Abstract:
:This study shows distributions of lacZ-positive cells in the vestibular labyrinthine explants of young guinea pigs with mature ears. When adenovirus lacZ vectors were administered to the vestibular labyrinth following removal of the otoconial membrane, lacZ-positive cells were observed in the mesothelial cells in the perilymphatic space, in the sensory and supporting cells in the utricle and ampulla, and in the transitional and dark cells in the ampulla. When the otoconial membrane was preserved, lacZ-positive cells were not distributed in the utricular sensory epithelium. These findings suggest that adenovirus vectors can transform a variety of vestibular epithelial cells, but that it is difficult for adenovirus vectors to pass through the otoconial membrane.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Suzuki M,Yamasoba T,Kondo K,Kaga Kdoi
10.1097/00001756-200112210-00032subject
Has Abstractpub_date
2001-12-21 00:00:00pages
4013-7issue
18eissn
0959-4965issn
1473-558Xjournal_volume
12pub_type
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