Abstract:
:In an attempt to determine whether small focal malformations of the neocortex can be visualized in vivo, focal microgyria were induced in the neocortex of otherwise normal rats by freezing injury to the developing cortical plate, and in adulthood the malformation was visualized using MRI. Induced microgyria of varying size were successfully visualized with MRI, and the location and extent of the malformation was confirmed on subsequent histology. This work has potential implications for the field of experimental neuropathology by enhancing the ability to study the behavioral and connectional consequences of these malformations in animals. In addition, this work points toward future research for the in vivo visualization of these small, focal malformations in humans.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Rosen GD,Burstein Ddoi
10.1097/00001756-199712220-00009subject
Has Abstractpub_date
1997-12-22 00:00:00pages
3883-7issue
18eissn
0959-4965issn
1473-558Xjournal_volume
8pub_type
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