Abstract:
:We show that the pro-apoptotic proteins Bax and Bak trigger apoptosis when over-expressed in sympathetic neurons cultured in the presence of NGF. This effect can be blocked with z-VAD-fmk, a peptide inhibitor of caspases, but not with anti-apoptotic chemical compounds such as antioxidants or proteasome inhibitors. These results demonstrate that in sympathetic neurons Bax and Bak are sufficient to induce apoptosis in the absence of any other apparent cell death stimulus and that their effect is mediated by caspases but does not require reactive oxygen species nor activity of the proteasome.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Martinou I,Missotten M,Fernandez PA,Sadoul R,Martinou JCdoi
10.1097/00001756-199801050-00004subject
Has Abstractpub_date
1998-01-05 00:00:00pages
15-9issue
1eissn
0959-4965issn
1473-558Xjournal_volume
9pub_type
杂志文章相关文献
NEUROREPORT文献大全abstract::Acute mitochondrial dysfunction in the cochlea is likely to result in hearing loss as a consequence of local energy shortage, similar to ischemia- or noise-induced hearing loss. To establish an animal model of acute cochlear mitochondrial dysfunction, we applied a mitochondrial toxin, 3-nitropropionic acid (3-NP) in t...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000133226.94662.80
更新日期:2004-07-19 00:00:00
abstract::Previous studies suggest that there is a dopamine lowering process during major depressive episodes (MDE). To investigate this, we measured the dopamine transporter binding potential (DAT BP) in the striatum of depressed and healthy subjects using [(11)C]RTI-32 PET. The DAT, a predominantly presynaptic receptor, decre...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200112210-00052
更新日期:2001-12-21 00:00:00
abstract::The aim was to study the effects of an NMDA receptor antagonist on caspase-3 activation and DNA fragmentation after hypoxia-ischemia (HI) in 7-day-old rats. Animals were treated with vehicle or MK-801 (0.5 mg/kg) directly after HI and sacrificed 8, 24 or 72h later. MK-801 reduced injury (by 53%), cells positive for ac...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200009110-00002
更新日期:2000-09-11 00:00:00
abstract::The trans-sialidase (TS) of Trypanosoma cruzi induces survival and differentiation of neuronal and glial cells. This mechanism underlying survival is via phosphatidylinositol 3-kinase (PI3K) but how TS promotes neuronal differentiation remained to be determined. Here we show that TS-induced neurite outgrowth in PC12 c...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200112040-00022
更新日期:2001-12-04 00:00:00
abstract::This report describes neurogenesis in the adult human olfactory epithelium in vitro. Olfactory epithelium was collected at autopsy and by biopsy, and grown in serum-free medium. Basic fibroblast growth factor induced the differentiation of bipolar cells which were immunopositive for several neuronal proteins but not g...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199604260-00019
更新日期:1996-04-26 00:00:00
abstract::Deficits of working memory (WM) are recognized as an important pathological feature in schizophrenia. Since the P600 component of event related potentials has been hypothesized that represents aspects of second-pass parsing processes of information processing, and is related to WM, the present study focuses on P600 el...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200109170-00010
更新日期:2001-09-17 00:00:00
abstract::The L1/NgCAM cell adhesion molecule is involved in neurite outgrowth, axonal fasciculation and cell migration in the nervous system. We studied the effects of antibodies against L1 injected intracranially at various times before and after training 2-day-old chicks in a visual categorization task. Memory retention was ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199805110-00070
更新日期:1998-05-11 00:00:00
abstract::Blood oxygen level dependent MRI was used to test whether cocaine-stimulated mesolimbic activity varied with sexual receptivity. Rats were randomly screened for lordotic responses and were then imaged for their responses to centrally administered cocaine. We observed that female rats expressing no lordosis showed a gr...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3283416f81
更新日期:2011-01-05 00:00:00
abstract::Magnetic brain responses were recorded to clarify the cortical representation of vowel processing in Japanese. We investigated the peak latencies and equivalent current dipoles of the auditory N1m responses to the Japanese vowels [a], [i], [o], and [u]. In intraindividual analyses for a single participant, well-replic...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000230503.47973.b7
更新日期:2006-07-31 00:00:00
abstract::Aging and Alzheimer's disease (AD) are both characterized by memory impairments and sleep changes. We investigated the potential link between these disturbances, focusing on sleep spindles, involved in memory consolidation. Two episodic memory tasks were given to young and old healthy participants, as well as to AD pa...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32830867c4
更新日期:2008-07-16 00:00:00
abstract::The effects of high frequency repetitive transcranial magnetic stimulation on sensory perception and the pain tolerance thresholds were investigated applying both motor cortex stimulation and medial frontal cortex stimulation in normal study participants. Both the sensory perception and pain tolerance thresholds were ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000198438.37012.d6
更新日期:2006-02-06 00:00:00
abstract::In an attempt to determine whether small focal malformations of the neocortex can be visualized in vivo, focal microgyria were induced in the neocortex of otherwise normal rats by freezing injury to the developing cortical plate, and in adulthood the malformation was visualized using MRI. Induced microgyria of varying...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199712220-00009
更新日期:1997-12-22 00:00:00
abstract::Timing of the mammalian circadian clock of the suprachiasmatic nucleus (SCN) is regulated by photic input from the retina. Retinorecipient units entrain rhythmicity of SCN pacemaker cells in part through their release of vasoactive intestinal polypeptide (VIP). The underlying nature of this process is conjectural, how...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32833fcba4
更新日期:2010-11-17 00:00:00
abstract::Previous studies have indicated that estrogen protects the brain from ischemic damage and regulates K(ATP) channel activity; the present study was designed to address the involvement of K(ATP) channels in the neuroprotective effects of estrogen in focal cerebral ischemia: in experiment 1, K(ATP) mRNA and protein in th...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3283598de6
更新日期:2012-11-14 00:00:00
abstract::To determine whether EEG synchronization in sleep has a metabolic equivalent, we investigated state-dependent changes in extracellular concentrations of amino acids. In vivo microdialysis studies were performed in the ventroposterolateral (VPL) nuclei of the thalamus of cats during natural slow wave sleep (SWS), wakin...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199703240-00025
更新日期:1997-03-24 00:00:00
abstract::The objective of this study was to investigate the effects of long-term mental abacus calculation training (MACT) on children's spatial attention orientation. Fifteen children with intensive MACT (MACT group) and 15 children without MACT (non-MACT group) were selected. The two groups of children were matched in age, s...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000705
更新日期:2017-01-01 00:00:00
abstract::In Xenopus oocytes coinjected with poly(A)+ RNA derived from the rat cerebellum and cRNAs for the cloned G protein-gated inwardly rectifying K+ channel (GIRK), GIRK1 and GIRK2, the GABA-B agonist baclofen elicited inwardly rectifying K+ currents. The inward K+ currents elicited by baclofen were inhibited by the select...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199803090-00004
更新日期:1998-03-09 00:00:00
abstract::Recent experiments have suggested that the process of visuomotor adaptation depends on how a visual distortion is introduced. The cerebellum is thought to be involved in adapting to rapidly introduced visual distortions; however its role in adapting to a gradually introduced distortion is unknown. We tested adaptation...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199904060-00025
更新日期:1999-04-06 00:00:00
abstract::Optical imaging of rat barrel cortex has provided detailed spatio-temporal maps of functional cortical architecture. We describe an event-related procedure (ERP) for optical imaging based on selective signal averaging as reported by Burock et al., using an anti-correlative pseudo-random event sequence. The sequence us...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200007140-00037
更新日期:2000-07-14 00:00:00
abstract::A polymorphism of the apolipoprotein E gene, in particular the epsilon 4 allele (ApoE4), has been associated with impaired neuronal phospholipid metabolism and synapse reorganization and has been implicated in several neurodegenerative disorders. Since selective neuronal cell lose and aberrant axonal reorganization re...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199703240-00035
更新日期:1997-03-24 00:00:00
abstract::Alopecia areata (AA) is a dermatosis involving the sudden occurrence of bald patches on the scalp. Although the aetiology is unknown, experimental data indicate that cutaneous microcirculation plays an important role. The skin is richly innervated by neuropeptidergic sensory nerves that help regulate microvascular cir...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199703240-00015
更新日期:1997-03-24 00:00:00
abstract::To investigate the neural substrates for the perception of motion and of position in depth, we examined the changes in regional cerebral blood flow during positional and motion stereopsis in humans by positron emission tomography. During positional stereopsis, the right striate and peristriate cortices (areas V1/V2 an...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199607290-00004
更新日期:1996-07-29 00:00:00
abstract::Impaired print tuning in dyslexia has been shown in alphabetic languages; whether we can observe the same in a nonalphabetic language such as Chinese is still questionable. The present study investigated the N170 component in response to Chinese words versus nonword pseudo-words in 10-year-old children with developmen...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001080
更新日期:2018-10-17 00:00:00
abstract::Limbic event-related potentials related to verbal but not to visual recognition memory have been found to be attenuated within the epileptic hippocampus of patients with temporal lobe epilepsy (TLE). To identify hippocampal contributions to visual processing and memory we recorded intracranial ERPs directly from withi...
journal_title:Neuroreport
pub_type: 临床试验,杂志文章
doi:10.1097/00001756-200308060-00017
更新日期:2003-08-06 00:00:00
abstract::In the present study we tested the hypothesis that baclofen, a GABA-B receptor agonist, attenuates methamphetamine self-administration. Fifteen rats were trained to self-administer i.v. injections of methamphetamine (0, 0.0625, 0.125 and 0.25 mg/kg/injection) on a progressive ratio schedule of reinforcement, and then ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200207020-00007
更新日期:2002-07-02 00:00:00
abstract::Histamine-related drugs are commonly used in the treatment of vertigo and related vestibular disorders. Their site and mechanism of action, however, are still poorly understood. To increase our knowledge of the histaminergic system in the vestibular organs, we have investigated the expression of H1 and H3 histamine re...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3282f76151
更新日期:2008-03-05 00:00:00
abstract::Nerve growth factor (NGF) is trophic to sensory and sympathetic fibres, and ciliary neurotrophic factor (CNTF) to motoneurones, in animal models of peripheral nerve injury: NGF excess produces hyperalgesia. In this first study of injured human nerves and sensory ganglia, we quantified and localized endogenous NGF and ...
journal_title:Neuroreport
pub_type: 临床试验,杂志文章
doi:10.1097/00001756-199705260-00028
更新日期:1997-05-27 00:00:00
abstract::Peripheral sensorineural hearing loss is a very common inner ear disorder affecting nearly 10% of the population. At present there is no cure for this disorder but gene therapy has been suggested as a potentially effective method for clinical treatment in the future. Thus we investigated the effectiveness of adenovira...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200207190-00016
更新日期:2002-07-19 00:00:00
abstract::Previous studies in adult rats have demonstrated that the neurotrophin, brain-derived neurotrophic factor (BDNF), is present in virtually all cells of the pituitary intermediate lobe. In the present study, we demonstrate that cells cultured from adult intermediate lobe pituitary (ILP) rapidly lose their BDNF immunorea...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199703240-00005
更新日期:1997-03-24 00:00:00
abstract::We investigated the role of kainate receptor activation in modulating the influx of Ca2+ coupled to the exocytotic release of glutamate in rat hippocampal synaptosomal fractions (P2). In whole hippocampus synaptosomes stimulation with domoic acid increased the intracellular free Ca2+ concentration ([Ca2+]i) in a dose-...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199605170-00023
更新日期:1996-05-17 00:00:00