Nitric oxide regulates NMDA-induced dopamine release in rat striatum.

Abstract:

:We investigated the effect of nitric oxide (NO) on N-methyl-D-aspartate (NMDA)-induced changes in levels of dopamine (DA) and its metabolite in the striatum using in vivo microdialysis. Local administration of 1mM NMDA into the striatum significantly augmented DA release in the striatum. Simultaneous administration of -5mM N(G)-nitro-L-arginine methyl ester (-NAME), a NO synthase inhibitor, into the striatum significantly potentiated NMDA-induced DA release. This effect of L-NAME was completely reversed in the presence of 50mM L-arginine (L-Arg). Administration of 1 mM NMDA significantly decreased the levels of dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA). This effect of NMDA was not affected by concurrent administration of L-NAME. This study provides in vivo evidence for the involvement of NO in NMDA-induced DA release.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Shibata M,Araki N,Ohta K,Hamada J,Shimazu K,Fukuuchi Y

doi

10.1097/00001756-199601310-00055

subject

Has Abstract

pub_date

1996-01-31 00:00:00

pages

605-8

issue

2

eissn

0959-4965

issn

1473-558X

journal_volume

7

pub_type

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