Monoamine neurons in the human brain stem: anatomy, magnetic resonance imaging findings, and clinical implications.

Abstract:

:By using high-resolution, conventional, and neuromelanin-sensitive magnetic resonance imaging techniques, we reviewed the normal anatomy of the nuclei consisting of monoamine neurons such as dopaminergic, noradrenergic, and serotoninergic neurons and noted the changes in these nuclei that occur in some degenerative and psychiatric disorders. Multimodal MR images can directly or indirectly help in identifying the substantia nigra, locus ceruleus, and raphe nuclei that contain monoamine neurons. Neuromelanin-sensitive magnetic resonance imaging can detect signal alterations in the substantia nigra pars compacta and/or locus ceruleus that occur in Parkinson's disease and psychiatric disorders such as depression and schizophrenia. This technique seems to be promising for the noninvasive evaluation of the pathological or functional changes in the monoamine system that occur in degenerative and psychiatric disorders.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Sasaki M,Shibata E,Tohyama K,Kudo K,Endoh J,Otsuka K,Sakai A

doi

10.1097/WNR.0b013e328315a637

subject

Has Abstract

pub_date

2008-11-19 00:00:00

pages

1649-54

issue

17

eissn

0959-4965

issn

1473-558X

journal_volume

19

pub_type

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