Abstract:
:Predicting neuron death or survival after axonal injury is important in neurotrauma research. We now used in vivo confocal neuroimaging microscopy to repeatedly visualize retinal ganglion cells after optic nerve crush and studied their morphological alterations and ultimate fate. An intracollicular injection of a retrograde fluorescent tracer was made before or after optic nerve crush. Retinal ganglion cell sizes were then determined at different time points up to post-surgery day 75. Cell death was inevitable when soma swelling was fast and massive (86% above baseline or higher), but when it was slower and moderate (32% above baseline) long-term neuron survival could be predicted with high accuracy as early as post-operative day 5. Moderate swelling continued until day 15 (64%) and after about 3 weeks these cells started shrinking again, as a sign of recovery. We propose that moderate soma swelling is an adaptive rather than pathogenic post-traumatic reaction to axonal injury.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Rousseau V,Engelmann R,Sabel BAdoi
10.1097/00001756-199911080-00024subject
Has Abstractpub_date
1999-11-08 00:00:00pages
3387-91issue
16eissn
0959-4965issn
1473-558Xjournal_volume
10pub_type
杂志文章相关文献
NEUROREPORT文献大全abstract::We evaluated the effects of chemical lesions on hindpaw inflammation-induced Fos protein expression in spinoparabrachial neurons that were retrogradely labeled by Fluoro-Gold. The descending serotoninergic and noradrenergic pathways were destroyed by the selective neurotoxins, 5,7-DHT and DSP-4, respectively. After 5,...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199906030-00024
更新日期:1999-06-03 00:00:00
abstract::Interleukin-2 and its receptors are present in hippocampal structures, particularly the pyramidal cell layer. In the present study, we examined the interaction between recombinant human interleukin-2 (rhIL-2) and the voltage-dependent calcium (Ca2+) current using the whole-cell patch-clamp technique. RhIL-2 depressed ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199305000-00030
更新日期:1993-05-01 00:00:00
abstract::The transmissible spongiform encephalopathies (TSEs) invariably result in fatal neurodegeneration and accumulation of PrP, an abnormal form of the host prion protein PrP, encoded by the PRNP gene. A naturally occurring polymorphism (methionine/valine) at PRNP codon 129 is associated with variation in relative disease ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3282f1ca2f
更新日期:2007-12-03 00:00:00
abstract::Previous studies suggest that there is a dopamine lowering process during major depressive episodes (MDE). To investigate this, we measured the dopamine transporter binding potential (DAT BP) in the striatum of depressed and healthy subjects using [(11)C]RTI-32 PET. The DAT, a predominantly presynaptic receptor, decre...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200112210-00052
更新日期:2001-12-21 00:00:00
abstract::One approach to understanding the function of presenilin 1 (PS1), is to discover those proteins with which it interacts. Evidence for a function in developmental patterning came from C. elegans, in which a PS homologue was identified by screening for suppressors of a mutation in Notch/lin-12, a gene which specifies ce...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199704140-00033
更新日期:1997-04-14 00:00:00
abstract::Group III metabotropic glutamate receptors (mGluR4, 6, 7, 8) are negatively coupled to adenylate cyclase and, when activated presynaptically, decrease the release of glutamate and GABA. We have used intracerebroventricular injections of agonists and antagonists believed to act selectively on these receptors to study t...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199606170-00005
更新日期:1996-06-17 00:00:00
abstract::Slices of rat cingulate cortex, when incubated in magnesium-free medium, produce spontaneous epileptiform spikes. Here it is demonstrated that the metabotropic glutamate receptor (mGluR) agonists +/- trans-1-amino-cyclopentane-1,3-dicarboxylic acid (+/- Trans-ACPD), IS3R-ACPD and quisqualic acid (quis) can reduce the ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199210000-00024
更新日期:1992-10-01 00:00:00
abstract::This study aimed to explore the temporal dynamics of the consistency effect in reading Chinese phonograms. High-consistency and low-consistency characters were used in the homophone judgment task, and the event-related potentials were recorded. The data showed that low-consistency characters elicited greater N170 ampl...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e328010d4e4
更新日期:2007-01-22 00:00:00
abstract::Increasing evidence suggests that dynein has an important role in the clearance of misfolded proteins by autophagy. Here we show that treatment of cells with 1-methyl-4-phenylpyridinium (MPP) cause alpha-synuclein overexpression and aggregation, leading to the accumulation of autophagic vacuoles and the recruitment of...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32832986c4
更新日期:2009-04-22 00:00:00
abstract::When we look at our spatial environment we have the feeling that the whole visual field is coloured, yet the density of cone photoreceptors decreases considerably as eccentricity increases. We investigated colour perception (coloured/noncoloured), colour naming and whether colour helps object recognition at eccentrici...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000236864.54575.98
更新日期:2006-10-23 00:00:00
abstract::In neonatal retinal explants cultured long-term green cones are missing. Recently it was reported that thyroid hormone beta2 receptors (TR-beta2) are essential for these green cones to differentiate. Therefore transcript level of these receptors was investigated in our mouse retinal explants. However, thyroid receptor...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200205070-00003
更新日期:2002-05-07 00:00:00
abstract::The study aimed to investigate the time-course of electromagnetic field (EMF)-induced effects on human cognitive and behavioral performance and on tympanic temperature. Subjects were randomly assigned to two groups, exposed to a 902.40 MHz EMF before the testing session, or to the same signal during the data collectin...
journal_title:Neuroreport
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00001756-200401190-00031
更新日期:2004-01-19 00:00:00
abstract::Hydrogen peroxide (H₂O₂) is a ubiquitous reactive oxygen species that can induce several inner ear disorders. In this study, we recorded the potassium (K) currents in acutely isolated inner hair cells of guinea pig cochlea, and investigated the effects of H₂O₂. We also observed the morphological changes in inner hair ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32833fcb56
更新日期:2010-11-17 00:00:00
abstract::Neurons respond to extracellular stimulation by modulating the expression of certain immediate-early genes. Inducible transcription factors (ITFs), such as c-Fos and Zif268, are coded by this class of gene and are among the first proteins to appear. The rapid accumulation of these products combined with histological m...
journal_title:Neuroreport
pub_type: 杂志文章,评审
doi:
更新日期:1997-09-08 00:00:00
abstract::The role of dopaminergic pathways in the retina in controlling the functional state of the pineal was investigated. Dopaminergic agents were injected into the eyes of dark-adapted chickens which were maintained in the dark. Changes in the activity of N-acetyltransferase (NAT) in the retina and pineal were then monitor...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199502000-00010
更新日期:1995-02-15 00:00:00
abstract::The functional integrity of the 'on' and 'off' neurovisual pathways has been examined in the central visual fields of normal (n = 13), glaucomatous (n = 21) and ocular hypertensive (n = 21) individuals. The detection thresholds to light increments (onsets = bright spots) and light decrements (offsets = dark spots) on ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:
更新日期:1993-09-03 00:00:00
abstract::Male Bengalese finches sing complex song sequences during courtship. To examine the female perception of sequence complexity, we tested female auditory processing with respect to sequential differences in the caudomedial nidopallium and caudomedial mesopallium. Repeated song presentations caused lower expression of th...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32833730b7
更新日期:2010-04-21 00:00:00
abstract::This study investigated whether neural mechanisms of self-face recognition are modulated by attention by recording event-related brain potentials associated with self-face recognition. Participants identified head orientations of self-faces and familiar or unfamiliar other faces presented briefly at the center of the ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000203357.65190.61
更新日期:2006-03-20 00:00:00
abstract::We investigated some in vitro pharmacological properties of a novel human dopamine D2-like receptor antagonist, YM-50001 [(R)-5-chloro-4-cyclopropylacarbonylamino-2-methoxy-N-[1-(3-methox ybenzyl)- 3-pyrrolidinyl]benzamide monooxalate]. Receptor binding studies revealed that YM-50001 had a potent affinity for human D4...
journal_title:Neuroreport
pub_type: 杂志文章
doi:
更新日期:1996-11-04 00:00:00
abstract::Basic FGF mRNA induction by bFGF was investigated in cell cultures from rat brain, i.e. postnatal day 2 cortex and embryonic day 18 hippocampus. In situ hybridization shows that after bFGF treatment (10(-10) M) for 14 h neurones and glial cells show a remarkable increase in bFGF mRNA production. Incubation of astrocyt...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199212000-00011
更新日期:1992-12-01 00:00:00
abstract::Deficits of working memory (WM) are recognized as an important pathological feature in schizophrenia. Since the P600 component of event related potentials has been hypothesized that represents aspects of second-pass parsing processes of information processing, and is related to WM, the present study focuses on P600 el...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200109170-00010
更新日期:2001-09-17 00:00:00
abstract::We evaluated the incentive motivational properties of MK-801 by determining its priming effect on drug-seeking behaviour following extinction of cocaine self-administration, an animal model for drug craving. Rats were allowed to self-administrate cocaine (0.5 mg/kg) or saline during 10 daily sessions. MK-801 (0.1-0.25...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199803090-00014
更新日期:1998-03-09 00:00:00
abstract::We earlier showed that leucine-rich glioma inactivated 3 (LGI3) colocalizes with amyloid beta peptide (Abeta) taken up by astrocytes both in vitro and in vivo, and that LGI3 accumulated with endocytosis-associated proteins in aged monkey brains. In this study, we confirmed that LGI3 localizes to the endocytic pathway ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32830a4cc4
更新日期:2008-08-06 00:00:00
abstract::The discovery of mis-sense mutations linking the presenilin-1 (PS-1) gene on chromosome 14 to Alzheimer's disease (AD) has lead to a thorough investigation of this locus. The PS-1 gene contains a polymorphism creating two alleles. The most common allele, allele 1, has been linked with late-onset AD. Given the clinical...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199711100-00042
更新日期:1997-11-10 00:00:00
abstract::The aim of the study was to investigate differences in the distribution of intranasal trigeminal receptors in humans using an electrophysiological measure of trigeminally induced activation, the negative mucosa potential. A total of 29 young, healthy volunteers participated, results were on the basis of data from 18 p...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000224764.61959.e8
更新日期:2006-09-18 00:00:00
abstract::Network tools have been extensively applied to study the properties of brain functional and anatomical networks. In this paper, resiliency of Caenorhabditis elegans cortical networks against cascaded failures is studied. To this end, directed network formed by chemical connections and undirected network formed by elec...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000421
更新日期:2015-08-19 00:00:00
abstract::A two-electrode voltage clamp was used to examine the effects of the local anaesthetics (LAs) lidocaine, tetracaine and bupivacaine, and the meta-isomer of lidocaine (LL33), on the gamma-aminobutyric acid (GABA)-gated Cl- channel in the crayfish stretch receptor neurone. The voltage-induced current changes were record...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199701200-00018
更新日期:1997-01-20 00:00:00
abstract::Both acute and chronic exercise is consistently associated with a number of benefits to physical and mental health, including cardiovascular function, body weight, mood, and cognition. Near-infrared spectroscopy is an ideal method to measure changes in oxygenated and deoxygenated hemoglobin (O2Hb and dHb) levels in th...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000266
更新日期:2014-11-12 00:00:00
abstract::Densities of serotonin transporters (5-HTT) in the postmortem neocortex of behaviorally assessed Alzheimer's disease (AD) patients and aged controls were measured by radioligand binding with [3H]citalopram. It was found that 5-HTT sites in the temporal cortex of AD patients with prominent antemortem anxiety were unalt...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000077546.91466.a8
更新日期:2003-07-18 00:00:00
abstract::Ciliary neurotrophic factor (CNTF) attracts considerable attention because it supports survival and differentiation of various types of neurons and glial cells in vitro. Although CNTF functions as a moderate neurotrophic factor in mature motor neurons, its role in embryonic development remains unknown. Here, we found ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200204160-00039
更新日期:2002-04-16 00:00:00