Sensory-specific satiety-related olfactory activation of the human orbitofrontal cortex.

Abstract:

:When a food is eaten to satiety, its reward value decreases. This decrease is usually greater for the food eaten to satiety than for other foods, an effect termed sensory-specific satiety. In an fMRI investigation it was shown that for a region of the orbitofrontal cortex the activation produced by the odour of the food eaten to satiety decreased, whereas there was no similar decrease for the odour of a food not eaten in the meal. This effect was shown both by a voxel-wise SPM contrast (p <0.05 corrected) and an ANOVA performed on the mean percentage change in BOLD signal in the identified clusters of voxels (p <0.006). These results show that activation of a region of the human orbitofrontal cortex is related to olfactory sensory-specific satiety.

journal_name

Neuroreport

journal_title

Neuroreport

authors

O'Doherty J,Rolls ET,Francis S,Bowtell R,McGlone F,Kobal G,Renner B,Ahne G

doi

10.1097/00001756-200003200-00046

subject

Has Abstract

pub_date

2000-03-20 00:00:00

pages

893-7

issue

4

eissn

0959-4965

issn

1473-558X

journal_volume

11

pub_type

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