Abstract:
:In situ hybridization has demonstrated mRNA for olfactory receptors (OR) in the axon terminals of olfactory receptor neurons. Neurons that express the same OR appear to send their axons to two stereotyped glomeruli in the olfactory bulb (OB). Based on these observations, we tested the feasibility of using RT-PCR to isolate and sequence OR mRNA from small samples of the rat OB glomerular layer. Biomagnetic mRNA isolation followed by RT-PCR yielded partial sequences for 21 novel members of the OR family. The results suggest that the topography of OR mRNA can be mapped across the OB, to study synaptic specificity and odor representation in the olfactory system.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Singer MS,Hughes TE,Shepherd GM,Greer CAdoi
10.1097/00001756-199811160-00032subject
Has Abstractpub_date
1998-11-16 00:00:00pages
3745-8issue
16eissn
0959-4965issn
1473-558Xjournal_volume
9pub_type
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