Abstract:
:Glutamatergic excitotoxicity has been implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS). However, activation of metabotropic glutamate receptors (mGluRs) is neuroprotective in several paradigms. We therefore tested the effect of selective mGluR agonists on cultured chick embryonic motor neurons. Activation of group I mGluRs with (s)-3,5-dihydroxyphenylglycine (DHPG) and group III mGluRs with L-2-amino-4-phosphono-butanoate (L-AP4) promoted a modest but significant, dose-dependent delay of apoptosis, which could be blocked by specific mGluR antagonists. Group II or selective mGluR5 stimulations were ineffective. Correspondingly, in situ hybridization experiments showed only expression of mGluR1 (group I) and mGluR4 and 7 (group III) in human motor neurons. Dissection of the pathways involved in this survival effect may help to elucidate the pathogenesis of ALS.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Anneser JM,Horstmann S,Weydt P,Borasio GDdoi
10.1097/00001756-199806220-00024subject
Has Abstractpub_date
1998-06-22 00:00:00pages
2039-43issue
9eissn
0959-4965issn
1473-558Xjournal_volume
9pub_type
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