Abstract:
:By using high-resolution, conventional, and neuromelanin-sensitive magnetic resonance imaging techniques, we reviewed the normal anatomy of the nuclei consisting of monoamine neurons such as dopaminergic, noradrenergic, and serotoninergic neurons and noted the changes in these nuclei that occur in some degenerative and psychiatric disorders. Multimodal MR images can directly or indirectly help in identifying the substantia nigra, locus ceruleus, and raphe nuclei that contain monoamine neurons. Neuromelanin-sensitive magnetic resonance imaging can detect signal alterations in the substantia nigra pars compacta and/or locus ceruleus that occur in Parkinson's disease and psychiatric disorders such as depression and schizophrenia. This technique seems to be promising for the noninvasive evaluation of the pathological or functional changes in the monoamine system that occur in degenerative and psychiatric disorders.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Sasaki M,Shibata E,Tohyama K,Kudo K,Endoh J,Otsuka K,Sakai Adoi
10.1097/WNR.0b013e328315a637subject
Has Abstractpub_date
2008-11-19 00:00:00pages
1649-54issue
17eissn
0959-4965issn
1473-558Xjournal_volume
19pub_type
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