MPP+ impairs autophagic clearance of alpha-synuclein by impairing the activity of dynein.

abstract：:In line with a possible role of vergence in orienting visual attention, we sought to study this eye movement in young children to provide insights on face perception. For this purpose, we measured the modulation in the angle of eye vergence in a sample of 39 children aged 6-36 months and compared it when presenting st...

journal_title：Neuroreport

authors： Esposito FL,Supèr H

更新日期：2018-02-07 00:00:00

abstract：:The present study examined species differences in spatial and non-spatial memory in the Morris water maze. Male Wistar rats and C57BL/6 mice were tested in a one-day water maze task in which spatial learning, retention, and non-spatial learning were assessed within 3 h. Rats and mice appeared to use different strategi...

journal_title：Neuroreport

authors： Frick KM,Stillner ET,Berger-Sweeney J

更新日期：2000-11-09 00:00:00

abstract：:Cholinergic basal forebrain neurons (CBFN) expressing the low-affinity neurotrophin receptor p75 (p75(NTR)) were previously selectively labeled in vivo with carbocyanine 3 (Cy3)-tagged anti-p75(NTR), but the applied 192IgG-conjugates recognized p75(NTR) only in rat. The antibody ME 20.4 raised against human p75(NTR) h...

journal_title：Neuroreport

authors： Härtig W,Varga C,Kacza J,Grosche J,Seeger J,Luiten PG,Brauer K,Harkany T

更新日期：2002-08-07 00:00:00

abstract：:The aim was to study the effects of an NMDA receptor antagonist on caspase-3 activation and DNA fragmentation after hypoxia-ischemia (HI) in 7-day-old rats. Animals were treated with vehicle or MK-801 (0.5 mg/kg) directly after HI and sacrificed 8, 24 or 72h later. MK-801 reduced injury (by 53%), cells positive for ac...

journal_title：Neuroreport

authors： Puka-Sundvall M,Hallin U,Zhu C,Wang X,Karlsson JO,Blomgren K,Hagberg H

更新日期：2000-09-11 00:00:00

abstract：:Oleic acid, a cis-unsaturated free fatty acid, is proposed to be involved in the protein kinase C (PKC) activation pathway. Its biological actions, however, have not been well-characterized. We examined the effects of oleic acid on acetylcholine (ACh)-gated channel currents using Torpedo nicotinic ACh receptors expres...

journal_title：Neuroreport

authors： Nishizaki T,Ikeuchi Y,Matsuoka T,Sumikawa K

更新日期：1997-02-10 00:00:00

abstract：:During vertebrate neural development, inductive signals derived from the roof plate specify dorsal neural cell types of spinal cord as well as adjacent dermomytotome. Noggin has been demonstrated to play a pivotal role in this signaling network but how its expression is regulated remains unclear. To investigate this i...

journal_title：Neuroreport

authors： Geng X,Xiao L,Tao Q,Hu R,Rupp RA,Ding X

更新日期：2003-12-02 00:00:00

abstract：:Cortical auditory categorization was assessed in 2-month-old infants at genetic risk for dyslexia and controls. Manipulated /bAk/ and /dAk/ speech stimuli were used as frequently presented standards. The neuroelectric brain responses of the control infants were highly sensitive to the phoneme boundary that separated t...

journal_title：Neuroreport

authors： van Leeuwen T,Been P,van Herten M,Zwarts F,Maassen B,van der Leij A

更新日期：2007-06-11 00:00:00

abstract：:Sciatic nerve resection leaving a 15 mm gap could not be repaired by bridging the stumps with a silicone tube prefilled with a laminin gel. However, when purified olfactory ensheathing cells (EC) were added to the gel filling the tube, successful axonal regeneration was observed in 50% of rats. With 12 mm gaps, regene...

journal_title：Neuroreport

authors： Verdú E,Navarro X,Gudiño-Cabrera G,Rodríguez FJ,Ceballos D,Valero A,Nieto-Sampedro M

更新日期：1999-04-06 00:00:00

abstract：:MicroRNAs (miRNAs) have been documented as critical regulators in ischemia/reperfusion-induced neuronal death. A better understanding of miRNA-mediated molecular mechanisms in ischemia/reperfusion-induced neuronal death may provide therapeutic targets for cerebral ischemia/reperfusion injury. A growing body of evidenc...

journal_title：Neuroreport

authors： Xiao J,Kong R,Hu J

更新日期：2018-06-13 00:00:00

abstract：:Auditory sensory memory is assumed to play an important role in cognitive development, but little is known about it in young children. The aim of this study was to estimate the duration of auditory sensory memory in 2-year-old children. We recorded the mismatch negativity in response to tone stimuli presented with dif...

journal_title：Neuroreport

authors： Glass E,Sachse S,von Suchodoletz W

更新日期：2008-03-26 00:00:00

abstract：:The present study examined the effect of peripherally applied morphine and GABA on jaw muscle electromyographic activity reflexly evoked by co-injection of glutamate into the temporomandibular joint (TMJ) of lightly anesthetized Sprague-Dawley rats of both sexes. In male but not female rats, morphine significantly sup...

journal_title：Neuroreport

authors： Cai BB,Cairns BE,Sessle BJ,Hu JW

更新日期：2001-11-16 00:00:00

abstract：:Retinal ganglion cells of the fish have the spontaneous capacity to regenerate after nerve crush, a phenomenon known to be facilitated by nerve growth factor (NGF). We have studied the high-affinity NGF receptor TrkA, during the regeneration of the tench (Tinca tinca L.) optic nerve, using immunocytochemical technique...

journal_title：Neuroreport

authors： Vecino E,Caminos E,Becker E,Rudkin BB,Evan GI,Martín-Zanca D

更新日期：1998-10-26 00:00:00

abstract：:DCC is a member of the immunoglobulin superfamily of cell adhesion molecules, whose role in the function of the adult nervous system is unknown. DCC mRNA expression was studied in adult rat dorsal hippocampal sections using in situ hybridization histochemistry. High levels of DCC transcript were detected in hippocampu...

journal_title：Neuroreport

authors： Volenec A,Bhogal RK,Moorman JM,Leslie RA,Flanigan TP

更新日期：1997-09-08 00:00:00

abstract：:Meditation is a conscious mental process that induces a set of integrated physiologic changes termed the relaxation response. Functional magnetic resonance imaging (fMRI) was used to identify and characterize the brain regions that are active during a simple form of meditation. Significant (p<10(-7)) signal increases ...

journal_title：Neuroreport

authors： Lazar SW,Bush G,Gollub RL,Fricchione GL,Khalsa G,Benson H

更新日期：2000-05-15 00:00:00

abstract：:Using in situ hybridization histochemistry and immunocytochemistry the induction of immediate early genes (IEGs) was studied in the rat superior cervical ganglion (SCG) after deafferentation, axotomy and sialectomy (removal of the submandibular gland). Control SCGs showed very low levels of IEGs, whereby Fos proteins ...

journal_title：Neuroreport

authors： Koistinaho J,Pelto-Huikko M,Sagar SM,Dagerlind A,Roivainen R,Hökfelt T

更新日期：1993-01-01 00:00:00

abstract：:Anterior cingulate integrity may be required for antidepressant response. To assess anterior cingulate processes related to treatment response, we studied error-related negativity and error positivity produced during an emotional go/no-go challenge, a task activating the rostral anterior cingulate. Twelve elderly pati...

journal_title：Neuroreport

authors： Alexopoulos GS,Murphy CF,Gunning-Dixon FM,Kalayam B,Katz R,Kanellopoulos D,Etwaroo GR,Klimstra S,Foxe JJ

更新日期：2007-02-12 00:00:00

abstract：:We examined the induction of progesterone receptor-immunoreactive (PR-ir) cells by estrogen in the rat preoptic area and ventromedial hypothalamic nucleus. Ovariectomized young (3-month-old) and old (24-month-old) female rats were treated with estrogen or cholesterol for 4 days. Estrogen significantly increased PR-ir ...

journal_title：Neuroreport

authors： Furuta M,Fukushima A,Chiba S,Sano A,Akema T,Kimura F,Funabashi T

更新日期：2010-08-04 00:00:00

abstract：:One approach to understanding the function of presenilin 1 (PS1), is to discover those proteins with which it interacts. Evidence for a function in developmental patterning came from C. elegans, in which a PS homologue was identified by screening for suppressors of a mutation in Notch/lin-12, a gene which specifies ce...

journal_title：Neuroreport

authors： Zhou J,Liyanage U,Medina M,Ho C,Simmons AD,Lovett M,Kosik KS

更新日期：1997-04-14 00:00:00

abstract：:Genetic factors are involved in variation in fetal alcohol spectrum disorders (FASD), which is also observed among various inbred mouse strains. The CD1 mouse strain is often used in toxicological and genetic experiments. However, there is little literature using this strain to study long-term neurologic abnormalities...

journal_title：Neuroreport

authors： Wei S,Xu Z,Gao J,Ding J,Xiao M

更新日期：2013-03-06 00:00:00

abstract：:The potent and selective AMPA receptor antagonist NBQX was tested for cytoprotective properties in an adult rat model of transient focal neocortical ischemia. Nineteen spontaneously hypertensive rats sustained 2 h of middle cerebral artery occlusion, followed by 22 h of recirculation. Ninety minutes following the onse...

journal_title：Neuroreport

authors： Buchan AM,Xue D,Huang ZG,Smith KH,Lesiuk H

更新日期：1991-08-01 00:00:00

abstract：:This study tested the hypothesis that inhibition of nitric oxide synthase (NOS) in the medial pontine reticular formation (mPRF) would cause decreased acetylcholine (ACh) release. Microdialysis of cat mPRF permitted measurement of ACh during states of wakefulness, non-rapid eye movement (NREM) sleep and rapid eye move...

journal_title：Neuroreport

authors： Leonard TO,Lydic R

更新日期：1995-07-31 00:00:00

abstract：:It is unclear whether the neural algorithm that underlies stereoscopic vision in birds incorporates both low level (camouflage breaking) and high level (depth ordering) comparisons of information available to each of the eyes. Both visual functions were successfully tested by examining transitive inference performance...

journal_title：Neuroreport

authors： van der Willigen RF,Frost BJ,Wagner H

更新日期：1998-04-20 00:00:00

abstract：:The whole-cell patch-clamp technique was employed to investigate the development of voltage-gated currents in cultured newt retinal pigment epithelial (RPE) cells. Freshly dissociated RPE cells were inexcitable and mainly exhibited a voltage-gated outward K+ current. Within a few days in culture RPE cells began to fla...

journal_title：Neuroreport

authors： Sakai H,Saito T

更新日期：1994-04-14 00:00:00

abstract：:The increase in neural activity in cat visual cortex associated with eye movements has been thought to reflect a replica of the motor command signal. We examined the timing of the saccade-related increase in neural activity in cat areas 17 and 18 in relation to saccade onset and offset. The increase in activity was te...

journal_title：Neuroreport

authors： Park J,Lee C

更新日期：2000-06-05 00:00:00

abstract：:Learning and memory are cognitive functions commonly impaired after surgery, especially in elderly patients. Our aim was to evaluate the effect of sevoflurane anaesthesia on episodic-like memory in young and aged wild-type mice and mice with altered nicotinic cholinergic neurotransmission (beta2KO). Mice learned objec...

journal_title：Neuroreport

authors： Wiklund A,Granon S,Faure P,Sundman E,Changeux JP,Eriksson LI

更新日期：2009-10-28 00:00:00

abstract：:Recently, we have demonstrated that bone marrow stem cells can differentiate into retinal nerve cells. In the present study, we show a new and efficient strategy for transplanting bone marrow stem cells into the retina. When bone marrow stem cells were injected into the vitreous cavity of untreated eyes, only very few...

journal_title：Neuroreport

authors： Minamino K,Adachi Y,Yamada H,Higuchi A,Suzuki Y,Iwasaki M,Nakano K,Koike Y,Mukaide H,Kiriyama N,Shigematsu A,Matsumura M,Ikehara S

更新日期：2005-08-22 00:00:00

abstract：:Diffuse axonal injury (DAI) accounts for more than 50% of all traumatic brain injury. In response to the mechanical damage associated with DAI, the abnormal proteins produced in the neurons and axons, namely, β-APP and p-tau, induce endoplasmic reticulum (ER) stress. Curcumin, a major component extracted from the rhiz...

journal_title：Neuroreport

authors： Huang T,Zhao J,Guo D,Pang H,Zhao Y,Song J

更新日期：2018-05-23 00:00:00

abstract：:Recent studies have demonstrated a loss of cannabinoid CB1 receptors in the basal ganglia in Huntington's disease (HD), but there are no data on endocannabinoid levels in this disease. In the present study, we have addressed this question by using rats with bilateral intrastriatal injections of 3-nitropropionic acid (...

journal_title：Neuroreport

authors： Lastres-Becker I,Fezza F,Cebeira M,Bisogno T,Ramos JA,Milone A,Fernández-Ruiz J,Di Marzo V

更新日期：2001-07-20 00:00:00

abstract：:After learning position discrimination in a T-maze water escape task, rats had either a 2 mm section of the middle cerebral artery removed bilaterally (bMCA) or they received a sham operation. Beginning on the day of surgery either total brain gangliosides (50 mg kg-1) or saline were administered daily for five days. ...

journal_title：Neuroreport

authors： McDaniel WF,Fjordbak T,Schmidt MS,Tucker JC,Davis BK

更新日期：1991-11-01 00:00:00

abstract：:Neurotrophic factors such as brain-derived neurotrophic factor (BDNF) are assumed to provide trophic support via a target-derived, retrograde mechanism of action. However, recent studies suggest that neurotrophic factors can act in an autocrine fashion and perhaps even in an anterograde direction similar to neurotrans...

journal_title：Neuroreport

authors： Smith MA,Zhang LX,Lyons WE,Mamounas LA

更新日期：1997-05-27 00:00:00