Abstract:
:In Purkinje cells from cerebellar slice cultures, low-threshold Ca spike (LTS) gives rise to complex bursts in the soma that resemble the complex spike induced by climbing fibers stimulation. We show that LTS is reduced by T-type and R-type Ca channel blockers (SNX-482, nickel, or mibefradil). We propose that LTS is generated by openings of T-type Ca channels (alpha-1G and/or alpha-1I subunits) and R-type Ca channels (alpha-1E subunit isoforms with a weak sensitivity to SNX-482 and to nickel). Using mibefradil we show that climbing fiber stimulation activates LTS, which contributes to the shape of the response. This Ca entry may be involved in Ca-dependent synaptic plasticity of the parallel fiber input induced by climbing fiber activation.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Cavelier P,Lohof AM,Lonchamp E,Beekenkamp H,Mariani J,Bossu JLdoi
10.1097/WNR.0b013e3282f4cb96subject
Has Abstractpub_date
2008-02-12 00:00:00pages
299-303issue
3eissn
0959-4965issn
1473-558Xpii
00001756-200802120-00008journal_volume
19pub_type
杂志文章相关文献
NEUROREPORT文献大全abstract::To investigate the effect of the N-terminal Slit2 protein on neuronal survival and development, recombinant human N-terminal Slit2 (N-Slit2) was assayed against isolated embryonic chick dorsal root ganglion sensory, ciliary ganglion and paravertebral sympathetic neurons. N-Slit2 promoted significant levels of neuronal...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200212030-00041
更新日期:2002-12-03 00:00:00
abstract::We used positron emission tomography to investigate whether tactile motion discrimination activates the dorsal visual stream in congenitally blind (CB) participants compared with sighted controls. The tactile stimuli consisted of either static dots, dots moving coherently in one of two possible directions, or in rando...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3283279909
更新日期:2009-04-22 00:00:00
abstract::S100B is a calcium binding protein from astrocytes that regulates protein phosphorylation by binding to substrates and protein kinases. S100B might also regulate protein phosphatases and this was investigated for protein phosphatase 2B (calcineurin). The results indicate that S100B (5-10 microM) increased the activity...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200402090-00021
更新日期:2004-02-09 00:00:00
abstract::5-[125I]iodo-3-(2(S)-azetidinylmethoxy)pyridine ([125I]5-I-A-85380) was evaluated in the mouse as a potential in vivo imaging ligand for central nicotinic acetylcholine receptors (nAChRs). After i.v. administration of [125I]5-I-A-85380, peak brain levels of radioactivity were measured within 1 h and declined slowly ov...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199807130-00030
更新日期:1998-07-13 00:00:00
abstract::Since the characterization of orphanin FQ (OFQ), the endogenous ligand of ORL1 receptor, much work has focused on its physiological functions. OFQ was reported to antagonize the effect of opioid-induced antinociception, although its mechanism remains obscure. In the present study, whole-cell patch clamp recording tech...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199806220-00034
更新日期:1998-06-22 00:00:00
abstract::Epidemiological data show correlations between hypercholesterolemia and Alzheimer's disease (AD). We test the hypothesis that hypercholesterolemia modulates Abeta deposition in mice overexpressing the human APP695 Swedish mutation (K670N and M671L) (TgAPPsw). Feeding mice a high fat/high cholesterol (HFHC) diet for 7-...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200203250-00019
更新日期:2002-03-25 00:00:00
abstract::Propofol is widely used for induction and maintenance of anaesthesia, which causes a rapid loss of consciousness. So far the mechanisms underlying the effect of propofol are still largely unknown. Here, we found that microinjection of propofol in the lateral hypothalamus caused a significant decrease in wakefulness an...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001292
更新日期:2019-10-09 00:00:00
abstract::We studied whether pro-survival Akt was activated after transient focal cerebral ischemia and whether it inhibited pro-apoptotic Bad. Phosphorylation of Akt (serine-473) was enhanced in cortex after 1-hour ischemia, and also after 1h and 6 h of reperfusion, but it returned back to that in controls by 24 h. After this ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200110290-00046
更新日期:2001-10-29 00:00:00
abstract::Transcranial direct current stimulation (tDCS) is a technique for noninvasively stimulating specific cortical regions of the brain with small (<2 mA) and constant direct current on the scalp. tDCS has been widely applied, not only for medical treatment, but also for cognitive and somatosensory function enhancement, mo...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000283
更新日期:2014-12-17 00:00:00
abstract::Interleukin-6 (IL-6) is a neurotrophic cytokine, however, its direct effect on nerve regeneration has not been well characterized. We therefore examined the effect of IL-6 on neurite regeneration using the rat dorsal root ganglion. IL-6 significantly enhanced neurite regeneration from transected nerve terminals. We al...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200104170-00043
更新日期:2001-04-17 00:00:00
abstract::Focal lesions of the visual cortex induce deafferentiation, excitotoxic cell death as well as functional reorganization in the surrounding tissue. The intracellular second messenger calcium is involved in a wide range of cellular responses including excitotoxicity and functional reorganization following cortical injur...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200110080-00009
更新日期:2001-10-08 00:00:00
abstract::Event-related potentials (ERPs) were measured from 24 chronic closed head injury (CHI) patients and 18 age- and education-matched controls. The oddball paradigm was applied while subjects were watching a silent movie. The standard (p=0.8) sound of 75 ms duration had a basic frequency of 500 Hz with harmonic partials o...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200105250-00043
更新日期:2001-05-25 00:00:00
abstract::Phenylketonuria is the most common, inherited aminoacidopathy associated with brain injury. To date, no study has focused on the neuropathology of the genetic mouse model of phenylketonuria, BTBR-Pah(enu2). We examined dendritic spines and synapses in the CA1 and prefrontal cortex among the wild-type, heterozygous, an...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3283495acc
更新日期:2011-08-24 00:00:00
abstract::Methamphetamine (METH)-induced dopaminergic neurotoxicity is associated with hyperthermia. We investigated the effect of several neuronal nitric oxide synthase (nNOS) inhibitors on METH-induced hyperthermia and striatal dopaminergic neurotoxicity. Administration of METH (5 mg/kg; q. 3 h x 3) to Swiss Webster mice prod...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200009110-00022
更新日期:2000-09-11 00:00:00
abstract::Antisera were produced against synthetic peptides predicted from the recent cloning of a delta opioid receptor, DOR-1. Confocal microscopic examination of immunostained spinal cord sections revealed that DOR-1 immunoreactive (-ir) nerve fibers and terminals form a moderately dense plexus within the superficial dorsal ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199312000-00041
更新日期:1993-12-13 00:00:00
abstract::We investigated the protective effects of edaravone, a free radical scavenger, against ischemic damage of inner hair cells (IHCs) in gerbils. Cochlear ischemia was induced in the animals by occluding the vertebral arteries bilaterally for 15 min. Edaravone (1 mg/kg, i.v.) or saline was administered 1 h after ischemia....
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200310060-00025
更新日期:2003-10-06 00:00:00
abstract::The neural foundation of age-related declines in prospective memory was explored using event-related brain potentials (ERPs). Consistent with previous research, a decline in the efficiency of prospective memory was observed in older adults that reflected a decrease in veridical prospective responses and an increase in...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200109170-00020
更新日期:2001-09-17 00:00:00
abstract::The aim of the present study was to determine if both inactivating and non-inactivating potassium currents occur in skeletal muscle cells at early times in culture. Whole cell current was recorded from embryonic muscle cells within 4-10 h of plating. We found that in the cells which had an outward current, half had a ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199204000-00007
更新日期:1992-04-01 00:00:00
abstract::The amounts of three adenylyl cyclase (AC) subtypes in membranes from brain obtained post-mortem from patients with dementia of Alzheimer type (DAT) and controls were studied by Western blotting using polyclonal antibodies. AC subtypes were characterized by preabsorption by complementary peptides, species difference, ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199611250-00033
更新日期:1996-11-25 00:00:00
abstract::We used multiple-labelling immunofluorescence, intracellular dye injection, electrophysiological recording and confocal microscopy to examine the expression of immunoreactivity to protein kinase C (PKC) and protein kinase A (PKA) in sympathetic ganglia of guinea-pigs. PKCalpha and PKCgamma were widespread in vasoconst...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199904060-00015
更新日期:1999-04-06 00:00:00
abstract::In contrast to mechanisms mediating synaptic plasticity, the pharmacological basis of perceptual learning remains to be clarified. Here we report that a specific form of perceptual learning is influenced by GABAergic mechanisms. We induced perceptual learning by Hebbian co-activation of the skin of the tip of the righ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200309150-00018
更新日期:2003-09-15 00:00:00
abstract::We evaluated the effects of chemical lesions on hindpaw inflammation-induced Fos protein expression in spinoparabrachial neurons that were retrogradely labeled by Fluoro-Gold. The descending serotoninergic and noradrenergic pathways were destroyed by the selective neurotoxins, 5,7-DHT and DSP-4, respectively. After 5,...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199906030-00024
更新日期:1999-06-03 00:00:00
abstract::Functional homology between human and macaque visual cortices has provided an important cue to functional subdivisions of the human visual cortex, but it is unclear beyond V1. We estimated the sizes and the visual field eccentricity functions of the extrastriate visual areas of human brains using MRI and fMRI measurem...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200308260-00008
更新日期:2003-08-26 00:00:00
abstract::Prolonged activation of brain N-methyl-D-aspartic acid (NMDA) receptors increases intraneuronal (Ca2+) and nitric oxide (NO) synthesis, and may be responsible for neuronal death in acute brain insults and chronic neurodegenerative diseases. NO can be converted in vitro to toxic hydroxyl (OH) radical. Using microdialys...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199310000-00018
更新日期:1993-10-25 00:00:00
abstract::Subcortical visual inputs to motion-selective cortex in primates survive after damage to the primary visual cortex (area 17/V1). Activation of human motion cortex was examined using scalp electrodes in a V1-damaged hemianope. Blind field motion-onset visual evoked potentials (VEPs) shared many of the characteristics a...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199911260-00024
更新日期:1999-11-26 00:00:00
abstract::The pattern of distribution and co-localization of nitric oxide synthase (NOS) and quinacrine fluorescence (indicative of vesicular adenosine 5'-triphosphate, ATP), and co-localization of NADPH-diaphorase (NADPH-d) activity and NOS-immunoreactivity in the myenteric plexus of pre-term human fetal (6-17 weeks of gestati...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200001170-00002
更新日期:2000-01-17 00:00:00
abstract::We examined the role of main and external cuneate nuclei neurons in processing sensory information during forelimb passive movement. We recorded activity of neurons using circular and figure-eight trajectories, at different speeds, in anaesthetized rats. A multivariate regression analysis was performed to correlate ne...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200203040-00004
更新日期:2002-03-04 00:00:00
abstract::Regional brain activity associated with intentional and incidental memory retrieval was studied with PET. Previously studied and new words were presented in either an intentional or an incidental memory task. Type of task was crossed with an encoding manipulation ('deep' vs 'shallow') which varied the probability that...
journal_title:Neuroreport
pub_type: 临床试验,杂志文章
doi:10.1097/00001756-199703240-00045
更新日期:1997-03-24 00:00:00
abstract::N-methyl-D-aspartate (NMDA) receptors are hetero-oligomeric receptor-channel complexes composed of NR1 and NR2 subunits. Subunit composition determines the properties of NMDA receptor subtypes. However, the molecular mechanisms regulating their subunit composition are unknown. Using reverse transcription (RT)-competit...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199712010-00015
更新日期:1997-12-01 00:00:00
abstract::We investigated the role of melatonin in the induction of gastric lesions induced by water immersion restraint stress or centrally administered thyrotropin-releasing hormone (TRH). Melatonin (0.1-1 ng) injected intracisternally (i.c) 30 min prior to stress dose-dependently inhibited the induction of gastric lesions by...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199707070-00041
更新日期:1997-07-07 00:00:00