Abstract:
:Proteins of the postsynaptic density are implicated in mechanisms of synaptic plasticity. We examined involvement of PSD95 and alphaCaMkII in learning-dependent plastic changes of representational maps in somatosensory cortex of mice. The barrel cortex of mice was examined following a 3 day long classical conditioning training, in which activation of facial vibrissae was linked to an aversive stimulus. This procedure produced expansion of cortical representations of vibrissae involved in the training. In subcellular fraction enriched in postsynaptic densities from the barrel cortex, it was estimated by Western blotting that the level of PSD95 increased after the training by about 50%, while the level of CaMkII remained unchanged. The results indicate involvement of PSD95 in learning-dependent cortical plasticity.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Skibinska A,Lech M,Kossut Mdoi
10.1097/00001756-200109170-00030subject
Has Abstractpub_date
2001-09-17 00:00:00pages
2907-10issue
13eissn
0959-4965issn
1473-558Xjournal_volume
12pub_type
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