Abstract:
:We investigated the effect of nitric oxide (NO) on N-methyl-D-aspartate (NMDA)-induced changes in levels of dopamine (DA) and its metabolite in the striatum using in vivo microdialysis. Local administration of 1mM NMDA into the striatum significantly augmented DA release in the striatum. Simultaneous administration of -5mM N(G)-nitro-L-arginine methyl ester (-NAME), a NO synthase inhibitor, into the striatum significantly potentiated NMDA-induced DA release. This effect of L-NAME was completely reversed in the presence of 50mM L-arginine (L-Arg). Administration of 1 mM NMDA significantly decreased the levels of dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA). This effect of NMDA was not affected by concurrent administration of L-NAME. This study provides in vivo evidence for the involvement of NO in NMDA-induced DA release.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Shibata M,Araki N,Ohta K,Hamada J,Shimazu K,Fukuuchi Ydoi
10.1097/00001756-199601310-00055subject
Has Abstractpub_date
1996-01-31 00:00:00pages
605-8issue
2eissn
0959-4965issn
1473-558Xjournal_volume
7pub_type
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