Abstract:
:Interleukin-2 and its receptors are present in hippocampal structures, particularly the pyramidal cell layer. In the present study, we examined the interaction between recombinant human interleukin-2 (rhIL-2) and the voltage-dependent calcium (Ca2+) current using the whole-cell patch-clamp technique. RhIL-2 depressed a fraction of the inward Ca2+ current in acutely dissociated guinea-pig hippocampal CA1 neurons. This depression is rapid, dose-dependent with 0.001-1.0 ng rhIL-2/10 microliters (6.8 x 10(-12) to 6.8 x 10(-9) M) and reversible in > 80% of the neurons. Heat-inactivated rhIL-2 had no effect. The application of anti-rhIL-2 monoclonal antibody inhibited the rhIL-2-induced depression of the Ca2+ current. The depression of the Ca2+ current by IL-2 may play a role in the induction and/or progression of neuropathological processes of immunological origin, and in the induction of neurological manifestations during IL-2 immunotherapy.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Plata-Salamán CR,ffrench-Mullen JMdoi
10.1097/00001756-199305000-00030subject
Has Abstractpub_date
1993-05-01 00:00:00pages
579-81issue
5eissn
0959-4965issn
1473-558Xjournal_volume
4pub_type
杂志文章相关文献
NEUROREPORT文献大全abstract::The 6-hydroxydopamine rat model of Parkinson's disease was combined with intracerebral drug infusions to examine the influence of glutamate receptors on striatal output activity. When infused into the dopamine-denervated striatum, the AMPA-kainate receptor antagonist DNQX dose-dependently elicited contralateral rotati...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199512150-00034
更新日期:1995-12-15 00:00:00
abstract::Sleep disorders increase with ageing. The serotonergic system has been linked with sleep regulation. In fatal familial insomnia, a prion disease with insomnia as one major clinical feature, we recently observed a disturbance in the serotonergic system as likely substrate of typical symptoms. Using immunohistochemistry...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200103260-00010
更新日期:2001-03-26 00:00:00
abstract::We recently reported behavioral improvements following intrastriatal transplantation of cryopreserved cultured human neuroteratocarcinoma-derived cells (hNT neurons) in rats with cerebral ischemia induced by occlusion of the middle cerebral artery. In the present study, the viability and survival of hNT neurons were e...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199808240-00028
更新日期:1998-08-24 00:00:00
abstract::The distribution of the enzyme NADPH diaphorase in the region of the periaqueductal gray (PAG) was studied in the rat, rabbit, cat, monkey and human. In each species, the enzyme labelled a small band of neurones located below the level of the aqueduct and directly above the supraoculomotor gray in the middle of the an...
journal_title:Neuroreport
pub_type: 杂志文章
doi:
更新日期:1994-11-21 00:00:00
abstract::When a food is eaten to satiety, its reward value decreases. This decrease is usually greater for the food eaten to satiety than for other foods, an effect termed sensory-specific satiety. In an fMRI investigation it was shown that for a region of the orbitofrontal cortex the activation produced by the odour of the fo...
journal_title:Neuroreport
pub_type: 更正并重新发布的文章,杂志文章
doi:10.1097/00001756-200003200-00046
更新日期:2000-03-20 00:00:00
abstract::Homotopic and isochronic transplantation of the alar plate of the rhombomeres 7 and 8 was performed between chick and quail embryos at the stage of 10-14 somites. Analysis of the graft derivatives in 12-day-old chimeric embryos by means of the quail nucleolar marker showed that the ipsilateral inferior olive is formed...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199605170-00013
更新日期:1996-05-17 00:00:00
abstract::Recent studies have shown the nutrient-sensing systems transmitting nutritive information from the gut to the brain. However neural activity evoked by ingested dietary nutrients has not been investigated adequately. Using functional magnetic resonance imaging, we demonstrated that rat forebrain responded to intragastr...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e328307c414
更新日期:2008-07-16 00:00:00
abstract::The trembler mouse suffers from a dominantly inherited mutation of the peripheral myelin protein 22 (PMP-22) gene which results in abnormal myelination of the peripheral nervous system. However, the clinical symptoms observed in the mutant suggest abnormalities in the central nervous system. Using the Northern blot te...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199406020-00015
更新日期:1994-06-02 00:00:00
abstract::Groups of 20 C57BL/6J mice (10 males and 10 females) were given BSE strain 301C i.p. and subsequently given 2 microg recombinant human TGFbeta1 s.c. at single or multiple times. There was a significant positive correlation between the day of TGFbeta1 administration and incubation time; the later TGFbeta1 was administe...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200410050-00018
更新日期:2004-10-05 00:00:00
abstract::Experience affects how brains respond to sound. Here, we examined how the sensitivity and selectivity of auditory cortical neuronal responses were affected in adult rats by the repeated presentation of a complex sound that was paired with basal forebrain stimulation. The auditory cortical region that was responsive to...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200107200-00047
更新日期:2001-07-20 00:00:00
abstract::The function of the lateral part of the human cerebellum was investigated through cerebro-cerebellar functional connectivity. We propose a laterality index method to reveal a functional and possibly anatomical pathway between the cerebral cortex and the cerebellum. The brain activity involved in learning a visually-gu...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199902050-00022
更新日期:1999-02-05 00:00:00
abstract::Light physiologically regulates the levels of c-Fos in the suprachiasmatic nucleus (SCN), but the identity of most of the cells that express this DNA-binding protein is unknown. To determine whether SCN c-Fos expression is restricted to neurons, we performed light microscopic double-label immunohistochemistry on secti...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199409080-00012
更新日期:1994-09-08 00:00:00
abstract::Autophagy and neurogenesis play a pivotal role in maintaining cellular homeostasis of neurons in the brain. Endurance exercise (EXE) serves as a potent regulator of both autophagy and neurogenesis in the hippocampus of the brain; however, the underlying molecular mechanisms of the dual expression remains unclear. Thus...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001431
更新日期:2020-04-08 00:00:00
abstract::N-methyl-D-aspartate (NMDA) receptors are hetero-oligomeric receptor-channel complexes composed of NR1 and NR2 subunits. Subunit composition determines the properties of NMDA receptor subtypes. However, the molecular mechanisms regulating their subunit composition are unknown. Using reverse transcription (RT)-competit...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199712010-00015
更新日期:1997-12-01 00:00:00
abstract::Evoked magnetic fields over the entire head were measured during a semantic judgment task, in which conditions of the pre-test learning session were manipulated. Subjects learnt related and unrelated category-noun pairs, and were then asked to judge the relationship between category and noun. Unrelated pairs evoked ac...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200102120-00005
更新日期:2001-02-12 00:00:00
abstract::Reading is a learned skill that is likely influenced by both brain maturation and experience. Functional imaging studies have identified brain regions important for skilled reading, but the structural brain changes that co-occur with reading acquisition remain largely unknown. We investigated maturational volume chang...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000121
更新日期:2014-03-26 00:00:00
abstract::Experiments using chimeric stimuli have shown that the right hemisphere is more influential in processing facial information. Here, again, we found clear evidence that study participants used the information from the left side of the face to inform their gender decisions when chimeric male/female, female/male stimuli ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200512190-00004
更新日期:2005-12-19 00:00:00
abstract::Recent reports have suggested the existence of a causal relationship between impaired regression of multiple climbing fibre innervation and impaired motor coordination in protein kinase C gamma subunit (PKC gamma) mutant mice. In the present patch-clamp study, performed in thin cerebellar slices prepared from adult mu...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199701200-00038
更新日期:1997-01-20 00:00:00
abstract::Adrenomedullin (ADM) is a 52 amino acid peptide with multiple physiological functions and wide tissue distributions including brain. Recently, elevated plasma levels of ADM were found in patients with schizophrenia, bipolar affective disorder and autism, suggesting the involvement of ADM in the pathophysiology of ment...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000132202.69212.79
更新日期:2004-06-28 00:00:00
abstract::In several central nervous system neuronal populations, axotomy triggers the upregulation of regeneration-associated genes such as c-Jun, which determines neurons ability to regenerate axon in a growth-permissive environment. We analyzed the expression of c-Jun in rat ventral medullary neurons after cervical hemisecti...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000179075.32035.0f
更新日期:2005-09-28 00:00:00
abstract::In order to ascertain whether disturbances of neurogenesis occur in chronic neurodegenerative disorders, we assessed hippocampal cell proliferation in the R6/1 transgenic mouse model of Huntington's disease (HD). Using BrdU labelling for dividing cells at two different time points (5 and 20 weeks) in transgenic and wi...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200404090-00014
更新日期:2004-04-09 00:00:00
abstract::In the adult rat hippocampal formation, neurogenesis occurs in the dentate gyrus subgranular zone (SGZ). We used laser capture microdissection and an antidepressant-related genes microarray to analyze gene expression profiles of cells from the SGZ and from the outermost granule cell layer. Of the differentially expres...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3283350b24
更新日期:2010-01-27 00:00:00
abstract::Absence seizures are known to originate from disruptions within the corticothalamocortical network; however, the precise underlying cellular and molecular mechanisms that induce hypersynchronicity and hyperexcitability are debated and likely to be complex and multifactorial. Recent studies implicate impaired thalamic ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000909
更新日期:2017-12-13 00:00:00
abstract::To test the hypothesis that the pedunclopontine tegmental nucleus (PPTg) plays a role in anxiety, rats with electrolytic lesions of the PPTg were tested in two animal models of anxiety, the elevated plus maze and the social interaction tests. Histological analysis showed that lesions were concentrated on the caudal ha...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199806010-00020
更新日期:1998-06-01 00:00:00
abstract::A bilateral spino-bulbo-spinal circuit conveys information from/to the male urogenital tract and perineal muscles. This is the first electrophysiological report of another descending pathway, one which conveys output from the medullary reticular formation (MRF) to activate postganglionic sympathetic fibers contained w...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200002070-00031
更新日期:2000-02-07 00:00:00
abstract::The environment in which cocaine is experienced becomes associated with the effects of the drug and can then elicit cocaine craving. This study examined whether the hippocampus is involved in such associations using the conditioned place preference model. Rats received bilateral lesions of the dorsal or ventral hippoc...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200311140-00023
更新日期:2003-11-14 00:00:00
abstract::Over 30% of normal elderly people have cerebral amyloid angiopathy (CAA). Possession of APOE epsilon4 is associated with increased prevalence and severity of CAA in Alzheimer's disease (AD) and in cerebral haemorrhage. We examined CAA in relation to APOE genotype in brains from 152 people aged 60-102 years, without AD...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200308060-00027
更新日期:2003-08-06 00:00:00
abstract::Cultured cerebellar granule neurons were used to examine the hypothesis that NMDA or KCl-dependent Ca2+ influx activates a signaling cascade mediating transcription, translation and assembly of neurofilaments. The data indicate that 25 mM KCl and 140 microM NMDA induce neurofilament protein, mRNA, and assembly in neur...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200311140-00013
更新日期:2003-11-14 00:00:00
abstract::Autism is a neurodevelopmental disorder characterized by preserved visual abilities as well as a special profile for visual cognition. We examined the visual cortex of high-ability individuals with autism in order to assess whether the presence of abnormalities at the primary sensory level in autism could be the basis...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200402090-00011
更新日期:2004-02-09 00:00:00
abstract::Frontolimbic structures involved in fear conditioning have also been associated with hypothalamic-pituitary-adrenal (HPA)-axis modulation, including amygdaloid, hippocampal, and ventromedial prefrontal cortex regions. Although HPA-axis function and endocrine changes have been investigated in the context of stress prov...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e328326a031
更新日期:2009-03-04 00:00:00