Abstract:
:To investigate the effect of the N-terminal Slit2 protein on neuronal survival and development, recombinant human N-terminal Slit2 (N-Slit2) was assayed against isolated embryonic chick dorsal root ganglion sensory, ciliary ganglion and paravertebral sympathetic neurons. N-Slit2 promoted significant levels of neuronal survival and neurite extension in all of these populations. The protein was also assayed against postnatal mouse dorsal root ganglion neurons and found to promote neuronal survival in a similar manner. These findings suggest the Slit proteins may play an important role during development of the nervous system, mediating cellular survival in addition to the well documented role these proteins play in axonal and neuronal chemorepulsion.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Piper M,Nurcombe V,Reid K,Bartlett P,Little Mdoi
10.1097/00001756-200212030-00041subject
Has Abstractpub_date
2002-12-03 00:00:00pages
2375-8issue
17eissn
0959-4965issn
1473-558Xjournal_volume
13pub_type
杂志文章相关文献
NEUROREPORT文献大全abstract::Prefrontal delay-period activity represents a neural mechanism for the active maintenance of information and needs to be controlled by some signal to appropriately operate working memory. To examine whether reward-delivery acts as this signal, the effects of delay-period activity in response to unexpected reward-deliv...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32833776a3
更新日期:2010-03-31 00:00:00
abstract::Direct currents (DC) applied directly to central nervous system structures produce substantial and long-lasting effects in animal experiments. We tested the functional effects of very weak scalp DC (< 0.5 mA, 7 s) on the human motor cortex by assessing the changes in motor potentials evoked by transcranial magnetic br...
journal_title:Neuroreport
pub_type: 临床试验,杂志文章
doi:10.1097/00001756-199807130-00020
更新日期:1998-07-13 00:00:00
abstract::Nerve damage often leads to nervous system dysfunction and neuropathic pain. The serine-threonine kinases receptor-interacting protein 1 (RIP1) and 3 (RIP3) are associated with inflammation and cell necrosis. This study aimed to explore the role of RIP1 and RIP3 in sciatic nerve chronic constriction injury (CCI) in mi...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001120
更新日期:2018-11-07 00:00:00
abstract::Autophagy and neurogenesis play a pivotal role in maintaining cellular homeostasis of neurons in the brain. Endurance exercise (EXE) serves as a potent regulator of both autophagy and neurogenesis in the hippocampus of the brain; however, the underlying molecular mechanisms of the dual expression remains unclear. Thus...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001431
更新日期:2020-04-08 00:00:00
abstract::Recent studies have discussed the role of the cerebellum in not only motor but also cognitive functions, and in particular, fronto-executive operations. Similar to a previous study on hemineglect patients, we recorded eye movements during a visual search task to investigate patients with isolated infarction of the cer...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000177015.75096.b6
更新日期:2005-09-08 00:00:00
abstract::The so-called 40 Hz oscillations are found at almost all stages of visual processing are thought to play a critical role in perception. The goal of this investigation was to look at the presence of stimulus-specific oscillations in the lateral posterior-pulvinar complex of the thalampus (LP-P) for which the oscillatio...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199511270-00017
更新日期:1995-11-27 00:00:00
abstract::This study was undertaken to establish a method for the culture of organotypic spinal cord slices. A long-term organotypic spinal cord slice culture was conducted from postnatal rats. Lumbar spinal cord was isolated, and meninges were removed from the spinal cord. The spinal cord was embedded in 4% agarose, and was se...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000892
更新日期:2017-11-08 00:00:00
abstract::The ventral cochlear tract in the brain stem to pons was transected on one side in two groups of adult rats. In one group simple transection was performed, while in the other group tissue from embryos (E14-E16) was used to cover the lesion site. While rats receiving simple transection without transplantation showed no...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199812010-00009
更新日期:1998-12-01 00:00:00
abstract::The pathogenesis of cerebral ischemia/reperfusion (I/R) involves cytokine/chemokine production, inflammatory cell influx, astrogliosis, cytoskeletal protein degradation and breakdown of the blood-brain barrier. (-)-Naloxone is able to reduce infarct volume and has been used as a therapeutic agent for cerebral I/R inju...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200105080-00038
更新日期:2001-05-08 00:00:00
abstract::Previous studies in adult rats have demonstrated that the neurotrophin, brain-derived neurotrophic factor (BDNF), is present in virtually all cells of the pituitary intermediate lobe. In the present study, we demonstrate that cells cultured from adult intermediate lobe pituitary (ILP) rapidly lose their BDNF immunorea...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199703240-00005
更新日期:1997-03-24 00:00:00
abstract::The aim of the present study was to examine the effects of nicotinamide, a co-factor in the electron transport chain, on the relationship between methamphetamine (MA)-induced striatal dopamine (DA) depletion and energy metabolism change. Four injections of MA (10 mg/kg, i.p.) at 2 h intervals resulted in decreases of ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199705260-00018
更新日期:1997-05-27 00:00:00
abstract:OBJECTIVE:The traditional Chinese medicine, Dendrobium nobile Lindl. polysaccharides (DNLP), reportedly has neuroprotective effects. However, its effects following ischemic stroke remain unclear. This study aimed to explore the role and mechanism of DNLP in experimental models of inflammation and apoptosis. METHODS:In...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001562
更新日期:2020-12-14 00:00:00
abstract::The reduced steroids 3 alpha-hydroxy-5 alpha-pregnan-20-one (allopregnanolone) and 3 alpha,21-di-hydroxy-5 alpha-pregnan-20-one (allotetrahydroDOC) are potent ligands of GABAA receptors. This study examined the possible modulatory effect of these metabolites on GABA inhibition of somatostatin release in cultured hypot...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199510020-00025
更新日期:1995-10-02 00:00:00
abstract::Recently, we have demonstrated that bone marrow stem cells can differentiate into retinal nerve cells. In the present study, we show a new and efficient strategy for transplanting bone marrow stem cells into the retina. When bone marrow stem cells were injected into the vitreous cavity of untreated eyes, only very few...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000176517.96475.18
更新日期:2005-08-22 00:00:00
abstract::Satiety signals from the gastrointestinal tract travel via vagal afferents to the nucleus of the solitary tract (NTS) in the brain stem, the first central relay in a neural network which controls food intake. The non-competitive NMDA antagonist MK-801 facilitates food intake in rats by acting on the NTS. Here we repor...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200008210-00002
更新日期:2000-08-21 00:00:00
abstract::The hippocampus is well known to contribute to episodic memory encoding. Here we used functional magnetic resonance imaging to investigate the hippocampal response to exponentially varying encoding demands while forming associations between faces and names. We found that only the left hippocampus exhibited a stepped m...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3283340d36
更新日期:2010-01-06 00:00:00
abstract::Evidence exists that motilin immunoreactivity is highly expressed in Purkinje cells. In this study, immunohistochemistry and whole-cell patch-clamp recording were performed to investigate the spatial distribution and electrophysiological effects of motilin receptors in the cerebellum. We show here that motilin recepto...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e328273bc98
更新日期:2007-08-27 00:00:00
abstract::Selective degeneration of hypothalamic orexin neurons, a hallmark of pathology in narcolepsy patients, is in part reproduced in hypothalamic slice cultures by application of an endogenous excitotoxin quinolinic acid. Depolarized membrane potential may be responsible for the vulnerability of orexin neurons to excitotox...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200508010-00005
更新日期:2005-08-01 00:00:00
abstract::To test the combined effect of high glucose and decreased Na+/K+-pump activity, a condition which closely mimics the diabetic state, on nerve ionic currents, changes in action potential and membrane current induced by high glucose in the presence of ouabain were investigated using voltage clamp analysis in rat single ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200008030-00040
更新日期:2000-08-03 00:00:00
abstract::Following ventral root avulsion in neonatal animals, the degeneration of spinal motoneurons occurs by an apoptotic-like morphological pathway. In adult animals, however, the mechanism of degeneration of injured motoneurons is still controversial. Because caspases are important mediators of apoptosis, we have investiga...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200103050-00022
更新日期:2001-03-05 00:00:00
abstract::Recently, we have generated transgenic mice (designated as SJLB) carrying human N279K mutant tau, one of the tau mutations causing parkinsonism linked to chromosome 17 (FTDP-17). SJLB mice mimic some features of behavioral alterations and neuronal pathology of patients with Alzheimer's disease. To investigate how tau ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e328333b0e0
更新日期:2009-12-09 00:00:00
abstract::Event related potentials (ERP) were recorded from 29 electrode positions in 10 normal subjects while they performed a simplified version of the Wisconsin Card Sorting Test (WCST). The design focused on ERP differences between early and late trials within each WCST series. Topographic and dipole analyses confirmed the ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199803090-00034
更新日期:1998-03-09 00:00:00
abstract::This study aimed to investigate effects of observing the own body being touched on the functional topography of the somatosensory homunculus. We used neuromagnetic source imaging to map the topography in primary somatosensory cortex (SI) while manipulating the visibility of a touched hand. Participants were either abl...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e328301a629
更新日期:2008-06-11 00:00:00
abstract::We examined the induction of progesterone receptor-immunoreactive (PR-ir) cells by estrogen in the rat preoptic area and ventromedial hypothalamic nucleus. Ovariectomized young (3-month-old) and old (24-month-old) female rats were treated with estrogen or cholesterol for 4 days. Estrogen significantly increased PR-ir ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32833c5b6f
更新日期:2010-08-04 00:00:00
abstract::Retinal gamma-aminobutyric acid type C (GABA[C]) receptors are believed to consist of rho subunits. The pharmacological properties of GABA(C) receptors appear to vary among different species. Since the mouse is an important model for gene targeting and behavioral studies, this study was aimed at cloning rho subunits i...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199801260-00010
更新日期:1998-01-26 00:00:00
abstract::We evaluated the effects of chemical lesions on hindpaw inflammation-induced Fos protein expression in spinoparabrachial neurons that were retrogradely labeled by Fluoro-Gold. The descending serotoninergic and noradrenergic pathways were destroyed by the selective neurotoxins, 5,7-DHT and DSP-4, respectively. After 5,...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199906030-00024
更新日期:1999-06-03 00:00:00
abstract::We inserted microelectrodes in eye movement-evoking cortices (EMECs) of cats and examined whether neurones in the EMECs received sensory input from guide signals and fired prior to saccades. The five EMECs were the medial wall of the hemisphere under the cruciate sulcus, the medical and lateral bank of the presylvian ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199610020-00024
更新日期:1996-10-02 00:00:00
abstract::In dorsal unpaired median (DUM) neurones isolated from the terminal ganglion of the cockroach Periplaneta americana two types of Ca2+ currents were found: a transient one activated by lower depolarizations (LVA) and a sustained one activated by higher voltage jumps (HVA). Both currents were strongly reduced by 100 mic...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199405000-00001
更新日期:1994-05-09 00:00:00
abstract::We screened proteins for interaction with presenilin (PS) 1, and cloned the full-length cDNA of human delta-catenin, which encoded 1225 amino acids. Yeast two-hybrid assay, GST binding assay and immunoprecipitation demonstrated that delta-catenin interacted with a hydrophilic loop region in the endoproteolytic C-termi...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199902250-00022
更新日期:1999-02-25 00:00:00
abstract::Intrinsic circuitry in the barrel cortex has been shown to be readily modifiable in response to changes in the patterns of sensory input, even in adult animals. It is believed that sensory experience modifies synaptic circuits by imposing specific patterns of repetitive presynaptic and postsynaptic coactivity, i.e. by...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199511270-00007
更新日期:1995-11-27 00:00:00