Estrogen increases axodendritic synapses in the VMN of rats after ovariectomy.

Abstract:

:Low doses of estrogen (E) were given to ovariectomized (OVX) rats and the ventromedial hypothalamic nucleus (VMN) was examined at the ultrastructural level. Administration of 10 micrograms of E for two consecutive days resulted in an increase in the number of axodendritic synapses in the VMN in comparison to OVX rats treated with oil. The percentage of axospine and multiple synapses and the length of the postsynaptic density were unchanged by E treatment. These results provide further support for the ability of low doses of E to alter neuronal morphology.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Frankfurt M,McEwen BS

doi

10.1097/00001756-199107000-00006

subject

Has Abstract

pub_date

1991-07-01 00:00:00

pages

380-2

issue

7

eissn

0959-4965

issn

1473-558X

journal_volume

2

pub_type

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