Region-specific expression of cell cycle inhibitors in the adult brain.

abstract：:Event-related brain potentials were examined in 6 to 8-year-old children with primary language disorder before and after a 5-week narrative-based language intervention. Participants listened to sentences ending with semantically congruous or incongruous words. By comparison with typical controls, the children with pri...

journal_title：Neuroreport

authors： Popescu M,Fey ME,Lewine JD,Finestack LH,Popescu EA

更新日期：2009-08-05 00:00:00

abstract：:Neuroimaging evidence suggests that human Brodmann area 5 (BA5) within the superior parietal lobule contributes to movement planning. However, a causal role for the contribution of BA5 to preparatory processes has yet to be reported. We used paired-pulse transcranial magnetic stimulation to investigate the influence o...

journal_title：Neuroreport

authors： Mackenzie TN,Bailey AZ,Mi PY,Tsang P,Jones CB,Nelson AJ

更新日期：2016-09-28 00:00:00

abstract：:We investigated the influence of noise on brain responses to spoken sentences in MEG. Sixteen subjects had to listen to acoustically presented sentences and judge their syntactic correctness. Sentences were either presented on a silent background or with noise. Noise had differential effects on early auditory and synt...

journal_title：Neuroreport

authors： Herrmann CS,Oertel U,Wang Y,Maess B,Friederici AD

更新日期：2000-02-07 00:00:00

abstract：:Voltage-dependent outward currents were examined in CA1 neurones by whole-cell recording in slices. Nine cells were recorded with the 'standard' internal solution (KMeSO4, HEPES, EGTA, CaCl2, and MgCl2) and held a potential (-54 +/- 3 mV) at which there was no significant outward current. Cromakalim (CROM, 100 microM)...

journal_title：Neuroreport

authors： Erdemli G,Krnjević K

更新日期：1994-06-27 00:00:00

abstract：:Methylphenidate (Ritalin) is a psychostimulant drug used to treat children with attention deficit hyperactivity disorder. Despite its widespread and increasing clinical use, little is known about the long-term consequences of drug treatment. We compared the effects of a single injection of methylphenidate with that of...

journal_title：Neuroreport

authors： Chase TD,Brown RE,Carrey N,Wilkinson M

更新日期：2003-04-15 00:00:00

abstract：:Effects of adrenalectomy on the 5-HT1A receptor agonist 8-hydroxy-2-di-n-(propylamino)tetralin (8-OH-DPAT)- and 2-deoxy-D-glucose (2-DG)-induced hyperphagia were investigated in rats. Prior adrenalectomy completely inhibited 2-DG-induced hyperphagia, although it did not affect increases in food intake elicited by 8-OH...

journal_title：Neuroreport

authors： Yamada J,Sugimoto Y,Yoshikawa T

更新日期：1998-06-01 00:00:00

abstract：:Matrix metalloproteinase-9 (MMP-9) and its specific inhibitor, tissue inhibitor of matrix metalloproteinase-1 (TIMP-1), were analysed by enzyme-linked immunosorbent assay (ELISA) and by zymography in serum and cerebrospinal fluid (CSF) of patients with amyotrophic lateral sclerosis (ALS). In contrast to patients with ...

journal_title：Neuroreport

authors： Beuche W,Yushchenko M,Mäder M,Maliszewska M,Felgenhauer K,Weber F

更新日期：2000-11-09 00:00:00

abstract：:Predicting neuron death or survival after axonal injury is important in neurotrauma research. We now used in vivo confocal neuroimaging microscopy to repeatedly visualize retinal ganglion cells after optic nerve crush and studied their morphological alterations and ultimate fate. An intracollicular injection of a retr...

journal_title：Neuroreport

authors： Rousseau V,Engelmann R,Sabel BA

更新日期：1999-11-08 00:00:00

abstract：:The neurotrophin-inducible gene VGF plays an important role in the maintenance of organismal energy balance and in the mediation of hippocampal synaptic activity. The regulatory mechanism of VGF transcription is not fully understood. The neuron-restrictive silencer factor (NRSF) binds with the neuron-restrictive silen...

journal_title：Neuroreport

authors： Moon SM,Kim JS,Park BR,Kim DK,Kim SG,Kim HJ,Chun HS,Lee BK,Kim CS

更新日期：2015-02-11 00:00:00

abstract：:Event-related potentials were recorded in healthy volunteers to test the accuracy of the human brain to extract, preattentively, auditory abstract rules. The abstract rule was determined by the frequency relationship between two pure tones forming a pair. The standard pairs had identical tone frequency, whereas the de...

journal_title：Neuroreport

authors： Carral V,Corral MJ,Escera C

更新日期：2005-02-28 00:00:00

abstract：:We studied whether pro-survival Akt was activated after transient focal cerebral ischemia and whether it inhibited pro-apoptotic Bad. Phosphorylation of Akt (serine-473) was enhanced in cortex after 1-hour ischemia, and also after 1h and 6 h of reperfusion, but it returned back to that in controls by 24 h. After this ...

journal_title：Neuroreport

authors： Friguls B,Justicia C,Pallàs M,Planas AM

更新日期：2001-10-29 00:00:00

abstract：:The NMDA receptor is one of the ionotropic glutamate receptors essential for excitatory neurotransmission. The NMDAR1 subunit is inactivated by direct interaction with calmodulin. The protein levels of calmodulin, NMDAR1 and their complex were quantified in tissue resected from epileptogenic and non-epileptogenic cort...

journal_title：Neuroreport

authors： Mikuni N,Nishiyama K,Babb TL,Ying Z,Najm I,Okamoto T,Lüders HO,Wylie C

更新日期：1999-05-14 00:00:00

abstract：:Substantial evidence suggests a negative association between cigarette smoking and the incidence and severity of ulcerative colitis, a common human inflammatory bowel disease. Nicotine has been implicated in this association. The detection of nicotinic acetylcholine receptors in colonic epithelium, the primary tissue ...

journal_title：Neuroreport

authors： Orr-Urtreger A,Kedmi M,Rosner S,Karmeli F,Rachmilewitz D

更新日期：2005-07-13 00:00:00

abstract：:This study examined the effects of cocaine HCl and ambient temperature on the core body temperature of the rat. To further examine the mechanisms of cocaine-induced changes in temperature regulation, the effects of cocaine on behavioral thermoregulatory responses were also observed. At normal room temperature (20 degr...

journal_title：Neuroreport

authors： Gonzalez LP

更新日期：1993-01-01 00:00:00

abstract：:GLAST is a glial glutamate transporter; mRNA for a splice variant, GLAST1a, which lacks exon 3, has previously been identified. To detect GLAST1a protein, we generated antibodies against a peptide sequence encompassing the splice site. We demonstrate by Western blotting and immunocytochemistry the expression of GLAST1...

journal_title：Neuroreport

authors： Macnab LT,Williams SM,Pow DV

更新日期：2006-12-18 00:00:00

abstract：:Perception of apparent motion operates somewhat differently for objects and human figures. Depending on the interstimulus interval, the latter d may give rise to either perception of a direct path (i.e. biologically impossible) or indirect path (i.e. biologically possible). Here, PET was used to investigate whether a ...

journal_title：Neuroreport

authors： Stevens JA,Fonlupt P,Shiffrar M,Decety J

更新日期：2000-01-17 00:00:00

abstract：:The mechanisms underlying the expression of long-term synaptic potentiation (LTP) in the lateral and medial perforant path inputs to the dentate gyrus were examined in pentobarbital anaesthetized rats. Lateral path LTP was accompanied by a robust, long-lasting reduction in lateral path paired-pulse facilitation (PPF)....

journal_title：Neuroreport

authors： Christie BR,Abraham WC

更新日期：1994-01-12 00:00:00

abstract：:The present study examines whether or not prolactin-releasing peptide (PrRP) infused intracerebroventricularly (i.c.v.) affects sleep and the release of prolactin (PRL) and growth hormone (GH) in rats. At a dose of 0.1 nmol, PrRP promoted rapid-eye-movement (REM) sleep, whereas 1.0 nmol increased both non-REM and REM ...

journal_title：Neuroreport

authors： Zhang SQ,Inoué S,Kimura M

更新日期：2001-10-29 00:00:00

abstract：:The present study aims to study sequential alterations occurring in both dopaminergic neurons and microglia in substantia nigra (SN) following intrastriatal injection of 1-methyl-4-phenylpridium ion (MPP+) in rats. Heme oxygenase-1 (HO-1), a marker of oxidative stress, first appeared in dopaminergic neurons in SN at 1...

journal_title：Neuroreport

authors： Miwa H,Kubo T,Morita S,Nakanishi I,Kondo T

更新日期：2004-04-29 00:00:00

abstract：:Densities of serotonin transporters (5-HTT) in the postmortem neocortex of behaviorally assessed Alzheimer's disease (AD) patients and aged controls were measured by radioligand binding with [3H]citalopram. It was found that 5-HTT sites in the temporal cortex of AD patients with prominent antemortem anxiety were unalt...

journal_title：Neuroreport

authors： Tsang SW,Lai MK,Francis PT,Wong PT,Spence I,Esiri MM,Keene J,Hope T,Chen CP

更新日期：2003-07-18 00:00:00

abstract：:Timing of the mammalian circadian clock of the suprachiasmatic nucleus (SCN) is regulated by photic input from the retina. Retinorecipient units entrain rhythmicity of SCN pacemaker cells in part through their release of vasoactive intestinal polypeptide (VIP). The underlying nature of this process is conjectural, how...

journal_title：Neuroreport

authors： Francl JM,Kaur G,Glass JD

更新日期：2010-11-17 00:00:00

abstract：:Duchenne muscular dystrophy is due to mutations in the dystrophin gene which is predominantly expressed in muscle and brain. Since the disease is associated with cognitive impairment, we sought to localize dystrophin mRNA in brain using in situ hybridization with oligonucleotide probes. We find the gene strongly expre...

journal_title：Neuroreport

authors： Gorecki D,Geng Y,Thomas K,Hunt SP,Barnard EA,Barnard PJ

更新日期：1991-12-01 00:00:00

abstract：:The neuroprotective effect of docosahexaenoic acid (DHA) on the glutamate-induced cytotoxicity in rat hippocampal cultures was investigated in the present study. DHA at 5-50 microg/ml successfully protected neurons against the cytotoxicity, markedly increased the cell viability, inhibited both nitric oxide (NO) produc...

journal_title：Neuroreport

authors： Wang X,Zhao X,Mao ZY,Wang XM,Liu ZL

更新日期：2003-12-19 00:00:00

abstract：:In Xenopus oocytes coinjected with poly(A)+ RNA derived from the rat cerebellum and cRNAs for the cloned G protein-gated inwardly rectifying K+ channel (GIRK), GIRK1 and GIRK2, the GABA-B agonist baclofen elicited inwardly rectifying K+ currents. The inward K+ currents elicited by baclofen were inhibited by the select...

journal_title：Neuroreport

authors： Uezono Y,Akihara M,Kaibara M,Kawano C,Shibuya I,Ueda Y,Yanagihara N,Toyohira Y,Yamashita H,Taniyama K,Izumi F

更新日期：1998-03-09 00:00:00

abstract：:The distribution of GABA(B) receptor subunits GABA(B(1a)), GABA(B(1b)) and GABA(B2), has been examined in the cerebral cortex and thalamus of adult rats using an immunocytochemical technique. GABA(B(1a)) and GABA(B(1b)) subunits co-localized with GABA(B2) in the cortex, where afferent thalamic GABAergic axons project ...

journal_title：Neuroreport

authors： Princivalle AP,Pangalos MN,Bowery NG,Spreafico R

更新日期：2001-03-05 00:00:00

abstract：:Dysfunction of the cholinergic system of the basal forebrain complex is one of the major contributors toward cognitive impairment in Alzheimer's disease (AD). In AD, degeneration of cholinergic fibers that project to the cerebral cortex and hippocampus may be attributed to the development of neurofibrillary tangles (N...

journal_title：Neuroreport

authors： Kim JM,Kim SS,Lee YD

更新日期：2015-09-09 00:00:00

abstract：:Abnormal sleep architecture and white matter hyperintensities (WMHs) may be involved in cognitive impairment. There is little evidence on the connections between WMHs and chronic insomnia disorder (CID). Therefore, we evaluated the severity of WMHs and polysomnography parameters as well as cognitive tests to explore t...

journal_title：Neuroreport

authors： Lu S,Song L,Wang D,Zhang X,Lv X,Yin H,Gao Y,Liu X,Tang J

更新日期：2019-06-12 00:00:00

abstract：:Recently it has been reported that a missense G(88)C mutation within exon 3 and a missense G(209)A mutation within exon 4 of the alpha-synuclein gene were linked to familial Parkinson's Disease (PD). We decided to investigate if these and any other mutations in exons 3 and 4 of the alpha-synuclein gene could be detect...

journal_title：Neuroreport

authors： El-Agnaf OM,Curran MD,Wallace A,Middleton D,Murgatroyd C,Curtis A,Perry R,Jaros E

更新日期：1998-12-01 00:00:00

abstract：:The present study examined the effects of cocaine-regulated and amphetamine-regulated transcript peptide (CARTp) fragment 55-102, on N-methyl-D-aspartate (NMDA)-mediated nociceptive transmission in vivo and in vitro. In-vivo experiments were conducted in Sprague-Dawley rats to evaluate the effects of CARTp on thermal ...

journal_title：Neuroreport

authors： Hsun Lin H,Chiu HY,Lai CC

更新日期：2005-02-28 00:00:00

abstract：:Two groups of hemiparkinsonian rats received grafts of embryonic ventral mesencephalon with or without the addition of the NMDA receptor antagonist (+)dizocilpine hydrogen maleate (MK-801). When added to the cell suspension, a 10 microM concentration of MK-801 did not enhance the survival of tyrosine hydroxylase posit...

journal_title：Neuroreport

authors： Schierle GS,Karlsson J,Brundin P

更新日期：1998-05-11 00:00:00