Abstract:
:We describe a method for applying the carbocyanine dye DiI to the rat heart that takes advantage of the dye's lipophilic properties and its ability to diffuse easily into tissues, and results in specific retrograde labelling of cardiac vagal preganglionic neurones in the medulla oblongata. Most of the labelled neurones were found bilaterally in the nucleus ambiguus (81%), with a few sparsely distributed in the dorsal motor vagal nucleus (6.5%), and in an intermediate area located between these two nuclei (12.5%). We contend that the method of applying DiI crystals to the surface of the heart is a more efficient, accurate and reproducible method of retrograde labelling than the injection of tracers into this very delicate tissue.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Corbett EK,Batten TF,Kaye JC,Deuchars J,McWilliam PNdoi
10.1097/00001756-199904260-00004subject
Has Abstractpub_date
1999-04-26 00:00:00pages
1177-81issue
6eissn
0959-4965issn
1473-558Xjournal_volume
10pub_type
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