Cocaine inhibits leptin-induced increase of the cocaine- and amphetamine-regulated transcript peptide in the nucleus accumbens in rats.

Abstract:

:Two well-known appetite-regulatory peptides, leptin and cocaine- and amphetamine-regulated transcript (CART), are known to be involved in the brain rewarding pathway. However, it is not yet known how they interact in the nucleus accumbens, an important region mediating the rewarding effects of drugs of abuse. Using the immunoassay method, we found that a microinjection of leptin into the nucleus accumbens core induces an immediate and transient increase of the CART peptide in this site, whereas these effects were inhibited by cocaine. These results expand the role of accumbal leptin to the regulation of the CART peptide and further suggest that possible interaction of these appetite-regulating peptides may be involved in cocaine-mediated rewarding effects.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Cho BR,Yoon HS,Kim WY,Vezina P,Kim JH

doi

10.1097/WNR.0000000000000822

subject

Has Abstract

pub_date

2017-08-02 00:00:00

pages

701-704

issue

11

eissn

0959-4965

issn

1473-558X

journal_volume

28

pub_type

杂志文章
  • Mesolimbic gender differences in peptide CART mRNA expression: effects of cocaine.

    abstract::The putative neurotransmitter peptide CART has been suggested to be involved in the actions of psychostimulants. We analyzed the CART mRNA expression in mesolimbic brain areas of male and ovariectomized 17beta-estradiol- (30 microg) and vehicle-treated female rats. A gender difference was noted in the accumbens shell ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199911080-00034

    authors: Fagergren P,Hurd YL

    更新日期:1999-11-08 00:00:00

  • A long-range cortical network emerging with theta oscillation in a mental task.

    abstract::Human scalp EEG has demonstrated that global coherence among distant areas increases during cognitive tasks, suggesting that oscillating neural activities work to generate global neuronal assemblies for cognitive functions. The theta oscillation in a frequency range of 4-8 Hz with large amplitudes which emerges during...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/01.wnr.0000126755.09715.b3

    authors: Mizuhara H,Wang LQ,Kobayashi K,Yamaguchi Y

    更新日期:2004-06-07 00:00:00

  • Acute adaptive changes in food intake pattern following olfactory ablation in rats.

    abstract::We determined whether acute compensatory feeding pattern changes after bulbectomy persist on a chronic basis, or whether physiological adaptation occurs to normalize acute changes. Rats were randomized to olfactory bulbectomy or sham operation; all had jugular vein catheterization. Food intake, meal number and size we...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199704140-00023

    authors: Meguid MM,Koseki M,Yang ZJ,Gleason JR,Laviano A

    更新日期:1997-04-14 00:00:00

  • pH transients due to monosynaptic activation of GABAA receptors in rat hippocampal slices.

    abstract::Extracellular pH transients were evoked in rat hippocampal brain slices by activation of a monosynaptic inhibitory pathway following pharmacological blockade of glutaminergic transmission. Repetitive stimulation in stratum radiatum near the recording site in stratum pyramidale evoked an immediate alkaline shift which ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199201000-00028

    authors: Kaila K,Paalasmaa P,Taira T,Voipio J

    更新日期:1992-01-01 00:00:00

  • Brainstem microstimulation differentially inhibits pudendal motoneuron reflex inputs.

    abstract::Sensory information from the genitourinary tract is transmitted to perineal muscle reflex circuits in the spinal cord and to the medullary reticular formation (MRF). This is the first report of a functional descending connection between neurons in the MRF and sensory inputs of the pudendal motoneuron reflex circuitry....

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199801260-00030

    authors: Johnson RD,Hubscher CH

    更新日期:1998-01-26 00:00:00

  • Endogenous phosphorylation of tau proteins in brain slices.

    abstract::Tau protein phosphorylation has been implicated as a main process that regulates microtubule dynamics. A large number of tau isoforms is generated by phosphorylation through the action of a diversity of kinases. We have analysed variations in tau phosphorylation by two-dimensional gel electrophoresis, where a great he...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199410270-00023

    authors: Araujo HM,Sutton R,Moura Neto V

    更新日期:1994-10-27 00:00:00

  • Polyamines modulate the function of transfected glutamate receptor mGluR1a.

    abstract::Metabotropic glutamate receptor mGluR1a was expressed in human embryonic kidney 293 cells. 1S,3R-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD) stimulated dose-dependently, phosphoinositide (PI) hydrolysis in transfected, but not in non-transfected cells. The polyamine spermine did not affect PI hydrolysis in th...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199306000-00059

    authors: Manev RM,Gabellini N,Manev H

    更新日期:1993-06-01 00:00:00

  • Neuronal coding of stimulus-response association rules in the motor cortex.

    abstract::Two monkeys were trained to perform wrist movements to align a pointer with visual targets. In the spatially 'compatible' condition, monkeys had to point at the target position (left/right), whereas in the 'incompatible' condition, they had to point at the position opposite to the target. A large proportion of neurone...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199412000-00014

    authors: Riehle A,Kornblum S,Requin J

    更新日期:1994-12-20 00:00:00

  • Psychophysical evidence for a general temporal processing deficit in children with dyslexia.

    abstract::The hypothesis of a general (i.e. cross-modal) temporal processing deficit in dyslexia was tested by examining rapid processing in both the auditory and the visual system in the same children with dyslexia. Participants were 10- to 12-year-old dyslexic readers and age-matched normal reading controls. Psychophysical th...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200111160-00046

    authors: Van Ingelghem M,van Wieringen A,Wouters J,Vandenbussche E,Onghena P,Ghesquière P

    更新日期:2001-11-16 00:00:00

  • Benzodiazepines modulate calcium spikes in young and adult hippocampal cells.

    abstract::GABAA receptor-independent effects of benzodiazepine receptor (BZ-R) agonists on calcium and barium spikes were recorded intracellularly in the presence of bicuculline from CA3 hippocampal cells of young and adult rats. Zolpidem (omega 1 BZ-R agonist), had no effects in young animals but decreased calcium and barium s...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199410270-00034

    authors: Rovira C,Ben-Ari Y

    更新日期:1994-10-27 00:00:00

  • Intrathecal and systemic R-phenylisopropyl-adenosine reduces scratching behaviour in a rat mononeuropathy model.

    abstract::The aim of the present study was to investigate the effect of intravenous or intrathecal (i.t.) administration of R-phenylisopropyladenosine (R-PIA), a selective A1 adenosine receptor agonist, on spontaneous scratching behaviour, a phenomenon presumably related to pain in a mononeuropathy model (sciatic nerve ligation...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199607290-00034

    authors: Sjölund KF,Sollevi A,Segerdahl M,Hansson P,Lundeberg T

    更新日期:1996-07-29 00:00:00

  • Hemodynamic signals of mixed messages during a social exchange.

    abstract::This study used functional magnetic resonance imaging to characterize hemodynamic activation patterns recruited when the participants viewed mixed social communicative messages during a common interpersonal exchange. Mixed messages were defined as conflicting sequences of biological motion and facial affect signals th...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e3283455c23

    authors: Zucker NL,Green S,Morris JP,Kragel P,Pelphrey KA,Bulik CM,LaBar KS

    更新日期:2011-06-22 00:00:00

  • The BOLD response: a new look at an old riddle.

    abstract::Functional imaging has struggled for two decades to establish a quantitative link between the neuronal activity and the change in signal obtained. This review proposes a division of neuronal activity into a component relating to the electrical discharge activity and a component relating to the size of the activated ne...

    journal_title:Neuroreport

    pub_type: 杂志文章,评审

    doi:10.1097/00001756-200409150-00001

    authors: Marcar VL,Loenneker T

    更新日期:2004-09-15 00:00:00

  • Visual form discrimination from luminance or disparity cues: functional anatomy by PET.

    abstract::With the purpose of elucidating the functional fields involved in the discrimination of visual form based either on luminance or binocular disparity cues, we used PET to measure changes in regional cerebral blood flow (rCBF) in ten volunteers while they performed visual discrimination tasks. The averaged standardized ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199411000-00039

    authors: Gulyás B,Roland PE,Heywood CA,Popplewell DA,Cowey A

    更新日期:1994-11-21 00:00:00

  • Pineal activity is under the control of retinal D1-dopaminergic pathways.

    abstract::The role of dopaminergic pathways in the retina in controlling the functional state of the pineal was investigated. Dopaminergic agents were injected into the eyes of dark-adapted chickens which were maintained in the dark. Changes in the activity of N-acetyltransferase (NAT) in the retina and pineal were then monitor...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199502000-00010

    authors: Morgan IG,Boelen MK,Miethke P

    更新日期:1995-02-15 00:00:00

  • Altered protein mannosylation in developing cerebral cortex by streptomycin.

    abstract::Our research objective was to characterize the biochemical effect of streptomycin during postnatal rat cerebral cortex development using a sensitive method that preserves the in situ topological relationship. We found a decrease in the mannosylation of asparagine-linked oligosaccharides without affecting polypeptide s...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200011090-00033

    authors: Alperin MD,Calandria JM,Carminatti H,Idoyaga-Vargas VP

    更新日期:2000-11-09 00:00:00

  • Expression of melanocortin 1 receptor in periaqueductal gray matter.

    abstract::The localization of the melanocortin 1 (MC1) receptor in brain was investigated by in situ hybridization and immunohistochemistry. In rat periaqueductal gray matter (PAG), a small number of cells which displayed a punctate distribution showed a specific hybridization signal for MC1 receptor mRNA, whereas other regions...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199511000-00022

    authors: Xia Y,Wikberg JE,Chhajlani V

    更新日期:1995-11-13 00:00:00

  • Valproate administration to mice increases hippocampal p21 expression by altering genomic DNA methylation.

    abstract::Although valproate (VPA) is used widely in the treatment of bipolar mood disorder and epilepsy, the precise mechanism of action in the brain remains elusive. In this study, we investigated the effects of subchronic VPA administrations on the expression of the cyclin-dependent kinase inhibitor (Cdkn) family in the hipp...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000000448

    authors: Aizawa S,Yamamuro Y

    更新日期:2015-10-21 00:00:00

  • Developmental expression and localization of KCNJ10 K+ channels in the guinea pig inner ear.

    abstract::The inward rectifier Kir4.1, composed of KCNJ10 K channel subunits, plays an essential role in inner ear K homeostasis. We have investigated the developmental expression and localization of KCNJ10 (Kir4.1) in the guinea pig inner ear using semi-quantitative reverse transcription polymerase chain reaction and immunohis...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/01.wnr.0000208999.25234.91

    authors: Jin Z,Wei D,Järlebark L

    更新日期:2006-04-03 00:00:00

  • Correlation between food intake and CSF IL-1 alpha in anorectic tumor bearing rats.

    abstract::Postulating that central IL-1 is involved in the pathogenesis of cancer anorexia we measured IL-1 alpha in cerebrospinal fluid (CSF) from anorectic tumor bearing (TB) rats and non-tumor bearing controls, and correlated their CSF IL-1 alpha with food intake and tumor weight. Food intake in controls was significantly hi...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199503270-00011

    authors: Opara EI,Laviano A,Meguid MM,Yang ZJ

    更新日期:1995-03-27 00:00:00

  • Nerve cell death induced in vivo by kainic acid and quinolinic acid does not involve apoptosis.

    abstract::We investigated whether in vivo excitotoxicity was mediated by a mechanism of programmed cell death called apoptosis. Neurotoxic doses of kainic acid (1.2 nmol) and quinolinic acid (120 nmol) were unilaterally injected in the dorsal hippocampus of anesthetized rats. Eight or 16 h later the animals were killed and DNA ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199111000-00004

    authors: Ignatowicz E,Vezzani AM,Rizzi M,D'Incalci M

    更新日期:1991-11-01 00:00:00

  • Expression of the neurofibromatosis 1 (NF1) gene in reactive astrocytes in vitro.

    abstract::Neurofibromin, the product of the neurofibromatosis 1 (NF1) gene, is an important tumor suppressor protein expressed most abundantly in the nervous system. Within the central nervous system, neurofibromin has been localized to neurons and oligodendrocytes but not astrocytes. As individuals with NF1 are at an increased...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199507310-00025

    authors: Hewett SJ,Choi DW,Gutmann DH

    更新日期:1995-07-31 00:00:00

  • Hippocampal function and visual object processing in temporal lobe epilepsy.

    abstract::Limbic event-related potentials related to verbal but not to visual recognition memory have been found to be attenuated within the epileptic hippocampus of patients with temporal lobe epilepsy (TLE). To identify hippocampal contributions to visual processing and memory we recorded intracranial ERPs directly from withi...

    journal_title:Neuroreport

    pub_type: 临床试验,杂志文章

    doi:10.1097/00001756-200308060-00017

    authors: Vannucci M,Dietl T,Pezer N,Viggiano MP,Helmstaedter C,Schaller C,Elger CE,Grunwald T

    更新日期:2003-08-06 00:00:00

  • Cholinergic, serotonergic and catecholaminergic neurons are not affected in Ts65Dn mice.

    abstract::Ts65DN mice were developed as a model of Down syndrome (DS); they are trisomic for the distal segment of chromosome 16 (MMU16), which contains genes syntenic with some of the genes located on the critical region of human chromosome 21 (HSA21). Since behavioral and neurochemical disturbances have been observed in this ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199711100-00012

    authors: Megías M,Verduga R,Dierssen M,Flórez J,Insausti R,Crespo D

    更新日期:1997-11-10 00:00:00

  • Sleeping brain, learning brain. The role of sleep for memory systems.

    abstract::The hypothesis that sleep participates in the consolidation of recent memory traces has been investigated using four main paradigms: (1) effects of post-training sleep deprivation on memory consolidation, (2) effects of learning on post-training sleep, (3) effects of within sleep stimulation on the sleep pattern and o...

    journal_title:Neuroreport

    pub_type: 杂志文章,评审

    doi:10.1097/00001756-200112210-00001

    authors: Peigneux P,Laureys S,Delbeuck X,Maquet P

    更新日期:2001-12-21 00:00:00

  • Caffeine-sensitive Ca2+ stores in carp retinal bipolar cells.

    abstract::High K+- or caffeine-induced Ca2+ signal was studied in freshly dissociated carp retinal ON-type bipolar cells using a confocal laser-scanning microscope. In response to 35 mM K+ exposure, a rise in [Ca2+]i appeared in both the terminal and soma, but was absent after removal of external Ca2+ or in the presence of 100 ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199912160-00032

    authors: Wu D,Zhu PH

    更新日期:1999-12-16 00:00:00

  • N-terminal Slit2 promotes survival and neurite extension in cultured peripheral neurons.

    abstract::To investigate the effect of the N-terminal Slit2 protein on neuronal survival and development, recombinant human N-terminal Slit2 (N-Slit2) was assayed against isolated embryonic chick dorsal root ganglion sensory, ciliary ganglion and paravertebral sympathetic neurons. N-Slit2 promoted significant levels of neuronal...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200212030-00041

    authors: Piper M,Nurcombe V,Reid K,Bartlett P,Little M

    更新日期:2002-12-03 00:00:00

  • Decreased neurofilament gene expression is an index of selective axonal hypotrophy in ageing.

    abstract::Axonal atrophy may reflect earlier and more reversible events in neurodegeneration and ageing than somatic atrophy. Innervation density by sympathetic fibres from the rat superior cervical ganglion (SCG) to the middle cerebral artery (MCA) decreases dramatically in old age, while that to the iris is largely unchanged....

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199702100-00044

    authors: Kuchel GA,Poon T,Irshad K,Richard C,Julien JP,Cowen T

    更新日期:1997-02-10 00:00:00

  • Co-localization of PKCepsilon with various GABA(A) receptor subunits in the mouse limbic system.

    abstract::The distribution of PKCepsilon and its co-localization with various GABA(A) receptor subunits within limbic structures of the mouse brain was examined by fluorescence immunohistochemistry. Levels of PKCepsilon immunoreactivity were highest in the cingulate cortex and dentate gyrus, moderate in the nucleus accumbens, a...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200003200-00006

    authors: Olive MF,Hodge CW

    更新日期:2000-03-20 00:00:00

  • Electrophysiological evidence for a two-stage process underlying single chord priming.

    abstract::In this study, we examine through electrophysiological measures three alternative mechanisms underlying musical chord priming: psychoacoustic distance, common parent-key, and distance along the circle of fifths. In contrast with previous behavioral studies, we present complex tones which do not blur the melodic compon...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e32832bfcaf

    authors: Granot RY,Hai A

    更新日期:2009-06-17 00:00:00