Fast vigilance decrement in closed head injury patients as reflected by the mismatch negativity (MMN).

Abstract:

:Event-related potentials (ERPs) were measured from 24 chronic closed head injury (CHI) patients and 18 age- and education-matched controls. The oddball paradigm was applied while subjects were watching a silent movie. The standard (p=0.8) sound of 75 ms duration had a basic frequency of 500 Hz with harmonic partials of 1000 Hz and 1500 Hz, whereas these frequencies for the pitch deviant were each 10% higher. The frequencies of the duration deviant matched with those of the standard but was 25 ms in duration. The MMN (mismatch negativity), generated by the brain's automatic auditory change-detector mechanism, was elicited by both deviants. No significant differences in the MMN latency or amplitude for either pitch or duration deviants were found between the groups. However, the MMN amplitude for the pitch deviant decreased in the patient group during the experiment considerably faster than in controls, suggesting a faster vigilance decrement in the patients.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Kaipio ML,Novitski N,Tervaniemi M,Alho K,Ohman J,Salonen O,Näätänen R

doi

10.1097/00001756-200105250-00043

subject

Has Abstract

pub_date

2001-05-25 00:00:00

pages

1517-22

issue

7

eissn

0959-4965

issn

1473-558X

journal_volume

12

pub_type

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