Effects of MPSS and a potent iNOS inhibitor on traumatic spinal cord injury.

Abstract:

:ONO-1714, a selective inhibitor of inducible nitric oxide synthetase (iNOS) attenuated the increase of apoptosis and improved the functional outcome of urinary bladder after traumatic spinal cord injury. These findings suggest that iNOS plays a role in the process of SCI. Early treatment with 30 mg/kg methylprednisolone sodium succinate (MPSS) could also inhibit the expression of iNOS gene, apoptosis and the loss of urinary bladder function. We confirmed that early MPSS treatment may prevent injury associated with apoptosis and urinary bladder disability by reducing iNOS mRNA. However, delayed single MPSS treatment 8 h after spinal cord injury was not effective. Early repeated MPSS treatment might allow greater recovery from acute spinal cord injury.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Yu Y,Matsuyama Y,Nakashima S,Yanase M,Kiuchi K,Ishiguro N

doi

10.1097/00001756-200409150-00021

subject

Has Abstract

pub_date

2004-09-15 00:00:00

pages

2103-7

issue

13

eissn

0959-4965

issn

1473-558X

pii

00001756-200409150-00021

journal_volume

15

pub_type

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