Benzodiazepines modulate calcium spikes in young and adult hippocampal cells.

Abstract:

:GABAA receptor-independent effects of benzodiazepine receptor (BZ-R) agonists on calcium and barium spikes were recorded intracellularly in the presence of bicuculline from CA3 hippocampal cells of young and adult rats. Zolpidem (omega 1 BZ-R agonist), had no effects in young animals but decreased calcium and barium spikes and barium currents in adults. Midazolam (omega 1 and omega 2 BZ-R agonist) increased barium spikes in both young and adult animals. The effects on calcium spikes were more complex since a decrease was sometimes preceded by an increase. Thus, in adults zolpidem acting on omega 1 BZ-R reduced calcium influx while in young rats midazolam acting on omega 2 BZ-R increased barium influx. This modulation of calcium spikes by benzodiazepines could be relevant of calcium spikes by benzodiazepines could be relevant because of the developmental role played by calcium dependent processes.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Rovira C,Ben-Ari Y

doi

10.1097/00001756-199410270-00034

subject

Has Abstract

pub_date

1994-10-27 00:00:00

pages

2125-9

issue

16

eissn

0959-4965

issn

1473-558X

journal_volume

5

pub_type

杂志文章
  • Neural mechanisms of the octave illusion: electrophysiological evidence for central origin.

    abstract::The octave illusion is experienced when two simultaneous tones, separated by one octave and presented to the opposite ears, are continuously reversed between the two ears. Subjects consistently report a sequence of alternating single tones: the high tone in the right ear and the low in the left. We wished to determine...

    journal_title:Neuroreport

    pub_type: 临床试验,杂志文章

    doi:10.1097/00001756-199612200-00060

    authors: Ross J,Tervaniemi M,Näätänen R

    更新日期:1996-12-20 00:00:00

  • Postural effects of motion vision in young autistic children.

    abstract::We present the first assessment of motion vision in childhood autism. Postural reactivity to visually perceived motion was measured in five autistic children and 12 normal controls of the same chronological age. Anteroposterior as well as total body sway occurring on a force platform in response to movements in the vi...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199505300-00034

    authors: Gepner B,Mestre D,Masson G,de Schonen S

    更新日期:1995-05-30 00:00:00

  • MRI of subacute hemorrhagic transformation in the rat suture occlusion model.

    abstract::In this study we investigated the utility of different MRI techniques for the detection and predictability of hemorrhagic transformation (HT) in a rat model of transient focal cerebral ischemia. Hemorrhagic infarction was reliably identified with gradient-echo sequences and developed between 2 and 7 days following the...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200102120-00025

    authors: Neumann-Haefelin T,Kastrup A,de Crespigny A,Ringer TM,Sun GH,Yenari MA,Moseley ME

    更新日期:2001-02-12 00:00:00

  • An event-related potential investigation of spatial attention orientation in children trained with mental abacus calculation.

    abstract::The objective of this study was to investigate the effects of long-term mental abacus calculation training (MACT) on children's spatial attention orientation. Fifteen children with intensive MACT (MACT group) and 15 children without MACT (non-MACT group) were selected. The two groups of children were matched in age, s...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000000705

    authors: Liu X,Sun Y

    更新日期:2017-01-01 00:00:00

  • Modification of cytokine secretion following mild emotional stimuli.

    abstract::In the present study, changes in the cytokine system (IL-1 beta, IL-2, IL-3, IL-6 and TNF alpha) were assessed following exposure to mild mood induction (negative and positive) in humans. An increase in secretion of TNF alpha, a decrease in that of IL-2 and of IL-3 with no change in IL-1 beta and in IL-6 secretion lev...

    journal_title:Neuroreport

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00001756-199503270-00021

    authors: Mittwoch-Jaffe T,Shalit F,Srendi B,Yehuda S

    更新日期:1995-03-27 00:00:00

  • Phenylketonuria-related synaptic changes in a BTBR-Pah(enu2) mouse model.

    abstract::Phenylketonuria is the most common, inherited aminoacidopathy associated with brain injury. To date, no study has focused on the neuropathology of the genetic mouse model of phenylketonuria, BTBR-Pah(enu2). We examined dendritic spines and synapses in the CA1 and prefrontal cortex among the wild-type, heterozygous, an...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e3283495acc

    authors: Liang L,Gu X,Lu L,Li D,Zhang X

    更新日期:2011-08-24 00:00:00

  • A novel animal model of acute cochlear mitochondrial dysfunction.

    abstract::Acute mitochondrial dysfunction in the cochlea is likely to result in hearing loss as a consequence of local energy shortage, similar to ischemia- or noise-induced hearing loss. To establish an animal model of acute cochlear mitochondrial dysfunction, we applied a mitochondrial toxin, 3-nitropropionic acid (3-NP) in t...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/01.wnr.0000133226.94662.80

    authors: Hoya N,Okamoto Y,Kamiya K,Fujii M,Matsunaga T

    更新日期:2004-07-19 00:00:00

  • Neural manifestation of cognitive and precognitive mismatch detection in early infancy.

    abstract::We recorded event-related potentials (ERPs) in 2-month-old infants in two different states of alertness: awake and asleep. Syllables varying in vowel duration (long vs short) were presented in an oddball paradigm, known to elicit a mismatch brain response. ERPs of both groups showed a mismatch response reflected in a ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200207190-00006

    authors: Friederici AD,Friedrich M,Weber C

    更新日期:2002-07-19 00:00:00

  • Increased startle responses in mice carrying mutations of glycine receptor subunit genes.

    abstract::An exaggerated startle response caused by mutations of the alpha 1 subunit gene of the inhibitory glycine receptor (GLRA1) is the key symptom of human hyperekplexia or startle disease. The recessive mouse mutant spasmodic (spd) carries a missense mutation in the corresponding murine Glra1 gene which reduces the affini...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199602290-00030

    authors: Koch M,Kling C,Becker CM

    更新日期:1996-02-29 00:00:00

  • Combined blockade of NMDA and non-NMDA receptors produces respiratory arrest in the adult cat.

    abstract::We studied the effects of the non-NMDA antagonist NBQX and of the NMDA antagonist dizocilpine (MK-801), administered separately or together, on the respiratory function of conscious cats. NBQX (20 mg kg-1) did not affect minute ventilation nor the timing of inspiratory and expiratory phases, but the addition of a smal...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199401120-00028

    authors: Foutz AS,Pierrefiche O,Denavit-Saubié M

    更新日期:1994-01-12 00:00:00

  • Semantic sentence processing reflected in the event-related potentials of one- and two-year-old children.

    abstract::The present study used the N400, an electrophysiological correlate of semantic processing, to investigate 19- and 24-month-old children's ability to integrate the meaning of words in a sentential context. Children listened passively to semantically appropriate sentences and to sentences in which the object noun violat...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/01.wnr.0000185013.98821.62

    authors: Friedrich M,Friederici AD

    更新日期:2005-11-07 00:00:00

  • Matrix metalloproteinase-9 is elevated in serum of patients with amyotrophic lateral sclerosis.

    abstract::Matrix metalloproteinase-9 (MMP-9) and its specific inhibitor, tissue inhibitor of matrix metalloproteinase-1 (TIMP-1), were analysed by enzyme-linked immunosorbent assay (ELISA) and by zymography in serum and cerebrospinal fluid (CSF) of patients with amyotrophic lateral sclerosis (ALS). In contrast to patients with ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200011090-00003

    authors: Beuche W,Yushchenko M,Mäder M,Maliszewska M,Felgenhauer K,Weber F

    更新日期:2000-11-09 00:00:00

  • The pattern and distribution of calcitonin gene-related peptide (CGRP) terminals in the rat dorsal following neonatal peripheral inflammation.

    abstract::Neonatal peripheral inflammation has been shown to alter the neural circuitry of the spinal cord in adult rats. However, the temporal and spatial changes in the distribution of primary afferent terminals immediately following a neonatal inflammatory stimulus remains unclear. In the present study we found that intrapla...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200310270-00007

    authors: Ling QD,Chien CC,Wen YR,Fu WM,Sun WZ

    更新日期:2003-10-27 00:00:00

  • Topographical differences in the trigeminal sensitivity of the human nasal mucosa.

    abstract::The aim of the study was to investigate differences in the distribution of intranasal trigeminal receptors in humans using an electrophysiological measure of trigeminally induced activation, the negative mucosa potential. A total of 29 young, healthy volunteers participated, results were on the basis of data from 18 p...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/01.wnr.0000224764.61959.e8

    authors: Scheibe M,Zahnert T,Hummel T

    更新日期:2006-09-18 00:00:00

  • Acute adaptive changes in food intake pattern following olfactory ablation in rats.

    abstract::We determined whether acute compensatory feeding pattern changes after bulbectomy persist on a chronic basis, or whether physiological adaptation occurs to normalize acute changes. Rats were randomized to olfactory bulbectomy or sham operation; all had jugular vein catheterization. Food intake, meal number and size we...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199704140-00023

    authors: Meguid MM,Koseki M,Yang ZJ,Gleason JR,Laviano A

    更新日期:1997-04-14 00:00:00

  • Effects of body weight-supported treadmill training at different speeds on the motor function and depressive behaviors after spinal cord injury in rats.

    abstract::Spinal cord injury (SCI) causes motor dysfunction and depression, which hinders the recovery of motor function. Body weight-supported treadmill training (BWSTT) should be considered an effective method for functional rehabilitation after SCI, as it is an efficacious intervention in healthcare with no side effects. Bec...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000001543

    authors: Liu CH,Zhao BL,Li WT,Zhou XH,Jin Z,An LB

    更新日期:2020-12-16 00:00:00

  • Localization of the somatostatin sst2(a) receptor in human cerebral cortex, hippocampus and cerebellum.

    abstract::The distribution and cellular localization of the somatostatin sst2(a) receptor was investigated in selected human brain areas using an anti-peptide antibody raised against a carboxy-terminal portion of the receptor protein. The sst2(a) receptor was found to be present on neurones and processes in the deep layers of t...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199802160-00027

    authors: Schindler M,Holloway S,Humphrey PP,Waldvogel H,Faull RL,Berger W,Emson PC

    更新日期:1998-02-16 00:00:00

  • LTP of spinal A beta and C-fibre evoked responses after electrical sciatic nerve stimulation.

    abstract::Plasticity in the central nervous system may play an important role in clinical pain. The present study shows that long-term potentiation (LTP) may be induced in single wide dynamic range (WDR) neurons in the dorsal horn after high-frequency stimulation of the sciatic nerve in intact urethane anaesthetized rats. Extra...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199711100-00002

    authors: Svendsen F,Tjølsen A,Hole K

    更新日期:1997-11-10 00:00:00

  • Expression of calsenilin in neurons and astrocytes in the Alzheimer's disease brain.

    abstract::Calsenilin, a multifunctional Ca2+-binding protein, has been identified as an Alzheimer's disease-associated presenilin interactor. Here, we investigated the histochemical localization of calsenilin and its expression levels in the brains of sporadic Alzheimer's disease. Both messenger RNA and protein expression of ca...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200504040-00007

    authors: Jin JK,Choi JK,Wasco W,Buxbaum JD,Kozlowski PB,Carp RI,Kim YS,Choi EK

    更新日期:2005-04-04 00:00:00

  • Intracellular calcium signals in the surround of rat visual cortex lesions.

    abstract::Focal lesions of the visual cortex induce deafferentiation, excitotoxic cell death as well as functional reorganization in the surrounding tissue. The intracellular second messenger calcium is involved in a wide range of cellular responses including excitotoxicity and functional reorganization following cortical injur...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200110080-00009

    authors: Barmashenko G,Eysel UT,Mittmann T

    更新日期:2001-10-08 00:00:00

  • Repetitive transcranial magnetic stimulation over the right dorsolateral prefrontal cortex affects strategic decision-making.

    abstract::Although decision-making is typically seen as a rational process, emotions play a role in tasks that include unfairness. Recently, activation in the right dorsolateral prefrontal cortex during offers experienced as unfair in the Ultimatum Game was suggested to subserve goal maintenance in this task. This is restricted...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/01.wnr.0000183907.08149.14

    authors: van 't Wout M,Kahn RS,Sanfey AG,Aleman A

    更新日期:2005-11-07 00:00:00

  • Context-dependent representation of reinforcement in monkey amygdala.

    abstract::It has been reported that neurons in the amygdala respond to visual cues that predict reward and aversive outcomes. However, it remains unclear whether the representation of reinforcement in the amygdala depends on the relative preference for an outcome compared with another simultaneously available outcome. In this s...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e3283294a2f

    authors: Hirai D,Hosokawa T,Inoue M,Miyachi S,Mikami A

    更新日期:2009-04-22 00:00:00

  • Enhancement of electrically evoked startle-like responses by tetanic stimulation of the superior colliculus.

    abstract::Single-pulse unilateral electrical stimulation of either the amygdala or the inferior colliculus elicited startle-like responses in chloral hydrate anesthetized rats. EMG responses to intracranial stimulation were recorded from the anterior biceps femoris muscles. The EMG responses were generally enhanced following un...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200210070-00015

    authors: Lin C,Wan X,Zhao W,Ma C,Ma C,Gao Y,Zhou Y,Yeomans JS,Li L

    更新日期:2002-10-07 00:00:00

  • BoNT/E prevents seizure-induced activation of caspase 3 in the rat hippocampus.

    abstract::Clinical and experimental studies clearly demonstrate that prolonged seizures and status epilepticus induce neuronal cell death in the brain. Recent evidence suggests that induction of apoptosis contributes greatly to seizure-induced brain damage. We recently demonstrated that intrahippocampal delivery of botulinum ne...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e32801b3cbb

    authors: Manno I,Antonucci F,Caleo M,Bozzi Y

    更新日期:2007-04-16 00:00:00

  • Enhancement by citral of glutamatergic spontaneous excitatory transmission in adult rat substantia gelatinosa neurons.

    abstract::Although citral, which is abundantly present in lemongrass, has various actions including antinociception, how citral affects synaptic transmission has not been examined as yet. Citral activates in heterologous cells transient receptor potential vanilloid-1, ankyrin-1, and melastatin-8 (TRPV1, TRPA1, and TRPM8, respec...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000000518

    authors: Zhu L,Fujita T,Jiang CY,Kumamoto E

    更新日期:2016-02-10 00:00:00

  • No association between a polymorphism in the presenilin 1 gene and dementia with Lewy bodies.

    abstract::The discovery of mis-sense mutations linking the presenilin-1 (PS-1) gene on chromosome 14 to Alzheimer's disease (AD) has lead to a thorough investigation of this locus. The PS-1 gene contains a polymorphism creating two alleles. The most common allele, allele 1, has been linked with late-onset AD. Given the clinical...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199711100-00042

    authors: Singleton AB,Lamb H,Leake A,McKeith IG,Ince PG,Perry RH,Morris CM

    更新日期:1997-11-10 00:00:00

  • Putamen coactivation during motor task execution.

    abstract::Models of corticostriatal motor circuitry have focused on the role of the circuit in the hemisphere of the motor cortex providing primary control (contralateral to the movement). We used functional magnetic resonance imaging and functional connectivity analyses to study circuit function in both the controlling and non...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e328302c873

    authors: Marchand WR,Lee JN,Thatcher JW,Hsu EW,Rashkin E,Suchy Y,Chelune G,Starr J,Barbera SS

    更新日期:2008-06-11 00:00:00

  • Effects of bromocriptine on human subjects depend on working memory capacity.

    abstract::Pharmacological manipulation of brain dopamine concentration affects visuospatial working memory in humans and in animals, the latter effects localized to the prefrontal cortex. However, the effects of dopamine agonists on humans are poorly understood. We hypothesized that bromocriptine would have an effect on cogniti...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199711100-00032

    authors: Kimberg DY,D'Esposito M,Farah MJ

    更新日期:1997-11-10 00:00:00

  • No relation between 2D : 4D fetal testosterone marker and dyslexia.

    abstract::It has been suggested that high levels of prenatal testosterone exposure are implied in the aetiology of dyslexia and its frequently co-occurring sensory problems. This study examined 2D : 4D digit ratio (a marker of fetal testosterone exposure) in dyslexic and normal reading children. No group differences in 2D : 4D ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e3282e9a754

    authors: Boets B,De Smedt B,Wouters J,Lemay K,Ghesquière P

    更新日期:2007-09-17 00:00:00

  • Reorganization of memory functions after human temporal lobe damage.

    abstract::Hemispheric (re-)organization of episodic memory functions after temporal lobe damage (TLD) was investigated by the intracarotid amobarbital procedure in patients suffering temporal lobe epilepsy. Memory of the speech-dominant left hemisphere was intact after right-sided TLD independent of the age at manifestation. In...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199607080-00020

    authors: Jokeit H,Ebner A,Holthausen H,Markowitsch HJ,Tuxhorn I

    更新日期:1996-07-08 00:00:00