Abstract:
:GABAA receptor-independent effects of benzodiazepine receptor (BZ-R) agonists on calcium and barium spikes were recorded intracellularly in the presence of bicuculline from CA3 hippocampal cells of young and adult rats. Zolpidem (omega 1 BZ-R agonist), had no effects in young animals but decreased calcium and barium spikes and barium currents in adults. Midazolam (omega 1 and omega 2 BZ-R agonist) increased barium spikes in both young and adult animals. The effects on calcium spikes were more complex since a decrease was sometimes preceded by an increase. Thus, in adults zolpidem acting on omega 1 BZ-R reduced calcium influx while in young rats midazolam acting on omega 2 BZ-R increased barium influx. This modulation of calcium spikes by benzodiazepines could be relevant of calcium spikes by benzodiazepines could be relevant because of the developmental role played by calcium dependent processes.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Rovira C,Ben-Ari Ydoi
10.1097/00001756-199410270-00034subject
Has Abstractpub_date
1994-10-27 00:00:00pages
2125-9issue
16eissn
0959-4965issn
1473-558Xjournal_volume
5pub_type
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