Abstract:
:Over 30% of normal elderly people have cerebral amyloid angiopathy (CAA). Possession of APOE epsilon4 is associated with increased prevalence and severity of CAA in Alzheimer's disease (AD) and in cerebral haemorrhage. We examined CAA in relation to APOE genotype in brains from 152 people aged 60-102 years, without AD or cerebral haemorrhage. Prevalence of CAA increased with age (p = 0.003). CAA was not associated with APOE genotype. The frequency of epsilon4 showed a significant negative association with age (p = 0.016). Age at death was significantly lower in those with than without epsilon4 (p = 0.028). Possession of epsilon4 does not by itself confer an increased risk of CAA but may be associated with reduced longevity even in the absence of AD or cerebral haemorrhage.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Love S,Nicoll JA,Hughes A,Wilcock GKdoi
10.1097/00001756-200308060-00027subject
Has Abstractpub_date
2003-08-06 00:00:00pages
1535-6issue
11eissn
0959-4965issn
1473-558Xjournal_volume
14pub_type
杂志文章相关文献
NEUROREPORT文献大全abstract::This study used functional magnetic resonance imaging to characterize hemodynamic activation patterns recruited when the participants viewed mixed social communicative messages during a common interpersonal exchange. Mixed messages were defined as conflicting sequences of biological motion and facial affect signals th...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3283455c23
更新日期:2011-06-22 00:00:00
abstract::To assess the effect of endothelial progenitor cells on the axon growth of cortex neurons, we transplanted CD133 cells derived from human peripheral blood to an organotypic coculture system consisting of spinal cord and cortex from neonatal rats. The axon growth from cortex to spinal cord was significantly promoted in...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3282ff6396
更新日期:2008-05-28 00:00:00
abstract::The neurotrophin-inducible gene VGF plays an important role in the maintenance of organismal energy balance and in the mediation of hippocampal synaptic activity. The regulatory mechanism of VGF transcription is not fully understood. The neuron-restrictive silencer factor (NRSF) binds with the neuron-restrictive silen...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000316
更新日期:2015-02-11 00:00:00
abstract::Metabotropic glutamate receptor mGluR1a was expressed in human embryonic kidney 293 cells. 1S,3R-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD) stimulated dose-dependently, phosphoinositide (PI) hydrolysis in transfected, but not in non-transfected cells. The polyamine spermine did not affect PI hydrolysis in th...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199306000-00059
更新日期:1993-06-01 00:00:00
abstract::In this experiment, event-related potentials were used to examine whether the neural correlates of encoding processes predicting subsequent successful recall differed from those predicting successful source memory retrieval. During encoding, participants studied lists of words and were instructed to memorize each word...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32835d8452
更新日期:2013-03-06 00:00:00
abstract::In acute experiments, the effects of i.p. 17beta-estradiol on the activity of arcuate neurons were studied in ovariectomized rats. 17Beta-estradiol (100 microg/100g, i.p.) increased the spontaneous activity of the observed arcuate neurons with a latency of 20-25 min. In some neurons spontaneous activity could be influ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199911260-00034
更新日期:1999-11-26 00:00:00
abstract::The aim of the present study was to determine if both inactivating and non-inactivating potassium currents occur in skeletal muscle cells at early times in culture. Whole cell current was recorded from embryonic muscle cells within 4-10 h of plating. We found that in the cells which had an outward current, half had a ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199204000-00007
更新日期:1992-04-01 00:00:00
abstract::Protease-activated receptor-2 (PAR-2), a member of the G protein-coupled, seven trans-membrane domain receptor family, is activated by trypsin/tryptase and present in various tissues including the primary sensory neurons, playing a role in development of neurogenic inflammation. The present study examined if activatio...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200103260-00020
更新日期:2001-03-26 00:00:00
abstract::The tetrodotoxin-resistant voltage-gated sodium channel Nav 1.8 is expressed only in nociceptive sensory neurons. This channel has been proposed to contribute significantly to the sensitization of primary sensory neurons after injury. We have studied the nociceptive behaviours of mice carrying a null mutation in the N...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200110080-00019
更新日期:2001-10-08 00:00:00
abstract::Interleukin-6 (IL-6) is a neurotrophic cytokine, however, its direct effect on nerve regeneration has not been well characterized. We therefore examined the effect of IL-6 on neurite regeneration using the rat dorsal root ganglion. IL-6 significantly enhanced neurite regeneration from transected nerve terminals. We al...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200104170-00043
更新日期:2001-04-17 00:00:00
abstract::Using immunohistochemistry, we investigated in the cat the effects of MPTP, a Parkinsonian syndrome-inducing substance, on brain type B monoamine oxidase (MAO-B) which is responsible for the conversion of MPTP to its neurotoxic product (MPP+). Intraperitoneal administration of MPTP (5 mg kg-1 daily for 5 days) caused ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199501000-00024
更新日期:1995-01-26 00:00:00
abstract::Oleic acid, a cis-unsaturated free fatty acid, is proposed to be involved in the protein kinase C (PKC) activation pathway. Its biological actions, however, have not been well-characterized. We examined the effects of oleic acid on acetylcholine (ACh)-gated channel currents using Torpedo nicotinic ACh receptors expres...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199702100-00004
更新日期:1997-02-10 00:00:00
abstract::Acute injury to central nervous system (CNS) triggers neurodegenerative processes that can result in serious damage or complete loss of function. After injury, production of transforming growth factor β1 (TGFβ1) increases and initiates creation of a fibrotic scar that prevents normal growth, plasticity, and recovery o...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000106
更新日期:2014-03-26 00:00:00
abstract::Demyelinated CNS axons can be remyelinated by Schwann cells. A recent study concluded that with time Schwann cell remyelination is replaced by oligodendrocyte remyelination [9]. To examine this, the extent of Schwann cell and oligodendrocyte remyelination at 4, 6.5 and 24 weeks was determined for ethidium bromide lesi...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200207020-00027
更新日期:2002-07-02 00:00:00
abstract::Menthol is known as an agonist for cold-sensitive transient receptor potential channels (TRPM8) and also as a direct modulator of GABA channels. We examined the effects of menthol on respiratory rhythm generation in the brainstem-spinal cord preparations isolated from newborn rats. Menthol decreased respiratory rhythm...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3283405bad
更新日期:2010-12-08 00:00:00
abstract::Eleven early-onset dementia families, all with affected individuals who have either presented clinical symptoms of early onset familial Alzheimer's disease (EOFAD) or have been confirmed to have EOFAD by autopsy, and two early onset cases with biopsy-confirmed AD pathology, were screened for missense mutations in the ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199704140-00043
更新日期:1997-04-14 00:00:00
abstract::Intraplantar carrageenan induced a peripheral oedema and c-Fos like immunoreactivity (Fos-LI) in L4-L5 segments in the dorsal horn (DH) of the rat spinal cord. The total number of carrageenan evoked Fos-LI neurones was 153 +/- 10 per section, with a predominant localization in the superficial and deep laminae of the D...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199507100-00006
更新日期:1995-07-10 00:00:00
abstract::NONINVASIVE photolytic injury to targeted neuronal subpopulations in vivo causes unique, slowly progressive neuronal degeneration. To examine the mechanisms of degeneration toward development and transplantation studies, cytosolic calcium levels were measured in vitro from neocortical neurons after incorporation of ph...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199208000-00014
更新日期:1992-08-01 00:00:00
abstract::Hypoxia-inducible factor-1 (HIF-1) regulates the expression of neuroprotective genes such as erythropoietin (EPO). We investigated the mechanism by which zinc, an excitotoxin-like metal, regulates HIF-1 under hypoxic conditions in astrocytes. In hypoxic LN215 cells, HIF-1alpha stabilized and accumulated in the nucleus...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e328304d9ac
更新日期:2008-07-02 00:00:00
abstract::We recently reported behavioral improvements following intrastriatal transplantation of cryopreserved cultured human neuroteratocarcinoma-derived cells (hNT neurons) in rats with cerebral ischemia induced by occlusion of the middle cerebral artery. In the present study, the viability and survival of hNT neurons were e...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199808240-00028
更新日期:1998-08-24 00:00:00
abstract::The time course of responses to repeated presentations of affective stimuli is well characterized in healthy individuals but remains to be characterized in patients with bipolar disorder. Using functional magnetic resonance imaging, we compared early-stage and late-stage brain activation during a two-block fearful fac...
journal_title:Neuroreport
pub_type: 临床试验,杂志文章
doi:10.1097/WNR.0b013e328310af58
更新日期:2008-10-08 00:00:00
abstract::Texas Red-labelled dextran with a mol. wt of 3000 g mol-1, a marker for the extracellular space, was injected unilaterally into the neostriatum of adult rats (0.3-30 micrograms microliter-1) and its distribution evaluated 1 min to 5 h later. Diffusion in the neuropil was observed with clearance starting after 30 min. ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199505090-00014
更新日期:1995-05-09 00:00:00
abstract::This study aimed to evaluate the potential of bone marrow stromal cells for treatment of inner ear diseases. Autologous marrow cells labeled with Dil were implanted into the inner ear of five gentamicin-treated chinchillas. Histological analysis 3 weeks later revealed robust survival of grafted marrow cells in multipl...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200401190-00001
更新日期:2004-01-19 00:00:00
abstract::Previous event-related potential studies in Indo-European languages reported a surprising finding that failed syntactic category processing appears to block lexical-semantic integration, suggesting a functional primacy of syntax over semantics. An event-related potential experiment was conducted to test whether there ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3282fda21d
更新日期:2008-05-07 00:00:00
abstract::Papaverine is a non-specific vasodilatory drug, which was found to unexpectedly cause opening of the blood-brain barrier (BBB). We studied the expression of two endothelial cell related markers, endothelial barrier antigen (EBA) as a marker of BBB intactness, and matrix metalloproteinase-9 (MMP-9), an extracellular ma...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200212030-00011
更新日期:2002-12-03 00:00:00
abstract::We investigated the mode of action of argiotoxin636 on isolated N-methyl-D-aspartate (NMDA) receptor channels in cultured cerebellar granule cells. We found that the toxin blocks NMDA channels by decreasing their opening probability and by inducing a flickering activity, in a voltage-dependent manner. Our results indi...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199505090-00022
更新日期:1995-05-09 00:00:00
abstract::We studied whether pro-survival Akt was activated after transient focal cerebral ischemia and whether it inhibited pro-apoptotic Bad. Phosphorylation of Akt (serine-473) was enhanced in cortex after 1-hour ischemia, and also after 1h and 6 h of reperfusion, but it returned back to that in controls by 24 h. After this ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200110290-00046
更新日期:2001-10-29 00:00:00
abstract::Microglia are the only immunocompetent cells resident in the central nervous system which are capable of protecting the brain from infection and tumors. These resident macrophages possess a vast array of mechanisms for the destruction of bacteria and tumor cells. One of these mechanisms involves the generation of nitr...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199404000-00031
更新日期:1994-04-14 00:00:00
abstract::Nerve damage often leads to nervous system dysfunction and neuropathic pain. The serine-threonine kinases receptor-interacting protein 1 (RIP1) and 3 (RIP3) are associated with inflammation and cell necrosis. This study aimed to explore the role of RIP1 and RIP3 in sciatic nerve chronic constriction injury (CCI) in mi...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001120
更新日期:2018-11-07 00:00:00
abstract::In the present study, the activity changes of chicken retinal ganglion cells in response to light stimuli with defined contrast were investigated, in the presence of various levels of sustained background illumination. Following a step increase of light illumination, the firing rate of most retinal ganglion cells incr...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200503150-00013
更新日期:2005-03-15 00:00:00