Abstract:
:The effects of C-type natriuretic peptide (CNP) on the hypothalamo-pituitary-adrenal system response to different stressors was studied. Various doses of CNP (0.2, 2, 4 microg) were injected into the lateral cerebral ventricle of freely moving rats 30 min before stress and activation of the adrenal was measured by plasma corticosterone. CNP did not affect basal corticosterone secretion in the doses applied, but inhibited in a dose-dependent manner the increase in plasma corticosterone induced by ether stress, electric shock and restraint. CNP exerted a more profound inhibitory effect on the response to ether stress than on that to electric shock or restraint. These results suggest that CNP acts centrally and to a different extent on the responses to different stresses.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Jászberényi M,Bujdosó E,Telegdy Gdoi
10.1097/00001756-199808030-00032subject
Has Abstractpub_date
1998-08-03 00:00:00pages
2601-3issue
11eissn
0959-4965issn
1473-558Xjournal_volume
9pub_type
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