BOLD signal response to cocaine varies with sexual receptivity in female rats.

Abstract:

:Blood oxygen level dependent MRI was used to test whether cocaine-stimulated mesolimbic activity varied with sexual receptivity. Rats were randomly screened for lordotic responses and were then imaged for their responses to centrally administered cocaine. We observed that female rats expressing no lordosis showed a greater activation of mesolimbic and nigrostriatal structures than lordotic female rats. Our data suggest that the differential sensitivity to cocaine occurs not only as a result of hormonal changes of the estrous cycle, but also in association with changes in sexual receptivity.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Febo M,Segarra AC,Stolberg TL,Ferris CF

doi

10.1097/WNR.0b013e3283416f81

subject

Has Abstract

pub_date

2011-01-05 00:00:00

pages

19-22

issue

1

eissn

0959-4965

issn

1473-558X

journal_volume

22

pub_type

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