Mesolimbic gender differences in peptide CART mRNA expression: effects of cocaine.

Abstract:

:The putative neurotransmitter peptide CART has been suggested to be involved in the actions of psychostimulants. We analyzed the CART mRNA expression in mesolimbic brain areas of male and ovariectomized 17beta-estradiol- (30 microg) and vehicle-treated female rats. A gender difference was noted in the accumbens shell during basal conditions; male rats expressed higher levels of CART mRNA than both female groups. Following binge cocaine injections (3 x 15 mg/kg), elevated levels were found in the central amygdala of male but not female rats. In the medial accumbens shell CART mRNA was elevated after cocaine, but only in the non-treated females. The present results support a role of mesolimbic CART in psychostimulant drug action.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Fagergren P,Hurd YL

doi

10.1097/00001756-199911080-00034

subject

Has Abstract

pub_date

1999-11-08 00:00:00

pages

3449-52

issue

16

eissn

0959-4965

issn

1473-558X

journal_volume

10

pub_type

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