Serotonin in the raphe nuclei: regulation by light and an endogenous pacemaker.


:Temporal changes of serotonin (5-HT) content in the median (MRN) and dorsal (DRN) raphe nuclei were measured in rats kept under various lighting conditions. Serotonin content in the MRN and DRN under light-dark (LD) condition showed diurnal rhythmicity, with a peak during early light phase and a trough during the dark phase. In constant dark (DD) condition, a single peak was observed and was out of phase to the 5-HT peak found under LD condition. Animals exposed to constant light (LL) after 2 days in DD showed marked increase in 5-HT after lights on. These results suggest that changes in 5-HT in the MRN and DRN are regulated by an endogenous pacemaker and by light.






Cagampang FR,Yamazaki S,Otori Y,Inouye SI




Has Abstract


1993-10-25 00:00:00












  • Phospholipase A2-induced changes in AMPA receptor: an autoradiographic study.

    abstract::The expression of long-term potentiation and learning of a classical conditioning task increase [3H]-AMPA binding in hippocampus. Phospholipase A2 (PLA2) has been proposed to underly these changes, as PLA2 treatment of membrane preparations increases the affinity of AMPA receptors for agonists. We demonstrate here tha...


    pub_type: 杂志文章


    authors: Tocco G,Massicotte G,Standley S,Thompson RF,Baudry M

    更新日期:1992-06-01 00:00:00

  • Nocistatin, a peptide reversing acute and chronic morphine tolerance.

    abstract::It has been reported that intracerebroventricular (i.c.v.) injection of nociception/orphanin FQ (OFQ) can antagonize morphine analgesia, whereas i.c.v. OFQ antibody can reverse morphine tolerance. Nocistatin (NST) is a recently characterized neuropeptide possessing an antagonizing effect on OFQ. Here we examine whethe...


    pub_type: 杂志文章


    authors: Sun RQ,Zhao CS,Wang HJ,Jing Z,Wang W,Yang K,Wang Y,Chang JK,Han JS

    更新日期:2001-06-13 00:00:00

  • Non-conscious choice in cutaneous backward masking.

    abstract::A simple but effective method has been devised to explore backward masking in cutaneous sensation. In this method a weak electrical shock to the palm (test stimulus) is followed by a stronger shock to the same site (masking stimulus). By combining this stimulation strategy with a choice reaction time paradigm, it has ...


    pub_type: 临床试验,杂志文章


    authors: MacIntyre NJ,McComas AJ

    更新日期:1996-06-17 00:00:00

  • Autoantigen Ku in the brain. Developmentally regulated expression and subcellular localization.

    abstract::A double-stranded DNA end-binding factor with high levels of expression in brain and testis of adult mice was identified as the Ku protein, earlier described as an autoantigen in connective tissue diseases and found to be essential for recombination of the immunoglobulin genes and DNA repair. High Ku levels were found...


    pub_type: 杂志文章


    authors: Bakalkin G,Yakovleva T,Hurd YL,Nussenzweig A,Li GC,Terenius L

    更新日期:1998-06-22 00:00:00

  • NADH can enter into astrocytes and block poly(ADP-ribose) polymerase-1-mediated astrocyte death.

    abstract::Poly(ADP-ribose) polymerase-1 consumes NAD to catalyze poly(ADP-ribosyl)ation of target proteins, which modulates various biological functions. However, excessive poly(ADP-ribose) polymerase-1 activation mediates oxidative cell death. Our recent studies have indicated that NAD can enter into astrocytes to prevent poly...


    pub_type: 杂志文章


    authors: Zhu K,Swanson RA,Ying W

    更新日期:2005-08-01 00:00:00

  • N-methyl-D-aspartate (NMDA)-mediated muscle relaxant action of flupirtine in rats.

    abstract::The present study examined in urethane-chloralose anaesthetized rats whether N-methyl-D-aspartate (NMDA) is involved in the depressant effect of flupirtine on the monosynaptic Hoffmann (H)-reflex recorded from plantar foot muscles and on polysynaptic flexor reflexes recorded from tibialis muscle. Intrathecal administr...


    pub_type: 杂志文章


    authors: Schwarz M,Block F,Pergande G

    更新日期:1994-10-03 00:00:00

  • A derivative of a rigid glutamate analog protects the retina from excitotoxicity.

    abstract::In the retina, the activation of metabotropic glutamate receptors (mGluRs) reduces the toxic effect of N-methyl-D-aspartate (NMDA). We have induced NMDA-mediated excitotoxicity in the adult rat retina by a single intraocular injection of NMDA. The damage that resulted was estimated by assessing the NMDA-induced loss o...


    pub_type: 杂志文章


    authors: Siliprandi R,Lipartiti M,Fadda E,Arban R,Kozikowski AP,Manev H

    更新日期:1994-06-02 00:00:00

  • Selective interference reveals dissociation between memory for location and colour.

    abstract::The aim was to study whether there is indication of a dissociation in processing of visuospatial and colour information in working memory in humans. Experimental subjects performed visuospatial and colour n-back tasks with and without visuospatial and colour distractive stimuli presented in the middle of the delay per...


    pub_type: 杂志文章


    authors: Vuontela V,Rämä P,Raninen A,Aronen HJ,Carlson S

    更新日期:1999-08-02 00:00:00

  • Glutamate microinjection in the medial septum of rats decreases paradoxical sleep and increases slow wave sleep.

    abstract::The role of the medial septum in suppressing paradoxical sleep and promoting slow wave sleep was suggested on the basis of neurotoxic lesion studies. However, these conclusions need to be substantiated with further experiments, including chemical stimulation studies. In this report, the medial septum was stimulated in...


    pub_type: 杂志文章


    authors: Mukherjee D,Kaushik MK,Jaryal AK,Kumar VM,Mallick HN

    更新日期:2012-05-09 00:00:00

  • Auditory event-related potentials as a function of abstract change magnitude.

    abstract::Event-related potentials were recorded in healthy volunteers to test the accuracy of the human brain to extract, preattentively, auditory abstract rules. The abstract rule was determined by the frequency relationship between two pure tones forming a pair. The standard pairs had identical tone frequency, whereas the de...


    pub_type: 杂志文章


    authors: Carral V,Corral MJ,Escera C

    更新日期:2005-02-28 00:00:00

  • Decomposing N2 NOGO wave of event-related potentials into independent components.

    abstract::Inconsistencies in previous attempts to localize the N2 wave in the GO/NOGO task led to the present investigation. The inconsistencies were probably because of heterogeneity of psychological operations involved in GO/NOGO tasks. We applied the independent component analysis to a collection of individual event-related ...


    pub_type: 杂志文章


    authors: Kropotov JD,Ponomarev VA

    更新日期:2009-12-09 00:00:00

  • MK-801 decreases striatal and cortical GAD65 mRNA levels.

    abstract::Levels of mRNAs encoding for the two isoforms of glutamate decarboxylase, GAD67 and GAD65, were quantified in the rat striatum and cerebral cortex following single injections of the non-competitive NMDA receptor antagonist MK-801. Acute MK-801 induced a dose-dependent decrease in GAD65 mRNA levels in ventral sectors o...


    pub_type: 杂志文章


    authors: Laprade N,Soghomonian JJ

    更新日期:1995-10-02 00:00:00

  • Temporal structure of implicit motor imagery in visual hand-shape discrimination as revealed by MEG.

    abstract::We investigated the spatio-temporal brain activity on the time scale of several milliseconds related to the mental rotation task requiring judgements of hand orientation, using a whole-cortex MEG (magnetoencephalography) system. Neuronal activity in the visual cortex was observed approximately 100-200 ms from stimulus...


    pub_type: 临床试验,杂志文章


    authors: Kawamichi H,Kikuchi Y,Endo H,Takeda T,Yoshizawa S

    更新日期:1998-04-20 00:00:00

  • Neural correlates of the modified Stroop effect in post-traumatic stress disorder: an event-related potential study.

    abstract::Previous studies have provided electrophysiological evidence for attentional abnormalities in patients with post-traumatic stress disorder (PTSD). The present study examined the electrophysiological activity of trauma-exposed patients with or without a PTSD during a modified Stroop task. The PTSD group showed a reduce...


    pub_type: 杂志文章


    authors: Chen X,Wei D,Dupuis-Roy N,Du X,Qiu J,Zhang Q

    更新日期:2012-12-19 00:00:00

  • Increased trkB mRNA expression by axotomized motoneurones.

    abstract::It has been previously demonstrated that members of the neurotrophin family may prevent death of motoneurones following axotomy. Here we report that the expression of mRNA for full-length trkB, which is a signal transducing receptor for BDNF and NT-4, increases transiently in spinal motoneurones after axotomy in adult...


    pub_type: 杂志文章


    authors: Piehl F,Frisén J,Risling M,Hökfelt T,Cullheim S

    更新日期:1994-02-24 00:00:00

  • Viability and survival of hNT neurons determine degree of functional recovery in grafted ischemic rats.

    abstract::We recently reported behavioral improvements following intrastriatal transplantation of cryopreserved cultured human neuroteratocarcinoma-derived cells (hNT neurons) in rats with cerebral ischemia induced by occlusion of the middle cerebral artery. In the present study, the viability and survival of hNT neurons were e...


    pub_type: 杂志文章


    authors: Borlongan CV,Saporta S,Poulos SG,Othberg A,Sanberg PR

    更新日期:1998-08-24 00:00:00

  • Acute ethanol decreases NPY mRNA but not POMC mRNA in the arcuate nucleus.

    abstract::The acute effects of ethanol and acetaldehyde on neuropeptide mRNA expression in the arcuate nucleus (ARC) was assessed. Acetaldehyde was increased in blood following ethanol with cyanamide (a potent inhibitor of aldehyde dehydrogenase) administration. Acetaldehyde is a toxin which can cause a variety of adverse effec...


    pub_type: 杂志文章


    authors: Kinoshita H,Jessop DS,Finn DP,Coventry TL,Roberts DJ,Ameno K,Ijiri I,Harbuz MS

    更新日期:2000-11-09 00:00:00

  • Induced brain magnetic activities related to salient birdsong under noisy conditions.

    abstract:OBJECTIVE:Birdsong sounds are often used to inform visually-challenged people about the presence of basic infrastructures, and therefore need to be salient in noisy urban environments. How salient sounds are processed in the brain could inform us about the optimal birdsong in such environments. However, brain activity ...


    pub_type: 杂志文章


    authors: Yano H,Soeta Y

    更新日期:2021-01-13 00:00:00

  • Amyloid beta-peptide spin trapping. I: Peptide enzyme toxicity is related to free radical spin trap reactivity.

    abstract::Synthetic beta-amyloid peptides (A betas) demonstrate lot-to-lot variation in toxicity that has not been adequately explained. Studies from our laboratory have shown that A beta toxicity may result from the ability of the peptide to promote oxidation reactions. Both A beta(1-40) and A beta(25-35) inactivate the oxidat...


    pub_type: 杂志文章


    authors: Hensley K,Aksenova M,Carney JM,Harris M,Butterfield DA

    更新日期:1995-02-15 00:00:00

  • R-citalopram prevents the neuronal adaptive changes induced by escitalopram.

    abstract::This study examined the long-term effects of the antidepressant escitalopram on rat serotonin (5-HT) neuronal activity and hippocampal neuroplasticity. In the dorsal raphe nucleus, a 2-week treatment with escitalopram (10 mg/kg/day, subcutaneous) did not modify the firing activity of 5-HT neurons, whereas a cotreatmen...


    pub_type: 杂志文章


    authors: Mnie-Filali O,Faure C,Mansari ME,Lambás-Señas L,Bérod A,Zimmer L,Sánchez C,Haddjeri N

    更新日期:2007-10-08 00:00:00

  • Expression of the neuropeptide Y Y1 receptor mRNA in the human brain: an in situ hybridization study.

    abstract::Using cRNA in situ hybridization, the regional distribution of mRNA encoding the human Y1 receptor was investigated in the normal human brain and compared with the autoradiographic distribution of putative Y1/[125I][Leu31,Pro34]PYY binding sites. Surprisingly, relatively high levels of Y1 receptor mRNA, distributed in...


    pub_type: 杂志文章


    authors: Jacques D,Tong Y,Dumont Y,Shen SH,Quirion R

    更新日期:1996-04-10 00:00:00

  • Prolonged changes in amyloid-β metabolism after a severe traumatic brain injury.

    abstract::Traumatic brain injury (TBI) is a major risk factor for Alzheimer's disease. Recent studies suggest that amyloid-beta (Aβ) deposit can be detected several years after TBI. However, it is unknown whether post-TBI Aβ deposits arise from short-term changes in Aβ metabolism or reflect a long-term sequela. To answer this q...


    pub_type: 杂志文章


    authors: Bagnato S,Andriolo M,Boccagni C,Galardi G

    更新日期:2017-03-22 00:00:00

  • PKC and tyrosine kinase involvement in amyloid beta (25-35)-induced chemotaxis of microglia.

    abstract::Microglia are activated by amyloid beta (Abeta) in vivo and in vitro, and Abeta-activated microglia may be involved in the pathogenesis of Alzheimer's disease (AD). We investigated the mechanism of microglial chemotaxis induced by Abeta (25-35), an active fragment of Abeta. Abeta (25-35) 0.1 and 1 nM stimulated microg...


    pub_type: 杂志文章


    authors: Nakai M,Hojo K,Taniguchi T,Terashima A,Kawamata T,Hashimoto T,Maeda K,Tanaka C

    更新日期:1998-10-26 00:00:00

  • Functional brain mapping of the relaxation response and meditation.

    abstract::Meditation is a conscious mental process that induces a set of integrated physiologic changes termed the relaxation response. Functional magnetic resonance imaging (fMRI) was used to identify and characterize the brain regions that are active during a simple form of meditation. Significant (p<10(-7)) signal increases ...


    pub_type: 杂志文章


    authors: Lazar SW,Bush G,Gollub RL,Fricchione GL,Khalsa G,Benson H

    更新日期:2000-05-15 00:00:00

  • Leptin in the nucleus accumbens blocks the increase of GluA1 phosphorylation induced by acute cocaine administration.

    abstract::Leptin in the rat's nucleus accumbens (NAcc) core has previously shown to disrupt the effects of acute administration of cocaine on both locomotor activity and the phosphorylation levels of glycogen synthase kinase 3β. In the present study, we further measured the phosphorylation levels of GluA1 after bilateral microi...


    pub_type: 杂志文章


    authors: Lee JW,Kim WY,Kim JH

    更新日期:2018-04-11 00:00:00

  • Central sensitization in medullary dorsal horn involves gap junctions and hemichannels.

    abstract::Central sensitization is a fundamental mechanism contributing to acute and chronic pain conditions. Our previous studies have documented a glutamatergic, purinergic and glial-dependent central sensitization that can be induced in rat medullary dorsal horn nociceptive neurons by mustard oil application to the tooth pul...


    pub_type: 杂志文章


    authors: Chiang CY,Li Z,Dostrovsky JO,Sessle BJ

    更新日期:2010-02-17 00:00:00

  • A phonological representation in the infant brain.

    abstract::In adults, neural networks for phonological processing distinct from those involved in acoustical processing are located in the left temporal lobe. We now report that by the age of 3 months, infants display phonological processing devices analogous to those found in adults. Within a stream of identical syllables, acou...


    pub_type: 临床试验,杂志文章


    authors: Dehaene-Lambertz G,Baillet S

    更新日期:1998-06-01 00:00:00

  • Retinal ganglion cell axons regenerate in the presence of intact sensory fibres.

    abstract::A novel allograft paradigm was used to test whether adult mammalian central axons regenerate within a peripheral nerve environment containing intact sensory axons. Retinal ganglion cell axon regeneration was compared following anastomosis of dorsal root ganglia grafts or conventional peripheral nerve grafts to the adu...


    pub_type: 杂志文章


    authors: King C,Bartlett C,Sauvé Y,Lund R,Dunlop S,Beazley L

    更新日期:2006-02-06 00:00:00

  • Modeling the control of reticular thalamic oscillations by neuromodulators.

    abstract::Compartmental models of thalamic reticular (RE) neurons were investigated based on current-clamp and voltage-clamp data. Spontaneous oscillations in the model arise from the interaction between inhibitory synaptic currents and the rebound burst of RE cells. These oscillations critically depend on the level of the rest...


    pub_type: 杂志文章


    authors: Destexhe A,Contreras D,Sejnowski TJ,Steriade M

    更新日期:1994-11-21 00:00:00

  • Long-term disuse of the hand affects motor imagery ability in patients with complete brachial plexus palsy.

    abstract::The purpose of this study was to examine motor imagery ability in patients with peripheral nerve disorder using the hand mental rotation task. Five patients with left total avulsion brachial plexus palsy (BPP) and 16 healthy age-matched adults participated in this study. The mean±SD time from the injury was 103.6±49.7...


    pub_type: 杂志文章


    authors: Date S,Kurumadani H,Yoshimura M,Fukae A,Onishi K,Hayashi J,Shinomiya R,Sunagawa T

    更新日期:2019-04-10 00:00:00