Abstract:
:Prior research with rodent models, performed predominantly in males, has demonstrated a significant association between focal neocortical malformations (e.g. ectopias and microgyria) and rate-specific auditory processing deficits. In the current study and consistent with prior findings, we report that ectopic male BXSB/MpJ mice exhibit impairments in detecting a two-tone oddball stimulus at short but not long inter-stimulus interval durations when compared to non-ectopic male littermates. However, ectopic female littermates showed no rapid auditory processing deficit when compared to non-ectopic females on this same task. Current results add growing support to: (1) an association between focal cortical malformations and impaired auditory processing in males; and (2) the existence of sex differences in the behavioral consequences of focal cortical malformations.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Peiffer AM,Rosen GD,Fitch RHdoi
10.1097/00001756-200212030-00021subject
Has Abstractpub_date
2002-12-03 00:00:00pages
2277-80issue
17eissn
0959-4965issn
1473-558Xjournal_volume
13pub_type
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