PSD95 protein level rises in murine somatosensory cortex after sensory training.

Abstract:

:Proteins of the postsynaptic density are implicated in mechanisms of synaptic plasticity. We examined involvement of PSD95 and alphaCaMkII in learning-dependent plastic changes of representational maps in somatosensory cortex of mice. The barrel cortex of mice was examined following a 3 day long classical conditioning training, in which activation of facial vibrissae was linked to an aversive stimulus. This procedure produced expansion of cortical representations of vibrissae involved in the training. In subcellular fraction enriched in postsynaptic densities from the barrel cortex, it was estimated by Western blotting that the level of PSD95 increased after the training by about 50%, while the level of CaMkII remained unchanged. The results indicate involvement of PSD95 in learning-dependent cortical plasticity.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Skibinska A,Lech M,Kossut M

doi

10.1097/00001756-200109170-00030

subject

Has Abstract

pub_date

2001-09-17 00:00:00

pages

2907-10

issue

13

eissn

0959-4965

issn

1473-558X

journal_volume

12

pub_type

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