Abstract:
:The putative neurotransmitter peptide CART has been suggested to be involved in the actions of psychostimulants. We analyzed the CART mRNA expression in mesolimbic brain areas of male and ovariectomized 17beta-estradiol- (30 microg) and vehicle-treated female rats. A gender difference was noted in the accumbens shell during basal conditions; male rats expressed higher levels of CART mRNA than both female groups. Following binge cocaine injections (3 x 15 mg/kg), elevated levels were found in the central amygdala of male but not female rats. In the medial accumbens shell CART mRNA was elevated after cocaine, but only in the non-treated females. The present results support a role of mesolimbic CART in psychostimulant drug action.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Fagergren P,Hurd YLdoi
10.1097/00001756-199911080-00034subject
Has Abstractpub_date
1999-11-08 00:00:00pages
3449-52issue
16eissn
0959-4965issn
1473-558Xjournal_volume
10pub_type
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