Purkinje cell loss accompanies motor impairment in rats developing at altered gravity.

abstract：:Monoamine oxidase A (MAOA) enzymatically degrades biogenic amines such as norepinephrine, dopamine, and serotonin, and plays a key role in the regulation of their neurotransmission. Allelic variations at the MAOA locus have been implicated in the neurobiology of aggression and impulsivity. We investigated the possible...

journal_title：Neuroreport

authors： Lee BT,Ham BJ

更新日期：2008-03-26 00:00:00

abstract：:The pattern of immunoreactivity for amyloid precursor (APP) and B-cell lymphoma protooncogene (Bcl-2) proteins in the rat retina was studied after intravitreal injection of basic fibroblast growth factor (bFGF) or transforming growth factor-beta (TGFbeta). In normal control retinas, intense immunostaining of APP and B...

journal_title：Neuroreport

authors： Chen ST,Jen A,Gentleman SM,Jen LS

更新日期：1999-02-25 00:00:00

abstract：:Apolipoprotein E (apoE) and the beta-amyloid peptide are both found in the senile plaques associated with Alzheimer's disease. Several studies have recently determined that apoE can prevent beta-amyloid fibril (Abetaf) formation in vitro. In vivo, apoE is normally associated with a lipid source. We show that both reco...

journal_title：Neuroreport

authors： Beffert U,Poirier J

更新日期：1998-10-05 00:00:00

abstract：:GLYX-13 (threonine-proline-proline-threonine-amide) is an amidated di-pyrrolidine that acts as a functional partial agonist at the glycine site on N-methyl-D-aspartate glutamate receptors (NMDARs). GLYX-13 can both increase NMDAR conductance at NR2B-containing receptors, and reduce conductance of non-NR2B-containing r...

journal_title：Neuroreport

authors： Stanton PK,Potter PE,Aguilar J,Decandia M,Moskal JR

更新日期：2009-08-26 00:00:00

abstract：:The effects of diazepam and D-amphetamine on spontaneous, vestibular- and visually-induced eye movements were studied in the restrained goldfish. These animals showed a stereotyped pattern of spontaneous eye movements that scanned the visual field in the horizontal plane. Fourier analysis of these eye movements reveal...

journal_title：Neuroreport

authors： Salas C,Navarro F,Torres B,Delgado-Garcia JM

更新日期：1992-02-01 00:00:00

abstract：:The study was conducted to investigate the effect of serotonin depletion on nitric oxide-induced meningeal vascular response and cerebrovascular nociception. Nitroglycerin was infused i.v. to control and serotonin-depleted rats. Pial circulation was monitored by intravital fluorescent videomicroscopy and Fos immunorea...

journal_title：Neuroreport

authors： Srikiatkhachorn A,Anuntasethakul T,Phansuwan-Pujito P,Patumraj S,Kasantikul V

更新日期：2001-04-17 00:00:00

abstract：:Densities of serotonin transporters (5-HTT) in the postmortem neocortex of behaviorally assessed Alzheimer's disease (AD) patients and aged controls were measured by radioligand binding with [3H]citalopram. It was found that 5-HTT sites in the temporal cortex of AD patients with prominent antemortem anxiety were unalt...

journal_title：Neuroreport

authors： Tsang SW,Lai MK,Francis PT,Wong PT,Spence I,Esiri MM,Keene J,Hope T,Chen CP

更新日期：2003-07-18 00:00:00

abstract：:(-)-Epigallocatechin-3-gallate (EGCG) is the most abundant polyphenolic extract in green tea and it has attracted increasing attention for its multiple bioactive effects. However, the mechanisms by which EGCG exerts its neuroprotective actions in Alzheimer's disease (AD) are presently lacking. In the present study, a ...

journal_title：Neuroreport

authors： Guo Y,Zhao Y,Nan Y,Wang X,Chen Y,Wang S

更新日期：2017-07-05 00:00:00

abstract：:Galanin, oxytocin and cholecystokinin (CCK) are peptides that influence feeding behaviour. Galanin has been found to stimulate food intake and oxytocin and CCK have been suggested to be satiety agents. The present study was performed in order to investigate if galanin influences the secretion of oxytocin and CCK as a ...

journal_title：Neuroreport

authors： Björkstrand E,Hulting AL,Meister B,Uvnäs-Moberg K

更新日期：1993-01-01 00:00:00

abstract：:Protease-activated receptor-2 (PAR-2), a member of the G protein-coupled, seven trans-membrane domain receptor family, is activated by trypsin/tryptase and present in various tissues including the primary sensory neurons, playing a role in development of neurogenic inflammation. The present study examined if activatio...

journal_title：Neuroreport

authors： Kawabata A,Kawao N,Kuroda R,Tanaka A,Itoh H,Nishikawa H

更新日期：2001-03-26 00:00:00

abstract：:Latexin is a novel 29 kDa protein which is expressed in a subpopulation of neurones in the lateral cerebral cortex of adult rats. Here, we report the distribution of immunohistochemically detectable latexin in the rat brain during early phases of development. Latexin was first detected at embryonic day 11 (E11) along ...

journal_title：Neuroreport

authors： Takiguchi-Hayashi K,Arimatsu Y

更新日期：1995-01-26 00:00:00

abstract：:Interleukin-6 (IL-6) is a neurotrophic cytokine, however, its direct effect on nerve regeneration has not been well characterized. We therefore examined the effect of IL-6 on neurite regeneration using the rat dorsal root ganglion. IL-6 significantly enhanced neurite regeneration from transected nerve terminals. We al...

journal_title：Neuroreport

authors： Shuto T,Horie H,Hikawa N,Sango K,Tokashiki A,Murata H,Yamamoto I,Ishikawa Y

更新日期：2001-04-17 00:00:00

abstract：:As the most numerous cell type in the brain, astrocytes are coupled via gap junction channels. It is believed that communication among astrocytes is normally regulated by extracellular ions, neurotransmitters and neuromodulators. However, the level of astrocytic coupling is altered in abnormal conditions such as strok...

journal_title：Neuroreport

authors： Bani-Yaghoub M,Felker JM,Naus CC

更新日期：1999-12-16 00:00:00

abstract：:The neuroprotective effects of netrin-1 after spinal cord injury and its specific molecular mechanisms have not been elucidated. In our study, Western blot, transferase UTP nick end labeling staining and immunofluorescence staining first showed that netrin-1 significantly decreased the expression levels of caspase-3, ...

journal_title：Neuroreport

authors： Gao K,Niu J,Dang X

更新日期：2020-05-07 00:00:00

abstract：:We studied the neural activation associated with the expectancy of emotional stimuli using whole brain fMRI. Fifteen healthy subjects underwent fMRI scanning during which they performed a warned reaction task using emotional pictures carrying pleasant, unpleasant, or neutral content. The task involved an expected or u...

journal_title：Neuroreport

authors： Ueda K,Okamoto Y,Okada G,Yamashita H,Hori T,Yamawaki S

更新日期：2003-01-20 00:00:00

abstract：:To test the hypothesis that the pedunclopontine tegmental nucleus (PPTg) plays a role in anxiety, rats with electrolytic lesions of the PPTg were tested in two animal models of anxiety, the elevated plus maze and the social interaction tests. Histological analysis showed that lesions were concentrated on the caudal ha...

journal_title：Neuroreport

authors： Podhorna J,Franklin KB

更新日期：1998-06-01 00:00:00

abstract：:Phenylketonuria is the most common, inherited aminoacidopathy associated with brain injury. To date, no study has focused on the neuropathology of the genetic mouse model of phenylketonuria, BTBR-Pah(enu2). We examined dendritic spines and synapses in the CA1 and prefrontal cortex among the wild-type, heterozygous, an...

journal_title：Neuroreport

authors： Liang L,Gu X,Lu L,Li D,Zhang X

更新日期：2011-08-24 00:00:00

abstract：:Oscillatory activity is a ubiquitous property of brain signals, and yet relatively few studies have investigated how the phase of such ongoing oscillations affects our cognition. One of the main findings in this field is that the phase of electroencephalography (EEG) in the alpha band can affect perception of millisec...

journal_title：Neuroreport

authors： Jalali A,Tata MS,Gruber AJ,Luczak A

更新日期：2019-04-10 00:00:00

abstract：:Items in working memory guide visual attention toward a memory-matching object. Recent studies have shown that when searching for an object this attentional guidance can be modulated by knowing the probability that the target will match an item in working memory. Here, we recorded the P3 and contralateral delay activi...

journal_title：Neuroreport

authors： Kawashima T,Matsumoto E

更新日期：2016-03-23 00:00:00

abstract：:A polymorphism of the apolipoprotein E gene, in particular the epsilon 4 allele (ApoE4), has been associated with impaired neuronal phospholipid metabolism and synapse reorganization and has been implicated in several neurodegenerative disorders. Since selective neuronal cell lose and aberrant axonal reorganization re...

journal_title：Neuroreport

authors： Blümcke I,Brockhaus A,Scheiwe C,Rollbrocker B,Wolf HK,Elger CE,Wiestler OD

更新日期：1997-03-24 00:00:00

abstract：:The present study examined the effect of pre-exposure to a moderate dose of caffeine (20 mg kg-1) on the acquisition of self-administration of cocaine (0.125 mg kg-1/infusion or 0.25 mg kg-1/infusion) in the rat. Rats pre-exposed to caffeine acquired self-administration more rapidly. Furthermore, sensitization to coca...

journal_title：Neuroreport

authors： Horger BA,Wellman PJ,Morien A,Davies BT,Schenk S

更新日期：1991-01-01 00:00:00

abstract：:Previous studies using magnetoencephalographic (MEG) recordings have revealed neuronal populations responding to discrete auditory stimuli in the supratemporal cortex of the human brain. We used the novel whole-head magnetometer (Neuromag-122) to determine whether regions outside the auditory cortex are activated by a...

journal_title：Neuroreport

authors： Lavikainen J,Huotilainen M,Pekkonen E,Ilmoniemi RJ,Näätänen R

更新日期：1994-12-30 00:00:00

abstract：:Leptin in the rat's nucleus accumbens (NAcc) core has previously shown to disrupt the effects of acute administration of cocaine on both locomotor activity and the phosphorylation levels of glycogen synthase kinase 3β. In the present study, we further measured the phosphorylation levels of GluA1 after bilateral microi...

journal_title：Neuroreport

authors： Lee JW,Kim WY,Kim JH

更新日期：2018-04-11 00:00:00

abstract：:The present study aimed to systematically observe the change of vanilloid receptor 1 (VR1) during inflammatory nociception induced by intraplantar injection of complete Freund's adjuvant (CFA) into the left hind paw in rats. Hot plate latency (HPL) was used to evaluate resulting thermal hyperalgesia and immunohistoche...

journal_title：Neuroreport

authors： Luo H,Cheng J,Han JS,Wan Y

更新日期：2004-03-22 00:00:00

abstract：:Calcitonin gene-related peptide (CGRP) and adrenomedullin are structurally similar neuropeptides acting as potent vasodilators of blood pressure and mediator of inflammation in skin. Revealing the expression pattern of their common receptor-Calcitonin gene-related peptide receptor (Calcrl) in their targeted cells is i...

journal_title：Neuroreport

authors： Gong Y,Wei JP,Wang TH,Zhong HB,Liao XH

更新日期：2020-08-05 00:00:00

abstract：:Intracerebral or intraspinal grafting of genetically modified primary fibroblasts has been shown to enhance functional recovery in several models of CNS disease, including spinal cord injury. Most of these studies utilized retrovirus vectors. In this report, we describe in vitro conditions for genetically modifying pr...

journal_title：Neuroreport

authors： Liu Y,Himes BT,Tryon B,Moul J,Chow SY,Jin H,Murray M,Tessler A,Fischer I

更新日期：1998-04-20 00:00:00

abstract：:We describe a method for applying the carbocyanine dye DiI to the rat heart that takes advantage of the dye's lipophilic properties and its ability to diffuse easily into tissues, and results in specific retrograde labelling of cardiac vagal preganglionic neurones in the medulla oblongata. Most of the labelled neurone...

journal_title：Neuroreport

authors： Corbett EK,Batten TF,Kaye JC,Deuchars J,McWilliam PN

更新日期：1999-04-26 00:00:00

abstract：:The aim of this study was to define the effects of a potent inhibitor of tyrosine phosphatases, sodium orthovanadate (0.1-100 microM for up to 48 h), on dentate gyrus cells (DGC) in culture. Treatment with 100 microM orthovanadate evoked a delayed form of cell death. To examine the possible involvement of apoptosis in...

journal_title：Neuroreport

authors： Figiel I,Kaczmarek L

更新日期：1997-07-28 00:00:00

abstract：:The neuropeptide nociceptin/orphanin FQ (N/OFQ) is implicated in many biological functions, including nociception, locomotor activity, stress and anxiety, drinking and food-intake. N/OFQ has also been reported to play a facilitatory role in acute kainate-induced seizures. The aim of the present study was to investigat...

journal_title：Neuroreport

authors： Binaschi A,Zucchini S,Bregola G,Rodi D,Mazzuferi M,Reinscheid RK,Simonato M

更新日期：2003-05-06 00:00:00

abstract：:Humans are able to correct an ongoing movement very quickly in response to a suddenly moving target. Such fast responses possibly bypass the motor cortex and if so, one would expect that damage to the motor cortex would not greatly affect them. A group of children with congenital spastic hemiplegia were asked to move ...

journal_title：Neuroreport

authors： Smits-Engelsman BC,Rameckers EE,Duysens J

更新日期：2009-01-07 00:00:00