Abstract:
:Recent association studies investigating polymorphisms in the alpha2-macroglobulin (A2M) gene provided evidence for an involvement of this protease inhibitor in the pathogenesis of Alzheimer's disease (AD). The partially overlapping pathology between AD and Parkinson's disease (PD) led us to investigate the role of A2M in PD. We performed association studies in a large sample of 328 German PD patients and 322 closely matched healthy controls. Analyzing the Val1000Ile polymorphism and a pentanucleotide deletion in the 5' splice site of exon 18 of the A2M gene we found an excess of homozygosity for the A2M deletion in early-onset PD (EOPD) patients (age at onset < 50 years) compared to late-onset PD (LOPD) patients (age at onset > 50 years; p = 0.008, p(p)c = 0.064, chi2 = 7.017). Therefore our data might indicate an age at onset modulating effect of the homozygous A2M deletion in PD.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Krüger R,Menezes-Saecker AM,Schöls L,Kuhn W,Müller T,Woitalla D,Berg D,Berger K,Przuntek H,Epplen JT,Riess Odoi
10.1097/00001756-200008030-00020subject
Has Abstractpub_date
2000-08-03 00:00:00pages
2439-42issue
11eissn
0959-4965issn
1473-558Xjournal_volume
11pub_type
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