Abstract:
:In the water-maze test, the linoleic acid derivative, 8-[2-(2-pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid (DCP-LA) (1 mg/kg, intraperitoneally), significantly shortened the prolonged latency for accelerated-senescence-prone mice 8 (SAMP8), reaching a level similar to the latency for accelerated-senescence-resistant mice 1 (SAMR1) as control. In the open-field test to assess motor activity, it was confirmed that the DCP-LA effect is not due to increased motor activity. In the passive avoidance test to assess fear memory, DCP-LA had no effect on the latency of acquisition and retention for SAMP8. The results of the present study, thus, suggest that DCP-LA could improve age-related learning impairment by enhancing cognitive functions.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Yaguchi T,Nagata T,Mukasa T,Fujikawa H,Yamamoto H,Yamamoto S,Iso H,Tanaka A,Nishizaki Tdoi
10.1097/01.wnr.0000194388.12408.0asubject
Has Abstractpub_date
2006-01-23 00:00:00pages
105-8issue
1eissn
0959-4965issn
1473-558Xpii
00001756-200601230-00022journal_volume
17pub_type
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