastric mucosa. Preadministration of melatonin (1 ng, i.c.) significantly reduced (83%) the severity of gastric lesions induced by a TRH analogue (500 ng, i.c.). Serum melatonin concentrations 30 min after administration of 1 ng melatonin i.c. did not differ from those of rats receiving i.c. vehicle. These results suggest that melatonin plays a protective, anti-stress, role in the gastric mucosa via a mechanism involving the central nervous system.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Kato K,Murai I,Asai S,Komuro S,Matsuno Y,Matsukawa Y,Kurosaka H,Iwasaki A,Ishikawa K,Arakawa Y

doi

10.1097/00001756-199707070-00041

subject

Has Abstract

pub_date

1997-07-07 00:00:00

pages

2305-9

issue

9-10

eissn

0959-4965

issn

1473-558X

journal_volume

8

pub_type

杂志文章
  • The activation of metabotropic glutamate 5 receptors in the rat ventral tegmental area increases dopamine extracellular levels.

    abstract::The mesocorticolimbic circuit projects to the prefrontal cortex, hippocampus, amygdala, and nucleus accumbens, among others, and it originates in the dopaminergic neurons of the ventral tegmental area (VTA). The VTA receives glutamatergic inputs from the prefrontal cortex and several subcortical regions. The glutamate...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000000708

    authors: Ferrada C,Sotomayor-Zárate R,Abarca J,Gysling K

    更新日期:2017-01-01 00:00:00

  • Evidence for inert gas narcosis mechanisms in the occurrence of psychotic-like episodes at pressure environment.

    abstract::Psychotic-like episodes in divers exposed to high pressure have been attributed to either the high-pressure neurological syndrome, confinement in pressure chamber, the subject's personality, or the addition of nitrogen or hydrogen to the basic helium-oxygen breathing mixture used for deep diving. Alternatively, it is ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199503000-00027

    authors: Abraini JH

    更新日期:1995-03-07 00:00:00

  • MMP-9 and EBA immunoreactivity after papaverine mediated opening of the blood-brain barrier.

    abstract::Papaverine is a non-specific vasodilatory drug, which was found to unexpectedly cause opening of the blood-brain barrier (BBB). We studied the expression of two endothelial cell related markers, endothelial barrier antigen (EBA) as a marker of BBB intactness, and matrix metalloproteinase-9 (MMP-9), an extracellular ma...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200212030-00011

    authors: Bhattacharjee AK,Kondoh T,Ikeda M,Kohmura E

    更新日期:2002-12-03 00:00:00

  • Sex differences in the posteromedial cortical nucleus of the amygdala in the rat.

    abstract::It has been hypothesized that the vomeronasal system (VNS), a complex neural network implicated in the control of reproductive behaviors, is sexually dimorphic. The posteromedial cortical amygdaloid nucleus (PMCo) belongs to the group of amygdaloid structures that receive direct olfactory input from the accessory olfa...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199808030-00042

    authors: Vinader-Caerols C,Collado P,Segovia S,Guillamón A

    更新日期:1998-08-03 00:00:00

  • Effects of size and orientation change on hippocampal activation during episodic recognition: a PET study.

    abstract::To determine whether physical match between studied and tested items influences blood flow increases in the hippocampal formation associated with recognition memory, positron emission tomography (PET) was used to measure changes in regional cerebral blood flow while healthy volunteers made old/new judgements about lin...

    journal_title:Neuroreport

    pub_type: 临床试验,杂志文章

    doi:10.1097/00001756-199712220-00028

    authors: Schacter DL,Uecker A,Reiman E,Yun LS,Bandy D,Chen K,Cooper LA,Curran T

    更新日期:1997-12-22 00:00:00

  • Resiliency of cortical neural networks against cascaded failures.

    abstract::Network tools have been extensively applied to study the properties of brain functional and anatomical networks. In this paper, resiliency of Caenorhabditis elegans cortical networks against cascaded failures is studied. To this end, directed network formed by chemical connections and undirected network formed by elec...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000000421

    authors: Jalili M

    更新日期:2015-08-19 00:00:00

  • Elk with a long incubation prion disease phenotype have a unique PrPd profile.

    abstract::The transmissible spongiform encephalopathies (TSEs) invariably result in fatal neurodegeneration and accumulation of PrP, an abnormal form of the host prion protein PrP, encoded by the PRNP gene. A naturally occurring polymorphism (methionine/valine) at PRNP codon 129 is associated with variation in relative disease ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e3282f1ca2f

    authors: O'Rourke KI,Spraker TR,Zhuang D,Greenlee JJ,Gidlewski TE,Hamir AN

    更新日期:2007-12-03 00:00:00

  • Enhancement of electrically evoked startle-like responses by tetanic stimulation of the superior colliculus.

    abstract::Single-pulse unilateral electrical stimulation of either the amygdala or the inferior colliculus elicited startle-like responses in chloral hydrate anesthetized rats. EMG responses to intracranial stimulation were recorded from the anterior biceps femoris muscles. The EMG responses were generally enhanced following un...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200210070-00015

    authors: Lin C,Wan X,Zhao W,Ma C,Ma C,Gao Y,Zhou Y,Yeomans JS,Li L

    更新日期:2002-10-07 00:00:00

  • Transient expression of the NR2C subunit of the NMDA receptor in developing rat brain.

    abstract::Pharmacologically distinct NMDA-glutamate receptor subtypes have been reported in brain. We have studied the developmental expression of the mRNA encoding the NMDA receptor NR2C subunit in the rat brain by in situ hybridization. In contrast with the adult where no hybridization signal was detected in the hippocampus, ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199304000-00018

    authors: Pollard H,Khrestchatisky M,Moreau J,Ben Ari Y

    更新日期:1993-04-01 00:00:00

  • Leptin immunoreactivity in the central nervous system in normal and diabetic rats.

    abstract::An anti-leptin polyclonal antiserum was used to detect leptin-immunoreactivity (-ir) in the central nervous system in rats. Leptin-ir was found in perikaryon and processes of neurons in the hypothalamus, including the paraventricular nucleus, and in several regions in the brainstem, including the nucleus of the solita...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199902050-00042

    authors: Li HY,Wang LL,Yeh RS

    更新日期:1999-02-05 00:00:00

  • Sex differences in the latency of the late event-related potential mental rotation effect.

    abstract::Sex differences in event-related potentials were examined in 23 women and 24 men during a mental rotation task. We found an early (130-400 ms) and a late (400-700 ms) ERP mental rotation effect. The late rotation effect, which is thought to indicate the onset of the cognitive process of mental rotation, emerged about ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e3282f519b3

    authors: Gootjes L,Bruggeling EC,Magnée T,Van Strien JW

    更新日期:2008-02-12 00:00:00

  • Sensory funneling of liminal multiple- point air-puff stimulation produces dramatic reduction in reaction time but relatively invariant P300 somatosensory evoked potential.

    abstract::Sensory funneling of liminal multiple-point air-puff stimulation on the skin was evaluated by measuring somatosensory evoked potentials (SEPs), reaction time (RT) and subjective detection threshold. Single-point air-puffs at the threshold intensity, and 2-point and 3-point air-puffs (10 mm apart) of the same intensity...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199910190-00014

    authors: Hashimoto I,Yoshikawa K,Kimura T

    更新日期:1999-10-19 00:00:00

  • Cue-induced renewal of heroin place preference: involvement of the basolateral amygdala.

    abstract::It is well established that re-exposure to a context paired with the effects of drugs of abuse can renew extinguished drug seeking behavior. A context, however, typically includes several stimuli, which may differ in their ability to control drug-oriented behaviors. Hence, the primary objective of this study was to as...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000000084

    authors: Cummins E,Boughner E,Leri F

    更新日期:2014-03-26 00:00:00

  • Human short latency cortical responses to somatosensory stimulation. A high resolution EEG study.

    abstract::Human short-latency cortical responses to median nerve stimulation were investigated with a new high resolution electroencephalography technology that markedly enhanced spatial details of somatosensory-evoked potentials (SEPs). Maximum amplitude potentials were estimated over contralateral and/or frontal-mesial scalp ...

    journal_title:Neuroreport

    pub_type: 临床试验,杂志文章

    doi:10.1097/00001756-199710200-00011

    authors: Urbano A,Babiloni F,Babiloni C,Ambrosini A,Onorati P,Rossini PM

    更新日期:1997-10-20 00:00:00

  • Auditory sensory memory in 2-year-old children: an event-related potential study.

    abstract::Auditory sensory memory is assumed to play an important role in cognitive development, but little is known about it in young children. The aim of this study was to estimate the duration of auditory sensory memory in 2-year-old children. We recorded the mismatch negativity in response to tone stimuli presented with dif...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e3282f97867

    authors: Glass E,Sachse S,von Suchodoletz W

    更新日期:2008-03-26 00:00:00

  • Hypoxia enhances the migration and invasion of human glioblastoma U87 cells through PI3K/Akt/mTOR/HIF-1α pathway.

    abstract::Widespread invasiveness, represented by the invasion and migration, is the most important characteristic of glioblastoma multiforme (GBM) and is the main reason for therapeutic failure and recurrence of the tumor. Hypoxia is one of the main microenvironment in determining tumor invasiveness. Therefore, intense efforts...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000001156

    authors: Huang W,Ding X,Ye H,Wang J,Shao J,Huang T

    更新日期:2018-12-12 00:00:00

  • Grating and plaid chrominance motion influences the suppressed ocular following response.

    abstract::Involuntary eye movements to foveal stimulation were measured in a monkey while it performed a fixation task. Second-order plaid motion generated higher velocities of eye movements than did first-order gratings, yet the latency of the early following response was no different for grating or plaid motion. Nevertheless,...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199902050-00032

    authors: Guo K,Benson PJ

    更新日期:1999-02-05 00:00:00

  • Processing of presenilin 1 in brains of patients with Alzheimer's disease and controls.

    abstract::Mutations in the presenilin genes are involved in the aetiology of the majority of familial early-onset Alzheimer disease (AD) cases. Presenilin 1 (PS1) is proteolytically processed in vivo, resulting in the accumulation of N-terminal approximately 27-28 kDa and C-terminal approximately 18 kDa derivatives. To examine ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199705060-00030

    authors: Hendriks L,Thinakaran G,Harris CL,De Jonghe C,Martin JJ,Sisodia SS,Van Broeckhoven C

    更新日期:1997-05-06 00:00:00

  • Positioning of retinotopic areas and patterning of cerebral cortex layout.

    abstract::We examined the positioning of human retinotopic areas, which were considered to be homologous with the macaque visual cortices, by applying computational geometry to MRI and fMRI data sets. We found a similarity between the positional relationship of the retinotopic areas in the human and macaque visual cortex, despi...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200501190-00003

    authors: Ejima Y,Takahashi S

    更新日期:2005-01-19 00:00:00

  • Song memory in female birds: neuronal activation suggests phonological coding.

    abstract::Male Bengalese finches sing complex song sequences during courtship. To examine the female perception of sequence complexity, we tested female auditory processing with respect to sequential differences in the caudomedial nidopallium and caudomedial mesopallium. Repeated song presentations caused lower expression of th...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e32833730b7

    authors: Kato Y,Kato M,Hasegawa T,Okanoya K

    更新日期:2010-04-21 00:00:00

  • Caffeine exposure sensitizes rats to the reinforcing effects of cocaine.

    abstract::The present study examined the effect of pre-exposure to a moderate dose of caffeine (20 mg kg-1) on the acquisition of self-administration of cocaine (0.125 mg kg-1/infusion or 0.25 mg kg-1/infusion) in the rat. Rats pre-exposed to caffeine acquired self-administration more rapidly. Furthermore, sensitization to coca...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199101000-00013

    authors: Horger BA,Wellman PJ,Morien A,Davies BT,Schenk S

    更新日期:1991-01-01 00:00:00

  • Free radical scavenger protects against inner hair cell loss after cochlear ischemia.

    abstract::We investigated the protective effects of edaravone, a free radical scavenger, against ischemic damage of inner hair cells (IHCs) in gerbils. Cochlear ischemia was induced in the animals by occluding the vertebral arteries bilaterally for 15 min. Edaravone (1 mg/kg, i.v.) or saline was administered 1 h after ischemia....

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200310060-00025

    authors: Maetani T,Hakuba N,Taniguchi M,Hyodo J,Shimizu Y,Gyo K

    更新日期:2003-10-06 00:00:00

  • Cerebro-cerebellar functional connectivity revealed by the laterality index in tool-use learning.

    abstract::The function of the lateral part of the human cerebellum was investigated through cerebro-cerebellar functional connectivity. We propose a laterality index method to reveal a functional and possibly anatomical pathway between the cerebral cortex and the cerebellum. The brain activity involved in learning a visually-gu...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199902050-00022

    authors: Tamada T,Miyauchi S,Imamizu H,Yoshioka T,Kawato M

    更新日期:1999-02-05 00:00:00

  • Brainstem microstimulation differentially inhibits pudendal motoneuron reflex inputs.

    abstract::Sensory information from the genitourinary tract is transmitted to perineal muscle reflex circuits in the spinal cord and to the medullary reticular formation (MRF). This is the first report of a functional descending connection between neurons in the MRF and sensory inputs of the pudendal motoneuron reflex circuitry....

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199801260-00030

    authors: Johnson RD,Hubscher CH

    更新日期:1998-01-26 00:00:00

  • Evidence that L-arginine possesses proconvulsant effects mediated through nitric oxide.

    abstract::Increasing evidence suggests a neurotransmitter role for NO in the mammalian CNS. We have now studied the behavioural and electrocortical (ECoG) profile of rats injected into the lateral cerebral ventricle (ICV) with L-arginine (L-arg), the endogenous donor of the guanidino group from which NO physiologically originat...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199105000-00014

    authors: Mollace V,Bagetta G,Nisticò G

    更新日期:1991-05-01 00:00:00

  • High glutamate decreases S100B secretion stimulated by serum deprivation in astrocytes.

    abstract::S100B is a calcium-binding protein expressed and secreted by astrocytes, playing a neurotrophic role in neighboring cells. A protective role of the S100B against glutamate-induced excitotoxicity has recently been proposed. We investigated S100B secretion in rat hippocampal astrocytes exposed to high concentrations of ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200208270-00009

    authors: Gonçalves D,Karl J,Leite M,Rotta L,Salbego C,Rocha E,Wofchuk S,Gonçalves CA

    更新日期:2002-08-27 00:00:00

  • beta-N-methylamino-L-alanine is a low-affinity agonist of metabotropic glutamate receptors.

    abstract::beta-N-methylamino-L-alanine (L-BMAA) is an excitotoxin whose neurodegenerative effects are associated with its agonist properties at the N-methyl-D-aspartate (NMDA) receptor. We measured the effects of L-BMAA on inositol phosphate (InsP) formation in primary cultured striatal neurons. This culture is almost devoid of...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199110000-00014

    authors: Manzoni OJ,Prezeau L,Bockaert J

    更新日期:1991-10-01 00:00:00

  • Purkinje cell loss accompanies motor impairment in rats developing at altered gravity.

    abstract::We have previously reported that the developmental exposure of rats to altered gravity (1.65 g) from gestational day 8 to postnatal day 21 impacts motor functions and cerebellar structure. The present study examined whether the decrease in cerebellar mass accompanied by impaired performance on a rotorod in hypergravit...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200512190-00014

    authors: Sajdel-Sulkowska EM,Nguon K,Sulkowski ZL,Rosen GD,Baxter MG

    更新日期:2005-12-19 00:00:00

  • AMPA glutamate receptors and their flip and flop mRNAs in human hippocampus.

    abstract::AMPA-preferring glutamate receptor genes gluR1-4 undergo alternative splicing into flip and flop mRNA isoforms. In the rodent hippocampus, gluR1 and gluR2 isoforms are differentially expressed. We have studied their distribution in human hippocampus. As in the rat, flop isoforms predominate over flip in dentate gyrus,...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:

    authors: Eastwood SL,Burnet PW,Beckwith J,Kerwin RW,Harrison PJ

    更新日期:1994-06-27 00:00:00

  • Peripheral PAR-2 triggers thermal hyperalgesia and nociceptive responses in rats.

    abstract::Protease-activated receptor-2 (PAR-2), a member of the G protein-coupled, seven trans-membrane domain receptor family, is activated by trypsin/tryptase and present in various tissues including the primary sensory neurons, playing a role in development of neurogenic inflammation. The present study examined if activatio...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200103260-00020

    authors: Kawabata A,Kawao N,Kuroda R,Tanaka A,Itoh H,Nishikawa H

    更新日期:2001-03-26 00:00:00