Sex-related suppression of reflex jaw muscle activity by peripheral morphine but not GABA.

Abstract:

:The present study examined the effect of peripherally applied morphine and GABA on jaw muscle electromyographic activity reflexly evoked by co-injection of glutamate into the temporomandibular joint (TMJ) of lightly anesthetized Sprague-Dawley rats of both sexes. In male but not female rats, morphine significantly suppressed glutamate-evoked jaw muscle activity in a dose-dependent and naloxone-reversible manner. The median suppressive dose (+/- s.e.) for male rats was 12.7 +/- 3.1 microg (digastric muscle) and 12.6 +/- 1.3 microg (masseter muscle). GABA (5 micromol) significantly reduced glutamate-evoked muscle activity in both sexes. These data suggest that female rats are considerably less sensitive than male rats to the suppressive effects of peripherally applied morphine, but both sexes are equally affected by peripherally applied GABA.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Cai BB,Cairns BE,Sessle BJ,Hu JW

doi

10.1097/00001756-200111160-00016

subject

Has Abstract

pub_date

2001-11-16 00:00:00

pages

3457-60

issue

16

eissn

0959-4965

issn

1473-558X

journal_volume

12

pub_type

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