Abstract:
:The aim was to study the effects of an NMDA receptor antagonist on caspase-3 activation and DNA fragmentation after hypoxia-ischemia (HI) in 7-day-old rats. Animals were treated with vehicle or MK-801 (0.5 mg/kg) directly after HI and sacrificed 8, 24 or 72h later. MK-801 reduced injury (by 53%), cells positive for active caspase-3 (by 39%) and DNA fragmentation (by 79%) in the cerebral cortex. Furthermore, MK-801 significantly decreased caspase-3 activity, and Western blots revealed a tendency towards decreased proteolytic cleavage of the caspase-3 proform. The data imply that NMDA receptors are involved in the activation of apoptotic processes in the immature brain after HI.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Puka-Sundvall M,Hallin U,Zhu C,Wang X,Karlsson JO,Blomgren K,Hagberg Hdoi
10.1097/00001756-200009110-00002subject
Has Abstractpub_date
2000-09-11 00:00:00pages
2833-6issue
13eissn
0959-4965issn
1473-558Xjournal_volume
11pub_type
杂志文章相关文献
NEUROREPORT文献大全abstract::Maintenance of long-term potentiation in perforant path-granule cell synapses is accompanied by increased glutamate release. Here we investigate the role of synaptophysin in release and in expression of long-term potentiation in dentate gyrus. We report that long-term potentiation was accompanied by increased endogeno...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199808030-00012
更新日期:1998-08-03 00:00:00
abstract::This study is to explore the involvement of muscarinic acetylcholine receptors/protein kinase C cascade and the mitogen-activated protein kinase pathway in the effect of huperzine A on the secretory amyloid precursor protein-alpha. Upregulation of secretory amyloid precursor protein-alpha by huperzine A was attenuated...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3280c1e28c
更新日期:2007-05-07 00:00:00
abstract::Neurotrophins are promising candidates to slow the progression of amyotrophic lateral sclerosis (ALS), a neurodegenerative disease in which spinal and cortical motoneurons selectively degenerate. In a long-term in vitro model, malonate-induced toxicity and cell death of motoneurons have been demonstrated. Here we stud...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200105250-00013
更新日期:2001-05-25 00:00:00
abstract::We constructed two replication-deficient recombinant adenovirus vectors coding human basic fibroblast growth factor (bFGF), one with and one without the interleukin-2 (IL-2) secretory signal sequence and examined their neurotrophic effects on primary neuronal cells in vitro. The primary neuronal cells were successfull...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200006260-00039
更新日期:2000-06-26 00:00:00
abstract::We have established an in-vitro coculture-system of adult rat retina with fetal midbrain explants to examine whether regenerating central nervous system axons are still able to recognize appropriate target neurons. Our results show that the retinal ganglion cell axons regenerate their axons and reinnervate the retino-...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199110000-00007
更新日期:1991-10-01 00:00:00
abstract::The tonic discharge of rat medial vestibular nucleus (MVN) neurons, and their responsiveness to GABA receptor agonists were investigated in slices prepared from aged rats (24 months old). Aged MVN neurons showed regular spontaneous activity similar to that seen in slices from young adults. However the inhibitory effec...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200112210-00022
更新日期:2001-12-21 00:00:00
abstract::This study used electroencephalogram measurements to investigate the effects of aging on oscillatory theta modulation during an audiovisual discrimination task. By a wavelet-based time-frequency analysis, age-related theta oscillation response differences were observed within a relatively restricted time range (0-500 ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000609
更新日期:2016-08-03 00:00:00
abstract::Animal models suggest that the asymmetry of monocular optokinetic nystagmus (OKN) in young infants can be explained by a direct pathway from retina to the midbrain nucleus of the optic tract. However, earlier studies with hemispherectomized infants showed no evidence for OKN responses towards the damaged cortex that c...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199909090-00006
更新日期:1999-09-09 00:00:00
abstract::Human neuroblastoma SH-SY5Y and small-cell lung carcinoma U1690 cells of neuroendocrine origin were exposed to morphine for 1 h, 3 h or 5 days. These treatments did not alter activities of AP-1, NF-kappa B and YY1 transcription factors in SH-SY5Y cells or NF-kappa B and YY1 in U1690 cells. Five-day morphine treatment,...
journal_title:Neuroreport
pub_type: 杂志文章
doi:
更新日期:1997-07-07 00:00:00
abstract::We examined the positioning of human retinotopic areas, which were considered to be homologous with the macaque visual cortices, by applying computational geometry to MRI and fMRI data sets. We found a similarity between the positional relationship of the retinotopic areas in the human and macaque visual cortex, despi...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200501190-00003
更新日期:2005-01-19 00:00:00
abstract::Changes in nitric oxide (NO) concentration and cerebral blood flow (CBF) in the parietal cortex during hypercapnoea were investigated in anaesthetized rats, using a NO-selective electrode and laser Doppler flowmetry. When hypercapnoea was induced by inhalation of 5% CO2 for 10 min, both the NO concentration and CBF in...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199703030-00036
更新日期:1997-03-03 00:00:00
abstract::Exosomes derived from Schwann cells have been known to have a variety of functions in the development and repair of the peripheral nervous system, and cyclic AMP (cAMP) is a key inducer of Schwann cell differentiation. In the present study, we aimed to study the effect of exosomes derived from differentiated Schwann c...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001435
更新日期:2020-05-07 00:00:00
abstract::In the present study we tested the hypothesis that baclofen, a GABA-B receptor agonist, attenuates methamphetamine self-administration. Fifteen rats were trained to self-administer i.v. injections of methamphetamine (0, 0.0625, 0.125 and 0.25 mg/kg/injection) on a progressive ratio schedule of reinforcement, and then ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200207020-00007
更新日期:2002-07-02 00:00:00
abstract::Although citral, which is abundantly present in lemongrass, has various actions including antinociception, how citral affects synaptic transmission has not been examined as yet. Citral activates in heterologous cells transient receptor potential vanilloid-1, ankyrin-1, and melastatin-8 (TRPV1, TRPA1, and TRPM8, respec...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000518
更新日期:2016-02-10 00:00:00
abstract::Although prenatal stress has been repeatedly shown to inhibit adult neurogenesis in the dentate gyrus of offspring, its effects on embryonic and early postnatal brain development are not well described. Here, using the cell proliferation marker 5-bromo-2'-deoxyuridine, we examine for the first time the effect of prena...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000236849.53682.6d
更新日期:2006-10-02 00:00:00
abstract::We studied the distribution of phosphorylated tau (p-tau) in neonatal and adult rat cerebrum using monoclonal antibodies that recognize distinct tau epitopes in a phosphorylation-dependent manner. In neonatal cortex, p-tau was detected in the apical dendrites and somata of pyramidal neurons as well as in axons. In adu...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199708180-00029
更新日期:1997-08-18 00:00:00
abstract::The neuropeptide nociceptin/orphanin FQ (N/OFQ) is implicated in many biological functions, including nociception, locomotor activity, stress and anxiety, drinking and food-intake. N/OFQ has also been reported to play a facilitatory role in acute kainate-induced seizures. The aim of the present study was to investigat...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200305060-00009
更新日期:2003-05-06 00:00:00
abstract::Retinal on-bipolar cells possess specialized glutamate receptors which are coupled via a G-protein to the control of a cyclic GMP (cGMP) cascade. Whole-cell voltage clamp recordings were obtained from light-responsive on-bipolar cells in retinal slices of the dogfish. Inclusion of nitroprusside in the patch-pipette so...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199210000-00006
更新日期:1992-10-01 00:00:00
abstract::Counter-stimulation reduces pain perception; however, the role of attention during this process is rarely discussed despite attention itself being a well known modulator of pain perception. This study investigated the effect of attentional modulation on pain perception during counter-stimulation using fMRI. Subjects r...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200107030-00047
更新日期:2001-07-03 00:00:00
abstract::Postulating that central IL-1 is involved in the pathogenesis of cancer anorexia we measured IL-1 alpha in cerebrospinal fluid (CSF) from anorectic tumor bearing (TB) rats and non-tumor bearing controls, and correlated their CSF IL-1 alpha with food intake and tumor weight. Food intake in controls was significantly hi...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199503270-00011
更新日期:1995-03-27 00:00:00
abstract::Functional imaging has struggled for two decades to establish a quantitative link between the neuronal activity and the change in signal obtained. This review proposes a division of neuronal activity into a component relating to the electrical discharge activity and a component relating to the size of the activated ne...
journal_title:Neuroreport
pub_type: 杂志文章,评审
doi:10.1097/00001756-200409150-00001
更新日期:2004-09-15 00:00:00
abstract::Recent association studies investigating polymorphisms in the alpha2-macroglobulin (A2M) gene provided evidence for an involvement of this protease inhibitor in the pathogenesis of Alzheimer's disease (AD). The partially overlapping pathology between AD and Parkinson's disease (PD) led us to investigate the role of A2...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200008030-00020
更新日期:2000-08-03 00:00:00
abstract::Slices of rat cingulate cortex, when incubated in magnesium-free medium, produce spontaneous epileptiform spikes. Here it is demonstrated that the metabotropic glutamate receptor (mGluR) agonists +/- trans-1-amino-cyclopentane-1,3-dicarboxylic acid (+/- Trans-ACPD), IS3R-ACPD and quisqualic acid (quis) can reduce the ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199210000-00024
更新日期:1992-10-01 00:00:00
abstract::Remote ischemic preconditioning (RIPC) is an effective regimen for neuroprotection in ischemic stroke. Exosomes are extracellular vesicles released into the blood, where they can transfer signals throughout the body. Several studies have demonstrated that RIPC leads to many changes in circulating exosomes. However, th...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001280
更新日期:2019-08-14 00:00:00
abstract::The present study examined species differences in spatial and non-spatial memory in the Morris water maze. Male Wistar rats and C57BL/6 mice were tested in a one-day water maze task in which spatial learning, retention, and non-spatial learning were assessed within 3 h. Rats and mice appeared to use different strategi...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200011090-00013
更新日期:2000-11-09 00:00:00
abstract:OBJECTIVE:Cervical spondylotic myelopathy is regarded as a chronic, special incomplete spinal cord injury, so the sensory components transmitted to thalamus decreased after distal spinal cord injury, which lead the disturbance of thalamus-cortex circuits, which might explain the alterations of clinical function of cerv...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001346
更新日期:2020-03-25 00:00:00
abstract::In the adult rat hippocampal formation, neurogenesis occurs in the dentate gyrus subgranular zone (SGZ). We used laser capture microdissection and an antidepressant-related genes microarray to analyze gene expression profiles of cells from the SGZ and from the outermost granule cell layer. Of the differentially expres...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3283350b24
更新日期:2010-01-27 00:00:00
abstract::Acid-sensing ion channels (ASICs) constitute a branch of the super-gene family of amiloride-sensitive sodium channels. So far five different ASICs have been cloned from mammalian tissues. They are activated by a drop of extracellular pH but differ with respect to effective agonist concentration, desensitization and mR...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200006050-00003
更新日期:2000-06-05 00:00:00
abstract::The spatial-temporal expression and function of Drosophila melanogaster homothorax (hth) and its vertebrate homologue Meis2 in the eye anlage show a high degree of evolutionary conservation. Both are expressed by progenitor cells ahead of the neurogenic wave front, promote rapid proliferation of these cells, and are d...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32832000ae
更新日期:2009-02-18 00:00:00
abstract::Neuroimaging techniques, such as fMRI, PET and near-infrared spectroscopy, monitor task-related neuronal activations in the brain indirectly through the associated neurovascular/metabolic responses. To assess the primary neuronal activations directly, magnetoencephalography was combined here with a mechanical modulati...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200106130-00034
更新日期:2001-06-13 00:00:00