Abstract:
:To assess the effect of endothelial progenitor cells on the axon growth of cortex neurons, we transplanted CD133 cells derived from human peripheral blood to an organotypic coculture system consisting of spinal cord and cortex from neonatal rats. The axon growth from cortex to spinal cord was significantly promoted in cultures after CD133 cells transplantation compared with that of the control cultures. In addition, real-time reverse transcription-PCR showed a significant upregulation of vascular endothelial growth factor mRNA in the spinal cord of the cultures containing CD133 cells. In contrast, the transplanted cells did not differentiate into endothelial cells. These data suggest that CD133 cells may promote axonal regeneration by upregulating vascular endothelial growth factor mRNA in spinal cord tissues.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Yamamoto R,Ishikawa M,Tanaka N,Kamei N,Nakanishi K,Sasaki H,Nakamae T,Mochizuki Y,Asahara T,Ochi Mdoi
10.1097/WNR.0b013e3282ff6396subject
Has Abstractpub_date
2008-05-28 00:00:00pages
799-803issue
8eissn
0959-4965issn
1473-558Xpii
00001756-200805280-00002journal_volume
19pub_type
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