Abstract:
:ONO-1714, a selective inhibitor of inducible nitric oxide synthetase (iNOS) attenuated the increase of apoptosis and improved the functional outcome of urinary bladder after traumatic spinal cord injury. These findings suggest that iNOS plays a role in the process of SCI. Early treatment with 30 mg/kg methylprednisolone sodium succinate (MPSS) could also inhibit the expression of iNOS gene, apoptosis and the loss of urinary bladder function. We confirmed that early MPSS treatment may prevent injury associated with apoptosis and urinary bladder disability by reducing iNOS mRNA. However, delayed single MPSS treatment 8 h after spinal cord injury was not effective. Early repeated MPSS treatment might allow greater recovery from acute spinal cord injury.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Yu Y,Matsuyama Y,Nakashima S,Yanase M,Kiuchi K,Ishiguro Ndoi
10.1097/00001756-200409150-00021subject
Has Abstractpub_date
2004-09-15 00:00:00pages
2103-7issue
13eissn
0959-4965issn
1473-558Xpii
00001756-200409150-00021journal_volume
15pub_type
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