Abstract:
:Activated NF-kappaB contributes to cerebral infarction by triggering a neuro-inflammatory response. Rats subjected to 90min middle cerebral artery occlusion developed a cortical infarct of 20+/-4% of hemispheric volume (n = 8). Treatment with the proteasome inhibitor CVT-634 resulted in a significantly smaller infarct of 13+/-2% (n = 7, p<0.01) and 12+/-2% (n = 8, p<0.001) of hemispheric volume at 1 day and 7 days, respectively. Since regional cerebral blood flows for the core and penumbral regions were not affected, we concluded that all animals received the same ischemic insult The reduction in infarction persisted for 7 days. This is the first indication that a proteasome inhibitor can reduce infarct volume in a focal model of cerebral ischemia.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Buchan AM,Li H,Blackburn Bdoi
10.1097/00001756-200002070-00041subject
Has Abstractpub_date
2000-02-07 00:00:00pages
427-30issue
2eissn
0959-4965issn
1473-558Xjournal_volume
11pub_type
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